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    Chchd10 coiled-coil-helix-coiled-coil-helix domain containing 10 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361824, updated on 3-Apr-2024

    Summary

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    Symbol
    Chchd10provided by RGD
    Full Name
    coiled-coil-helix-coiled-coil-helix domain containing 10provided by RGD
    Primary source
    RGD:1359417
    See related
    Ensembl:ENSRNOG00000028356 AllianceGenome:RGD:1359417
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ndg2
    Summary
    Predicted to be involved in several processes, including mitochondria-nucleus signaling pathway; mitochondrial nucleoid organization; and positive regulation of mitochondrion organization. Predicted to be located in mitochondrial intermembrane space. Predicted to be part of MICOS complex. Predicted to be active in mitochondrion and nucleus. Human ortholog(s) of this gene implicated in frontotemporal dementia and/or amyotrophic lateral sclerosis-2. Orthologous to human CHCHD10 (coiled-coil-helix-coiled-coil-helix domain containing 10). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Heart (RPKM 1781.2), Muscle (RPKM 1161.0) and 7 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Chchd10 in Genome Data Viewer
    Location:
    20p12
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (12725274..12730295, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (12725839..12727638, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (13665046..13666845, complement)

    Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 5 member 1 like 1 Neighboring gene similar to human chromosome 22 open reading frame 15 Neighboring gene V-set pre-B cell surrogate light chain 3 Neighboring gene matrix metallopeptidase 11 Neighboring gene SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 Neighboring gene uncharacterized LOC134483889 Neighboring gene derlin 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A mitochondrial origin for frontotemporal dementia and amyotrophic lateral sclerosis through CHCHD10 involvement. Bannwarth S, et al. Brain, 2014 Aug. PMID 24934289, Free PMC Article
    2. Loss of MICOS complex integrity and mitochondrial damage, but not TDP-43 mitochondrial localisation, are likely associated with severity of CHCHD10-related diseases. Genin EC, et al. Neurobiol Dis, 2018 Nov. PMID 30092269, Free PMC Article
    3. CHCHD10 mutations promote loss of mitochondrial cristae junctions with impaired mitochondrial genome maintenance and inhibition of apoptosis. Genin EC, et al. EMBO Mol Med, 2016 Jan 1. PMID 26666268, Free PMC Article
    4. Functional annotation of heart enriched mitochondrial genes GBAS and CHCHD10 through guilt by association. Martherus RS, et al. Biochem Biophys Res Commun, 2010 Nov 12. PMID 20888800
    5. Targeted disruption of the PDZK1 gene in mice causes tissue-specific depletion of the high density lipoprotein receptor scavenger receptor class B type I and altered lipoprotein metabolism. Kocher O, et al. J Biol Chem, 2003 Dec 26. PMID 14551195

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC105647

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in maintenance of protein location in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in maintenance of synapse structure ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitochondria-nucleus signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitochondrial nucleoid organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitochondrion organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrion organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in oxidative phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cristae formation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of mitochondrial transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein-containing complex assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in stabilization of membrane potential ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of MICOS complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial intermembrane space ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    coiled-coil-helix-coiled-coil-helix domain-containing protein 10, mitochondrial
    Names
    Nur77 downstream gene 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001007008.1 → NP_001007009.1  coiled-coil-helix-coiled-coil-helix domain-containing protein 10, mitochondrial

      See identical proteins and their annotated locations for NP_001007009.1

      Status: PROVISIONAL

      Source sequence(s)
      BC082751
      UniProtKB/TrEMBL
      Q63ZY8
      Related
      ENSRNOP00000031008.3, ENSRNOT00000031472.6
      Conserved Domains (1) summary
      pfam06747
      Location:98 → 131
      CHCH; CHCH domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086038.1 Reference GRCr8

      Range
      12725274..12730295 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063279237.1 → XP_063135307.1  coiled-coil-helix-coiled-coil-helix domain-containing protein 10, mitochondrial isoform X1

      UniProtKB/TrEMBL
      Q63ZY8

    2. XM_063279234.1 → XP_063135304.1  coiled-coil-helix-coiled-coil-helix domain-containing protein 10, mitochondrial isoform X1

      UniProtKB/TrEMBL
      Q63ZY8

    3. XM_063279239.1 → XP_063135309.1  coiled-coil-helix-coiled-coil-helix domain-containing protein 10, mitochondrial isoform X1

      UniProtKB/TrEMBL
      Q63ZY8

    4. XM_063279242.1 → XP_063135312.1  coiled-coil-helix-coiled-coil-helix domain-containing protein 10, mitochondrial isoform X1

      UniProtKB/TrEMBL
      Q63ZY8

    5. XM_063279241.1 → XP_063135311.1  coiled-coil-helix-coiled-coil-helix domain-containing protein 10, mitochondrial isoform X1

      UniProtKB/TrEMBL
      Q63ZY8

    6. XM_063279244.1 → XP_063135314.1  coiled-coil-helix-coiled-coil-helix domain-containing protein 10, mitochondrial isoform X1

      UniProtKB/TrEMBL
      Q63ZY8

    7. XM_063279236.1 → XP_063135306.1  coiled-coil-helix-coiled-coil-helix domain-containing protein 10, mitochondrial isoform X1

      UniProtKB/TrEMBL
      Q63ZY8

    8. XM_063279240.1 → XP_063135310.1  coiled-coil-helix-coiled-coil-helix domain-containing protein 10, mitochondrial isoform X1

      UniProtKB/TrEMBL
      Q63ZY8

    9. XM_063279235.1 → XP_063135305.1  coiled-coil-helix-coiled-coil-helix domain-containing protein 10, mitochondrial isoform X1

      UniProtKB/TrEMBL
      Q63ZY8

    10. XM_063279243.1 → XP_063135313.1  coiled-coil-helix-coiled-coil-helix domain-containing protein 10, mitochondrial isoform X1

      UniProtKB/TrEMBL
      Q63ZY8

    11. XM_063279238.1 → XP_063135308.1  coiled-coil-helix-coiled-coil-helix domain-containing protein 10, mitochondrial isoform X1

      UniProtKB/TrEMBL
      Q63ZY8
    Nucleotide Protein Strain
    Heading Accession and Version

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