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    Dtnb dystrobrevin, beta [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362715, updated on 6-Jun-2024

    Summary

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    Official Symbol
    Dtnbprovided by RGD
    Official Full Name
    dystrobrevin, betaprovided by RGD
    Primary source
    RGD:1309579
    See related
    Ensembl:ENSRNOG00000011914 AllianceGenome:RGD:1309579
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables phosphatase binding activity. Predicted to be involved in neuron differentiation and synaptic signaling. Located in postsynaptic density. Orthologous to human DTNB (dystrobrevin beta). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Thymus (RPKM 117.5), Brain (RPKM 92.7) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Dtnb in Genome Data Viewer
    Location:
    6q14
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (32286022..32483007)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (26566418..26763467)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (27975302..28177236)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene ASXL transcriptional regulator 2 Neighboring gene small ribosomal subunit protein bS21m-like Neighboring gene RNA pseudouridine synthase D4, pseudogene 1 Neighboring gene basic transcription factor 3, pseudogene 5 Neighboring gene DNA methyltransferase 3 alpha Neighboring gene uncharacterized LOC120103494 Neighboring gene Yip1 domain family, member 4 like 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. beta-dystrobrevin, a kinesin-binding receptor, interacts with the extracellular matrix components pancortins. Veroni C, et al. J Neurosci Res, 2007 Sep. PMID 17265465
    2. Beta-dystrobrevin interacts directly with kinesin heavy chain in brain. Macioce P, et al. J Cell Sci, 2003 Dec 1. PMID 14600269
    3. The interaction with HMG20a/b proteins suggests a potential role for beta-dystrobrevin in neuronal differentiation. Artegiani B, et al. J Biol Chem, 2010 Aug 6. PMID 20530487, Free PMC Article
    4. Association of dystrobrevin and regulatory subunit of protein kinase A: a new role for dystrobrevin as a scaffold for signaling proteins. Ceccarini M, et al. J Mol Biol, 2007 Aug 31. PMID 17610895
    5. Dysbindin, a novel coiled-coil-containing protein that interacts with the dystrobrevins in muscle and brain. Benson MA, et al. J Biol Chem, 2001 Jun 29. PMID 11316798

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. beta-dystrobrevin interacts with the HMG20 proteins iBRAF and BRAF35
      Title: The interaction with HMG20a/b proteins suggests a potential role for beta-dystrobrevin in neuronal differentiation.
    2. dystrobrevin is a scaffold protein that may play a role in different cellular processes involving PKA signaling
      Title: Association of dystrobrevin and regulatory subunit of protein kinase A: a new role for dystrobrevin as a scaffold for signaling proteins.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatase binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in neuron differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in synaptic signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in GABA-ergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in basal plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in dendrite IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in inhibitory synapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in inhibitory synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in inhibitory synapse ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in postsynapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in postsynaptic density IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in synapse ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    dystrobrevin beta
    Names
    DTN-B
    beta-dystrobrevin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001393801.1 → NP_001380730.1  dystrobrevin beta

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      A0A8I6AK26
      Related
      ENSRNOP00000095615.1, ENSRNOT00000101006.1
      Conserved Domains (4) summary
      PRK00286
      Location:346 → 526
      xseA; exodeoxyribonuclease VII large subunit; Reviewed
      PRK05431
      Location:440 → 510
      PRK05431; seryl-tRNA synthetase; Provisional
      cd02334
      Location:241 → 288
      ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
      cd16244
      Location:54 → 214
      EFh_DTN; EF-hand-like motif found in dystrobrevins and similar proteins

    RNA

    1. NR_172013.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      32286022..32483007
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063262066.1 → XP_063118136.1  dystrobrevin beta isoform X6

      UniProtKB/TrEMBL
      A0A8I6AK26

    2. XM_063262067.1 → XP_063118137.1  dystrobrevin beta isoform X7

      UniProtKB/TrEMBL
      A0A8I6AE63

    3. XM_063262068.1 → XP_063118138.1  dystrobrevin beta isoform X8

      UniProtKB/TrEMBL
      A0A8I6AE63

    4. XM_039112487.2 → XP_038968415.1  dystrobrevin beta isoform X5

      UniProtKB/Swiss-Prot
      P84060, Q66HF4
      UniProtKB/TrEMBL
      A0A8I6AK26
      Conserved Domains (4) summary
      COG1340
      Location:434 → 515
      COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
      PRK00286
      Location:346 → 526
      xseA; exodeoxyribonuclease VII large subunit; Reviewed
      cd02334
      Location:241 → 288
      ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
      cd16244
      Location:54 → 214
      EFh_DTN; EF-hand-like motif found in dystrobrevins and similar proteins

    5. XM_063262062.1 → XP_063118132.1  dystrobrevin beta isoform X1

      UniProtKB/TrEMBL
      A0A8I6AHC0

    6. XM_063262064.1 → XP_063118134.1  dystrobrevin beta isoform X3

      UniProtKB/TrEMBL
      A0A8L2UMY1

    7. XM_063262063.1 → XP_063118133.1  dystrobrevin beta isoform X2

      UniProtKB/TrEMBL
      A0A8I6AK26

    8. XM_063262065.1 → XP_063118135.1  dystrobrevin beta isoform X4

      UniProtKB/TrEMBL
      A0A8I6AE63

    RNA

    1. XR_010052110.1 RNA Sequence

    2. XR_010052111.1 RNA Sequence

    3. XR_010052112.1 RNA Sequence

    4. XR_010052106.1 RNA Sequence

    5. XR_010052109.1 RNA Sequence

    6. XR_010052107.1 RNA Sequence

    7. XR_010052108.1 RNA Sequence

    8. XR_010052113.1 RNA Sequence

    9. XR_010052114.1 RNA Sequence

    10. XR_010052115.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P84060.2 GenPept UniProtKB/Swiss-Prot:P84060

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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