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    Pcbp2 poly(rC) binding protein 2 [ Mus musculus (house mouse) ]

    Gene ID: 18521, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Pcbp2provided by MGI
    Official Full Name
    poly(rC) binding protein 2provided by MGI
    Primary source
    MGI:MGI:108202
    See related
    Ensembl:ENSMUSG00000056851 AllianceGenome:MGI:108202
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Hnrpx; alphaCP-2
    Summary
    Enables C-rich single-stranded DNA binding activity. Acts upstream of or within positive regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in central nervous system and sensory organ. Orthologous to human PCBP2 (poly(rC) binding protein 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in testis adult (RPKM 95.3), limb E14.5 (RPKM 65.4) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    15 F3; 15 57.61 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (102378974..102408503)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (102470450..102500068)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E1179 Neighboring gene STARR-seq mESC enhancer starr_39843 Neighboring gene predicted gene, 24128 Neighboring gene proline rich 13 Neighboring gene STARR-positive B cell enhancer ABC_E8613 Neighboring gene STARR-seq mESC enhancer starr_39845 Neighboring gene predicted gene, 36331 Neighboring gene mitogen-activated protein kinase kinase kinase 12 Neighboring gene TARBP2, RISC loading complex RNA binding subunit Neighboring gene neuropeptide FF-amide peptide precursor

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Poly C Binding Protein 2 dependent nuclear retention of the utrophin-A mRNA in C2C12 cells. Ghosh G, et al. RNA Biol, 2021 Nov 12. PMID 34904931, Free PMC Article
    2. Novel function of the poly(c)-binding protein α-CP2 as a transcriptional activator that binds to single-stranded DNA sequences. Kang DH, et al. Int J Mol Med, 2013 Nov. PMID 24026233, Free PMC Article
    3. Specific regulation of nucleocytoplasmic distribution of poly(C)-binding protein gene mRNA in mouse development. Hidai C, et al. Biochem Biophys Res Commun, 2003 Sep 19. PMID 12951055
    4. The poly(C)-binding protein Pcbp2 is essential for CD4(+) T cell activation and proliferation. Martinelli M, et al. iScience, 2023 Jan 20. PMID 36632062, Free PMC Article
    5. PCBP2 post-transcriptionally regulates sortilin expression by binding to a C-rich element in its 3' UTR. Yabe-Wada T, et al. FEBS Open Bio, 2020 Mar. PMID 31961070, Free PMC Article

    See all (63) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Poly C Binding Protein 2 dependent nuclear retention of the utrophin-A mRNA in C2C12 cells.
      Title: Poly C Binding Protein 2 dependent nuclear retention of the utrophin-A mRNA in C2C12 cells.
    2. RNA-Binding Proteins PCBP1 and PCBP2 Are Critical Determinants of Murine Erythropoiesis.
      Title: RNA-Binding Proteins PCBP1 and PCBP2 Are Critical Determinants of Murine Erythropoiesis.
    3. PCBP2 post-transcriptionally regulates sortilin expression by binding to a C-rich element in its 3' UTR.
      Title: PCBP2 post-transcriptionally regulates sortilin expression by binding to a C-rich element in its 3' UTR.
    4. Embryos lacking the KH domain poly(C) binding protein, Pcbp2, are selectively deficient in the definitive erythroid lineage. Compared to wild-type controls, transcript splicing analysis of the Pcbp2(-/-) embryonic liver reveals accentuated exclusion of an exon (exon 6) that encodes a highly conserved transcriptional control segment of the hematopoietic master regulator, Runx1.
      Title: Poly(C)-Binding Protein Pcbp2 Enables Differentiation of Definitive Erythropoiesis by Directing Functional Splicing of the Runx1 Transcript.
    5. These findings suggest that Hr mRNA expression is regulated at the post-transcriptional level via IRES-mediated translation control through interaction with PCPB2, but not in MUHH.
      Title: Poly(rC) binding protein 2 acts as a negative regulator of IRES-mediated translation of Hr mRNA.
    6. Study determined that PCBP2 specifically associates with components of this kinase cascade and regulates the activities of its downstream transcriptional coactivators.
      Title: Poly(rC)-Binding Protein 2 Regulates Hippo Signaling To Control Growth in Breast Epithelial Cells.
    7. data suggest that PCBP2 regulates p73 expression via mRNA stability and p73-dependent biological function in ROS production and cellular senescence.
      Title: RNA-binding Protein PCBP2 Regulates p73 Expression and p73-dependent Antioxidant Defense.
    8. PCBP2 overexpression rescues the Meis1 effects of Akt-mTOR pathway and hypertrophy of cardiomyocytes.
      Title: Meis1 promotes poly (rC)-binding protein 2 expression and inhibits angiotensin II-induced cardiomyocyte hypertrophy.
    9. These data reveal that Pcbp1 and Pcbp2 are individually essential for mouse embryonic development and have distinct impacts on embryonic viability and that Pcpb2 has a nonredundant in vivo role in hematopoiesis.
      Title: The Poly(C) Binding Protein Pcbp2 and Its Retrotransposed Derivative Pcbp1 Are Independently Essential to Mouse Development.
    10. PCBP2 knockdown promoted angiotensin II-induced hypertrophy (increase in cell size, protein synthesis and activation of fetal genes) of cardiomyocytes, while PCBP2 overexpression obtained oppose effects.
      Title: The RNA-binding protein PCBP2 inhibits Ang II-induced hypertrophy of cardiomyocytes though promoting GPR56 mRNA degeneration.
    Submit: New GeneRIF Correction See all GeneRIFs (14)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (4)  1 citation
    • Endonuclease-mediated (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC107004

