Ctsh cathepsin H [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ctshprovided by RGD
Official Full Name: cathepsin Hprovided by RGD
Primary source: RGD:2447
See related: Ensembl:ENSRNOG00000014064 AllianceGenome:RGD:2447
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables aminopeptidase activity; kininogen binding activity; and protein self-association. Involved in several processes, including cellular response to thyroid hormone stimulus; response to odorant; and spermatogenesis. Located in several cellular components, including cytoskeleton; lysosome; and secretory granule. Biomarker of polycystic kidney disease. Orthologous to human CTSH (cathepsin H). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Kidney (RPKM 3767.7), Lung (RPKM 1651.2) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q31

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (99488756..99507639)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (90608941..90627824)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (97439155..97458293)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

cathepsin H is an active participant in lysosome-mediated pre-hormone degradation, and follicular Tg stimulates mobilization of pre-hormones by activating cathepsin H-associated proteolysis pathways
Title: Follicular thyroglobulin induces cathepsin H expression and activity in thyrocytes.
The data provide strong evidence that CTSH is an important regulator of beta-cell function during progression of T1D
Title: CTSH regulates β-cell function and disease progression in newly diagnosed type 1 diabetes patients.
In the amygdala significant up-regulation of interleukin-1 receptor 1 (IL1r1), interleukin-4 receptor (IL4r), fibroblast growth factor 13 (FGF13), and cathepsin-H (CtsH) was observed in males in response to the odor of cornnuts only.
Title: Novel odors affect gene expression for cytokines and proteinases in the rat amygdala and hippocampus.
CTSH overexpression in a subset hepatoma may be thyroid hormone receptor dependent and suggests that this overexpression has an important role in hepatoma progression.
Title: Cathepsin H regulated by the thyroid hormone receptors associate with tumor invasion in human hepatoma cells.
involvement in processing of hydrophobic surfactant-associated protein C in type II pneumocytes
Title: Involvement of cathepsin H in the processing of the hydrophobic surfactant-associated protein C in type II pneumocytes.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables HLA-A specific activating MHC class I receptor activity	IEA Inferred from Electronic Annotation more info
enables HLA-A specific activating MHC class I receptor activity	ISO Inferred from Sequence Orthology more info
enables HLA-A specific activating MHC class I receptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables aminopeptidase activity	IDA Inferred from Direct Assay more info	PubMed
enables aminopeptidase activity	IEA Inferred from Electronic Annotation more info
enables aminopeptidase activity	ISO Inferred from Sequence Orthology more info
enables cysteine-type endopeptidase activator activity involved in apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
enables cysteine-type endopeptidase activator activity involved in apoptotic process	IEA Inferred from Electronic Annotation more info
enables cysteine-type endopeptidase activator activity involved in apoptotic process	ISO Inferred from Sequence Orthology more info
enables cysteine-type endopeptidase activator activity involved in apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
enables cysteine-type endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables cysteine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info
enables cysteine-type endopeptidase activity	ISO Inferred from Sequence Orthology more info
enables cysteine-type endopeptidase activity	ISS Inferred from Sequence or Structural Similarity more info
enables cysteine-type peptidase activity	ISO Inferred from Sequence Orthology more info
enables endopeptidase activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IDA Inferred from Direct Assay more info	PubMed
enables kininogen binding	IPI Inferred from Physical Interaction more info	PubMed
enables peptidase activator activity involved in apoptotic process	ISO Inferred from Sequence Orthology more info
enables peptidase activity	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	IPI Inferred from Physical Interaction more info	PubMed
enables serine-type endopeptidase activity	ISO Inferred from Sequence Orthology more info
enables serine-type endopeptidase activity	ISS Inferred from Sequence or Structural Similarity more info
enables thyroid hormone binding	IEA Inferred from Electronic Annotation more info
enables thyroid hormone binding	ISO Inferred from Sequence Orthology more info
enables thyroid hormone binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in ERK1 and ERK2 cascade	IEA Inferred from Electronic Annotation more info
involved_in ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in ERK1 and ERK2 cascade	ISS Inferred from Sequence or Structural Similarity more info
involved_in T cell mediated cytotoxicity	ISO Inferred from Sequence Orthology more info
