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    Cyp2j6 cytochrome P450, family 2, subfamily j, polypeptide 6 [ Mus musculus (house mouse) ]

    Gene ID: 13110, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Cyp2j6provided by MGI
    Official Full Name
    cytochrome P450, family 2, subfamily j, polypeptide 6provided by MGI
    Primary source
    MGI:MGI:1270148
    See related
    Ensembl:ENSMUSG00000052914 AllianceGenome:MGI:1270148
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Enables arachidonic acid epoxygenase activity. Predicted to be involved in several processes, including negative regulation of collagen biosynthetic process; negative regulation of peroxisome proliferator activated receptor signaling pathway; and unsaturated fatty acid metabolic process. Located in endoplasmic reticulum. Is expressed in several structures, including alimentary system; integumental system; metanephros; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in hypertension (multiple); myocardial infarction; and renal fibrosis. Orthologous to human CYP2J2 (cytochrome P450 family 2 subfamily J member 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in duodenum adult (RPKM 4.6), large intestine adult (RPKM 2.5) and 22 other tissues See more
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    Genomic context

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    See Cyp2j6 in Genome Data Viewer
    Location:
    4 C5; 4 44.62 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (96404375..96449835, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (96516138..96564305, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene cytochrome P450, family 2, subfamily j, member 14, pseudogene Neighboring gene STARR-seq mESC enhancer starr_10825 Neighboring gene cytochrome P450, family 2, subfamily j, polypeptide 8 Neighboring gene STARR-seq mESC enhancer starr_10826 Neighboring gene cytochrome P450, family 2, subfamily j, polypeptide 9 Neighboring gene cytochrome P450, family 2, subfamily j, polypeptide 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Molecular cloning and characterization of mouse CYP2J6, an unstable cytochrome P450 isoform. Ma J, et al. Biochem Pharmacol, 2002 Nov 15. PMID 12417258
    2. Targeting CYP2J to reduce paclitaxel-induced peripheral neuropathic pain. Sisignano M, et al. Proc Natl Acad Sci U S A, 2016 Nov 1. PMID 27791151, Free PMC Article
    3. Molecular cloning, enzymatic characterization, developmental expression, and cellular localization of a mouse cytochrome P450 highly expressed in kidney. Ma J, et al. J Biol Chem, 1999 Jun 18. PMID 10364221
    4. Enhanced postischemic functional recovery in CYP2J2 transgenic hearts involves mitochondrial ATP-sensitive K+ channels and p42/p44 MAPK pathway. Seubert J, et al. Circ Res, 2004 Sep 3. PMID 15256482
    5. Modulation by salt intake of the vascular response mediated through adenosine A(2A) receptor: role of CYP epoxygenase and soluble epoxide hydrolase. Nayeem MA, et al. Am J Physiol Regul Integr Comp Physiol, 2010 Jul. PMID 20427718, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables NADPH-hemoprotein reductase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables arachidonic acid 11,12-epoxygenase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables arachidonic acid 14,15-epoxygenase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables arachidonic acid epoxygenase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables arachidonic acid epoxygenase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables arachidonic acid monooxygenase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables aromatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables heme binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables isomerase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables linoleic acid epoxygenase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables monooxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in arachidonic acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in epoxygenase P450 pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in icosanoid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in linoleic acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of collagen biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of peroxisome proliferator activated receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in organic acid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of extracellular matrix organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of gluconeogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of tumor necrosis factor production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in retinoid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in xenobiotic metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    cytochrome P450 2J6
    Names
    CYPIIJ6
    arachidonic acid epoxygenase
    cytochrome P450, 2j6
    NP_001407757.1
    NP_034138.3
    XP_006502785.1
    XP_030109023.1
    XP_036019523.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001420828.1 → NP_001407757.1  cytochrome P450 2J6 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL683816

    2. NM_010008.5 → NP_034138.3  cytochrome P450 2J6 isoform 1

      See identical proteins and their annotated locations for NP_034138.3

      Status: VALIDATED

      Source sequence(s)
      AL683816
      Consensus CDS
      CCDS18369.1
      UniProtKB/Swiss-Prot
      O54750, Q8BR78
      UniProtKB/TrEMBL
      Q8CC91
      Related
      ENSMUSP00000030303.5, ENSMUST00000030303.6
      Conserved Domains (1) summary
      pfam00067
      Location:44 → 496
      p450; Cytochrome P450

    RNA

    1. NR_185201.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL683816

    2. NR_185202.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL683816

    3. NR_185203.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL683816

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      96404375..96449835 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006502722.5 → XP_006502785.1  cytochrome P450 2J6 isoform X4

      Conserved Domains (1) summary
      cl41757
      Location:1 → 259
      cytochrome_P450; cytochrome P450 (CYP) superfamily

    2. XM_036163630.1 → XP_036019523.1  cytochrome P450 2J6 isoform X4

      Conserved Domains (1) summary
      cl41757
      Location:1 → 259
      cytochrome_P450; cytochrome P450 (CYP) superfamily

    3. XM_030253163.2 → XP_030109023.1  cytochrome P450 2J6 isoform X5

      Conserved Domains (1) summary
      cl12078
      Location:44 → 229
      p450; Cytochrome P450
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O54750.2 GenPept UniProtKB/Swiss-Prot:O54750

    Gene LinkOut

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