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables C-rich single-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables single-stranded DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables single-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in IRES-dependent viral translational initiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within defense response to virus IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within immune system process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within innate immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of cGAS/STING signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of defense response to virus ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in viral RNA genome replication ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in postsynaptic density ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    poly(rC)-binding protein 2
    Names
    CBP
    CTBP
    alpha-CP2
    heterogeneous nuclear ribonucleoprotein X
    hnRNP X
    putative heterogeneous nuclear ribonucleoprotein X

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001103165.2 → NP_001096635.1  poly(rC)-binding protein 2 isoform 1

      See identical proteins and their annotated locations for NP_001096635.1

      Status: VALIDATED

      Source sequence(s)
      AC137156
      Consensus CDS
      CCDS49741.1
      UniProtKB/Swiss-Prot
      Q61383, Q61990, Q62042
      Related
      ENSMUSP00000076294.6, ENSMUST00000077037.13
      Conserved Domains (3) summary
      cd22515
      Location:13 → 82
      KH-I_PCBP1_2_rpt1; first type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
      cd22518
      Location:92 → 169
      KH-I_PCBP1_2_rpt2; second type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
      cd22521
      Location:281 → 356
      KH-I_PCBP1_2_rpt3; third type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins

    2. NM_001103166.2 → NP_001096636.1  poly(rC)-binding protein 2 isoform 3

      See identical proteins and their annotated locations for NP_001096636.1

      Status: VALIDATED

      Source sequence(s)
      AC137156
      Consensus CDS
      CCDS49742.1
      UniProtKB/Swiss-Prot
      Q61990
      UniProtKB/TrEMBL
      Q3TT81
      Related
      ENSMUSP00000155430.2, ENSMUST00000229618.2
      Conserved Domains (3) summary
      cd22515
      Location:13 → 82
      KH-I_PCBP1_2_rpt1; first type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
      cd22518
      Location:92 → 169
      KH-I_PCBP1_2_rpt2; second type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
      cd22521
      Location:250 → 325
      KH-I_PCBP1_2_rpt3; third type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins

    3. NM_001174073.2 → NP_001167544.1  poly(rC)-binding protein 2 isoform 4

      See identical proteins and their annotated locations for NP_001167544.1

      Status: VALIDATED

      Source sequence(s)
      AC137156
      Consensus CDS
      CCDS88856.1
      UniProtKB/TrEMBL
      Q3TT81
      Related
      ENSMUSP00000104466.5, ENSMUST00000108838.5
      Conserved Domains (3) summary
      cd22515
      Location:13 → 82
      KH-I_PCBP1_2_rpt1; first type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
      cd22518
      Location:92 → 169
      KH-I_PCBP1_2_rpt2; second type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
      cd22521
      Location:241 → 316
      KH-I_PCBP1_2_rpt3; third type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins

    4. NM_001374771.1 → NP_001361700.1  poly(rC)-binding protein 2 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC137156
      Consensus CDS
      CCDS88857.1
      UniProtKB/TrEMBL
      B2M1R7
      Related
      ENSMUSP00000155789.2, ENSMUST00000230114.2
      Conserved Domains (3) summary
      cd22515
      Location:13 → 82
      KH-I_PCBP1_2_rpt1; first type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
      cd22518
      Location:92 → 169
      KH-I_PCBP1_2_rpt2; second type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
      cd22521
      Location:280 → 355
      KH-I_PCBP1_2_rpt3; third type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins

    5. NM_001411538.1 → NP_001398467.1  poly(rC)-binding protein 2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC137156