involved_in T cell mediated cytotoxicity	ISS Inferred from Sequence or Structural Similarity more info
involved_in adaptive immune response	IEA Inferred from Electronic Annotation more info
involved_in adaptive immune response	ISO Inferred from Sequence Orthology more info
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in bradykinin catabolic process	IEA Inferred from Electronic Annotation more info
involved_in bradykinin catabolic process	ISO Inferred from Sequence Orthology more info
involved_in bradykinin catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to thyroid hormone stimulus	IEA Inferred from Electronic Annotation more info
involved_in cellular response to thyroid hormone stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to thyroid hormone stimulus	ISO Inferred from Sequence Orthology more info
involved_in dichotomous subdivision of terminal units involved in lung branching	ISO Inferred from Sequence Orthology more info
involved_in dichotomous subdivision of terminal units involved in lung branching	ISS Inferred from Sequence or Structural Similarity more info
involved_in immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in immune response-regulating signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in immune response-regulating signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in immune response-regulating signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in membrane protein proteolysis	IEA Inferred from Electronic Annotation more info
involved_in membrane protein proteolysis	ISO Inferred from Sequence Orthology more info
involved_in membrane protein proteolysis	ISS Inferred from Sequence or Structural Similarity more info
involved_in metanephros development	IEP Inferred from Expression Pattern more info	PubMed
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in neuropeptide catabolic process	IEA Inferred from Electronic Annotation more info
involved_in neuropeptide catabolic process	ISO Inferred from Sequence Orthology more info
involved_in neuropeptide catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of angiogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of apoptotic signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell migration	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell migration	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of epithelial cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of epithelial cell migration	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of gene expression	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of peptidase activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein destabilization	IEA Inferred from Electronic Annotation more info
involved_in protein destabilization	ISO Inferred from Sequence Orthology more info
involved_in protein destabilization	ISS Inferred from Sequence or Structural Similarity more info
involved_in proteolysis	ISO Inferred from Sequence Orthology more info
involved_in proteolysis involved in protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to odorant	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to retinoic acid	ISO Inferred from Sequence Orthology more info
involved_in response to retinoic acid	ISS Inferred from Sequence or Structural Similarity more info
involved_in spermatogenesis	IEP Inferred from Expression Pattern more info	PubMed
involved_in surfactant homeostasis	IEA Inferred from Electronic Annotation more info
involved_in surfactant homeostasis	ISO Inferred from Sequence Orthology more info
involved_in surfactant homeostasis	ISS Inferred from Sequence or Structural Similarity more info
involved_in zymogen activation	IEA Inferred from Electronic Annotation more info
involved_in zymogen activation	ISO Inferred from Sequence Orthology more info
involved_in zymogen activation	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in acrosomal vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in alveolar lamellar body	IDA Inferred from Direct Assay more info	PubMed
located_in alveolar lamellar body	IEA Inferred from Electronic Annotation more info
located_in alveolar lamellar body	ISO Inferred from Sequence Orthology more info
located_in alveolar lamellar body	ISS Inferred from Sequence or Structural Similarity more info
located_in axoneme	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasmic ribonucleoprotein granule	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic ribonucleoprotein granule	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	IEA Inferred from Electronic Annotation more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in extracellular space	ISS Inferred from Sequence or Structural Similarity more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
is_active_in lysosome	IBA Inferred from Biological aspect of Ancestor more info
located_in lysosome	IEA Inferred from Electronic Annotation more info
located_in lysosome	ISO Inferred from Sequence Orthology more info
located_in lysosome	ISS Inferred from Sequence or Structural Similarity more info
located_in outer dense fiber	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: pro-cathepsin H

Names: cathepsin B3; cathepsin BA

NP_037071.1

EC 3.4.22.16

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.