    6. NM_001411539.1 → NP_001398468.1  poly(rC)-binding protein 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC137156
      UniProtKB/Swiss-Prot
      Q61383, Q61990, Q62042

    7. NM_001411540.1 → NP_001398469.1  poly(rC)-binding protein 2 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC137156

    8. NM_001411541.1 → NP_001398470.1  poly(rC)-binding protein 2 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC137156

    9. NM_001411542.1 → NP_001398471.1  poly(rC)-binding protein 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC137156

    10. NM_001411543.1 → NP_001398472.1  poly(rC)-binding protein 2 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC137156

    11. NM_001411544.1 → NP_001398473.1  poly(rC)-binding protein 2 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC137156

    12. NM_001411545.1 → NP_001398474.1  poly(rC)-binding protein 2 isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC137156

    13. NM_001411546.1 → NP_001398475.1  poly(rC)-binding protein 2 isoform 9

      Status: VALIDATED

      Source sequence(s)
      AC137156

    14. NM_001411547.1 → NP_001398476.1  poly(rC)-binding protein 2 isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC137156

    15. NM_001411548.1 → NP_001398477.1  poly(rC)-binding protein 2 isoform 9

      Status: VALIDATED

      Source sequence(s)
      AC137156

    16. NM_001411549.1 → NP_001398478.1  poly(rC)-binding protein 2 isoform 10

      Status: VALIDATED

      Source sequence(s)
      AC137156
      UniProtKB/TrEMBL
      B2M1R7

    17. NM_001411550.1 → NP_001398479.1  poly(rC)-binding protein 2 isoform 11

      Status: VALIDATED

      Source sequence(s)
      AC137156

    18. NM_001411551.1 → NP_001398480.1  poly(rC)-binding protein 2 isoform 11

      Status: VALIDATED

      Source sequence(s)
      AC137156

    19. NM_001411552.1 → NP_001398481.1  poly(rC)-binding protein 2 isoform 12

      Status: VALIDATED

      Source sequence(s)
      AC137156

    20. NM_001411553.1 → NP_001398482.1  poly(rC)-binding protein 2 isoform 12

      Status: VALIDATED

      Source sequence(s)
      AC137156

    21. NM_001411554.1 → NP_001398483.1  poly(rC)-binding protein 2 isoform 13

      Status: VALIDATED

      Source sequence(s)
      AC137156

    22. NM_001411555.1 → NP_001398484.1  poly(rC)-binding protein 2 isoform 14

      Status: VALIDATED

      Source sequence(s)
      AC137156

    23. NM_001411556.1 → NP_001398485.1  poly(rC)-binding protein 2 isoform 15

      Status: VALIDATED

      Source sequence(s)
      AC137156

    24. NM_001411557.1 → NP_001398486.1  poly(rC)-binding protein 2 isoform 13

      Status: VALIDATED

      Source sequence(s)
      AC137156

    25. NM_001411558.1 → NP_001398487.1  poly(rC)-binding protein 2 isoform 16

      Status: VALIDATED

      Source sequence(s)
      AC137156

    26. NM_001411559.1 → NP_001398488.1  poly(rC)-binding protein 2 isoform 14

      Status: VALIDATED

      Source sequence(s)
      AC137156

    27. NM_011042.3 → NP_035172.2  poly(rC)-binding protein 2 isoform 2

      See identical proteins and their annotated locations for NP_035172.2

      Status: VALIDATED

      Source sequence(s)
      AC137156
      Consensus CDS
      CCDS27884.1
      UniProtKB/Swiss-Prot
      Q61990
      UniProtKB/TrEMBL
      Q3TT81
      Related
      ENSMUSP00000155038.2, ENSMUST00000229854.2
      Conserved Domains (3) summary
      cd22515
      Location:13 → 82
      KH-I_PCBP1_2_rpt1; first type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
      cd22518
      Location:92 → 169
      KH-I_PCBP1_2_rpt2; second type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
      cd22521
      Location:268 → 343
      KH-I_PCBP1_2_rpt3; third type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      102378974..102408503
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030248387.1 → XP_030104247.1  poly(rC)-binding protein 2 isoform X7

      Conserved Domains (2) summary
      cd02396
      Location:99 → 163
      PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...
      pfam00013
      Location:274 → 336
      KH_1; KH domain

    2. XM_006520582.4 → XP_006520645.1  poly(rC)-binding protein 2 isoform X16

      See identical proteins and their annotated locations for XP_006520645.1

      Conserved Domains (3) summary
      cd22515
      Location:13 → 82
      KH-I_PCBP1_2_rpt1; first type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
      cd22518
      Location:92 → 169
      KH-I_PCBP1_2_rpt2; second type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
      cd22521
      Location:285 → 360
      KH-I_PCBP1_2_rpt3; third type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins

    3. XM_017316497.2 → XP_017171986.1  poly(rC)-binding protein 2 isoform X17

      Conserved Domains (3) summary
      cd22515
      Location:13 → 82
      KH-I_PCBP1_2_rpt1; first type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
      cd22518
      Location:92 → 169
      KH-I_PCBP1_2_rpt2; second type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
      cd22521
      Location:284 → 359
      KH-I_PCBP1_2_rpt3; third type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins

    4. XM_006520583.4 → XP_006520646.1  poly(rC)-binding protein 2 isoform X20

      See identical proteins and their annotated locations for XP_006520646.1

      Conserved Domains (3) summary
      cd22515
      Location:13 → 82
      KH-I_PCBP1_2_rpt1; first type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
      cd22518
      Location:92 → 169
      KH-I_PCBP1_2_rpt2; second type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
      cd22521
      Location:272 → 347
      KH-I_PCBP1_2_rpt3; third type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins

    5. XM_017316499.2 → XP_017171988.1  poly(rC)-binding protein 2 isoform X21

      Conserved Domains (3) summary
      cd22515
      Location:13 → 82
      KH-I_PCBP1_2_rpt1; first type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
      cd22518
      Location:92 → 169
      KH-I_PCBP1_2_rpt2; second type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
      cd22521
      Location:271 → 346
      KH-I_PCBP1_2_rpt3; third type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins

    6. XM_006520584.4 → XP_006520647.1  poly(rC)-binding protein 2 isoform X24

      See identical proteins and their annotated locations for XP_006520647.1

      UniProtKB/TrEMBL
      A0A2R8VHP9
      Related
      ENSMUSP00000155292.2, ENSMUST00000229802.2
      Conserved Domains (3) summary
      cd22515
      Location:13 → 82
      KH-I_PCBP1_2_rpt1; first type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
      cd22518
      Location:92 → 169
      KH-I_PCBP1_2_rpt2; second type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
      cd22521
      Location:254 → 329
      KH-I_PCBP1_2_rpt3; third type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins

    7. XM_030248401.1 → XP_030104261.1  poly(rC)-binding protein 2 isoform X25

      Related
      ENSMUSP00000155654.2, ENSMUST00000229184.2
      Conserved Domains (3) summary
      cd22515
      Location:13 → 82
      KH-I_PCBP1_2_rpt1; first type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
      cd22518
      Location:92 → 169
      KH-I_PCBP1_2_rpt2; second type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
      cd22521
      Location:253 → 328
      KH-I_PCBP1_2_rpt3; third type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins

    8. XM_006520585.4 → XP_006520648.1  poly(rC)-binding protein 2 isoform X28

      See identical proteins and their annotated locations for XP_006520648.1

      UniProtKB/TrEMBL
      Q3TT81
      Conserved Domains (3) summary
      cd22515
      Location:13 → 82
      KH-I_PCBP1_2_rpt1; first type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
      cd22518
      Location:92 → 169
      KH-I_PCBP1_2_rpt2; second type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
      cd22521
      Location:241 → 316
      KH-I_PCBP1_2_rpt3; third type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins

    9. XM_017316501.2 → XP_017171990.1  poly(rC)-binding protein 2 isoform X29

      Conserved Domains (3) summary
      cd22515
      Location:13 → 82
      KH-I_PCBP1_2_rpt1; first type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
      cd22518
      Location:92 → 169
      KH-I_PCBP1_2_rpt2; second type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
      cd22521
      Location:240 → 315
      KH-I_PCBP1_2_rpt3; third type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins

    10. XM_011245495.3 → XP_011243797.1  poly(rC)-binding protein 2 isoform X1

      See identical proteins and their annotated locations for XP_011243797.1

      Conserved Domains (3) summary
      cd22515
      Location:13 → 82
      KH-I_PCBP1_2_rpt1; first type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
      cd22518
      Location:92 → 169
      KH-I_PCBP1_2_rpt2; second type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
      cd22521
      Location:285 → 360
      KH-I_PCBP1_2_rpt3; third type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins

    11. XM_011245497.3 → XP_011243799.1  poly(rC)-binding protein 2 isoform X2

      Conserved Domains (3) summary
      cd22515
      Location:13 → 82
      KH-I_PCBP1_2_rpt1; first type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
      cd22518
      Location:92 → 169
      KH-I_PCBP1_2_rpt2; second type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
      cd22521
      Location:284 → 359
      KH-I_PCBP1_2_rpt3; third type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins

    12. XM_011245501.3 → XP_011243803.1  poly(rC)-binding protein 2 isoform X5

      See identical proteins and their annotated locations for XP_011243803.1

      Conserved Domains (3) summary
      cd22515
      Location:13 → 82
      KH-I_PCBP1_2_rpt1; first type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
      cd22518
      Location:92 → 169
      KH-I_PCBP1_2_rpt2; second type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
      cd22521
      Location:272 → 347
      KH-I_PCBP1_2_rpt3; third type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins

    13. XM_011245502.3 → XP_011243804.1  poly(rC)-binding protein 2 isoform X6

      Conserved Domains (3) summary
      cd22515
      Location:13 → 82
      KH-I_PCBP1_2_rpt1; first type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
      cd22518
      Location:92 → 169
      KH-I_PCBP1_2_rpt2; second type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
      cd22521
      Location:271 → 346
      KH-I_PCBP1_2_rpt3; third type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins

    14. XM_011245503.3 → XP_011243805.1  poly(rC)-binding protein 2 isoform X9

      See identical proteins and their annotated locations for XP_011243805.1

      Conserved Domains (3) summary
      cd22515
      Location:13 → 82
      KH-I_PCBP1_2_rpt1; first type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
      cd22518
      Location:92 → 169
      KH-I_PCBP1_2_rpt2; second type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
      cd22521
      Location:254 → 329
      KH-I_PCBP1_2_rpt3; third type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins

    15. XM_030248391.1 → XP_030104251.1  poly(rC)-binding protein 2 isoform X10

      Conserved Domains (2) summary
      cd02396
      Location:99 → 163
      PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...
      pfam00013
      Location:259 → 321
      KH_1; KH domain

    16. XM_030248392.1 → XP_030104252.1  poly(rC)-binding protein 2 isoform X13

      Conserved Domains (3) summary
      cd22515
      Location:13 → 82
      KH-I_PCBP1_2_rpt1; first type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
      cd22518
      Location:92 → 169
      KH-I_PCBP1_2_rpt2; second type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
      cd22521
      Location:241 → 316
      KH-I_PCBP1_2_rpt3; third type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins

    17. XM_030248389.1 → XP_030104249.1  poly(rC)-binding protein 2 isoform X8

      Conserved Domains (2) summary
      cd02396
      Location:99 → 163
      PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...
      pfam00013
      Location:273 → 335
      KH_1; KH domain

    18. XM_030248394.1 → XP_030104254.1  poly(rC)-binding protein 2 isoform X15

      Conserved Domains (2) summary
      cd02396
      Location:99 → 163
      PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...
      pfam00013
      Location:242 → 304
      KH_1; KH domain

    19. XM_011245496.2 → XP_011243798.1  poly(rC)-binding protein 2 isoform X1

      See identical proteins and their annotated locations for XP_011243798.1

      Conserved Domains (3) summary
      cd22515
      Location:13 → 82
      KH-I_PCBP1_2_rpt1; first type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
      cd22518
      Location:92 → 169
      KH-I_PCBP1_2_rpt2; second type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
      cd22521
      Location:285 → 360
      KH-I_PCBP1_2_rpt3; third type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins

    20. XM_030248390.1 → XP_030104250.1  poly(rC)-binding protein 2 isoform X8

      Conserved Domains (2) summary
      cd02396
      Location:99 → 163
      PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...
      pfam00013
      Location:273 → 335
      KH_1; KH domain

    21. XM_030248393.1 → XP_030104253.1  poly(rC)-binding protein 2 isoform X14

      Conserved Domains (2) summary
      cd02396
      Location:99 → 163
      PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...
      pfam00013
      Location:243 → 305
      KH_1; KH domain

    22. XM_011245509.2 → XP_011243811.1  poly(rC)-binding protein 2 isoform X15

      Conserved Domains (2) summary
      cd02396
      Location:99 → 163
      PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...
      pfam00013
      Location:242 → 304
      KH_1; KH domain

    23. XM_030248396.1 → XP_030104256.1  poly(rC)-binding protein 2 isoform X18

      UniProtKB/Swiss-Prot
      Q61383, Q61990, Q62042
      Conserved Domains (3) summary
      cd22515
      Location:13 → 82
      KH-I_PCBP1_2_rpt1; first type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
      cd22518
      Location:92 → 169
      KH-I_PCBP1_2_rpt2; second type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
      cd22521
      Location:281 → 356
      KH-I_PCBP1_2_rpt3; third type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q61990.1 GenPept UniProtKB/Swiss-Prot:Q61990

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