DGKZ diacylglycerol kinase zeta [Homo sapiens (human)] - Gene

Summary

Official Symbol: DGKZprovided by HGNC
Official Full Name: diacylglycerol kinase zetaprovided by HGNC
Primary source: HGNC:HGNC:2857
See related: Ensembl:ENSG00000149091 MIM:601441; AllianceGenome:HGNC:2857
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: DAGK5; DAGK6; DGK-ZETA; hDGKzeta
Summary: The protein encoded by this gene belongs to the eukaryotic diacylglycerol kinase family. It may attenuate protein kinase C activity by regulating diacylglycerol levels in intracellular signaling cascade and signal transduction. Alternative splicing occurs at this locus and multiple transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Nov 2010]
Expression: Ubiquitous expression in brain (RPKM 24.7), bone marrow (RPKM 15.6) and 24 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 11p11.2

Exon count:: 35

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	11	NC_000011.10 (46332926..46380554)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	11	NC_060935.1 (46489001..46536630)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	11	NC_000011.9 (46354476..46402104)

Chromosome 11 - NC_000011.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Exome Sequencing Implicates DGKZ , ESRRA , and GXYLT1 for Modulating Granuloma Formation in Crohn Disease.
Title: Exome Sequencing Implicates DGKZ , ESRRA , and GXYLT1 for Modulating Granuloma Formation in Crohn Disease.
Differential expression of diacylglycerol kinase zeta is involved in inferior parietal lobule-related dysfunction in schizophrenia with cognitive impairments.
Title: Differential expression of diacylglycerol kinase ζ is involved in inferior parietal lobule-related dysfunction in schizophrenia with cognitive impairments.
Diacylglycerol kinase zeta interacts with sphingomyelin synthase 1 and sphingomyelin synthase-related protein via different regions.
Title: Diacylglycerol kinase ζ interacts with sphingomyelin synthase 1 and sphingomyelin synthase-related protein via different regions.
Identification and characterization of diacylglycerol kinase zeta as a novel enzyme producing ceramide-1-phosphate.
Title: Identification and characterization of diacylglycerol kinase ζ as a novel enzyme producing ceramide-1-phosphate.
DGKZ promotes TGFbeta signaling pathway and metastasis in triple-negative breast cancer by suppressing lipid raft-dependent endocytosis of TGFbetaR2.
Title: DGKZ promotes TGFβ signaling pathway and metastasis in triple-negative breast cancer by suppressing lipid raft-dependent endocytosis of TGFβR2.
Downregulation of Diacylglycerol kinase zeta (DGKZ) suppresses tumorigenesis and progression of cervical cancer by facilitating cell apoptosis and cell cycle arrest.
Title: Downregulation of Diacylglycerol kinase zeta (DGKZ) suppresses tumorigenesis and progression of cervical cancer by facilitating cell apoptosis and cell cycle arrest.
Diacylglycerol kinase zeta limits IL-2-dependent control of PD-1 expression in tumor-infiltrating T lymphocytes.
Title: Diacylglycerol kinase ζ limits IL-2-dependent control of PD-1 expression in tumor-infiltrating T lymphocytes.
DGKzeta depletion attenuates HIF-1alpha induction and SIRT1 expression, but enhances TAK1-mediated AMPKalpha phosphorylation under hypoxia.
Title: DGKζ depletion attenuates HIF-1α induction and SIRT1 expression, but enhances TAK1-mediated AMPKα phosphorylation under hypoxia.
Regulation of p53 and NF-kappaB transactivation activities by DGKzeta in catalytic activity-dependent and -independent manners.
Title: Regulation of p53 and NF-κB transactivation activities by DGKζ in catalytic activity-dependent and -independent manners.
Characterization of alpha-synuclein N-terminal domain as a novel cellular phosphatidic acid sensor.
Title: Characterization of α-synuclein N-terminal domain as a novel cellular phosphatidic acid sensor.

Submit: New GeneRIF Correction See all GeneRIFs (37)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Association of IFIH1 and other autoimmunity risk alleles with selective IgA deficiency. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

PMC20810P1 (e-PCR)
- UniSTS:271977

PMC20810P2 (e-PCR)
- UniSTS:271978

RH48086 (e-PCR)
- UniSTS:88700

DGKZ_1591 (e-PCR)
- UniSTS:277163

MARC_9821-9822:996688622:1 (e-PCR)
- UniSTS:270005

RH12588 (e-PCR)
- UniSTS:2807

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP-dependent diacylglycerol kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ATP-dependent diacylglycerol kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables ATP-dependent diacylglycerol kinase activity	TAS Traceable Author Statement more info
enables alkylglycerol kinase activity	IEA Inferred from Electronic Annotation more info
enables kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cell migration	NAS Non-traceable Author Statement more info	PubMed
involved_in diacylglycerol metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in diacylglycerol metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in glycerolipid metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in lipid phosphorylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in lipid phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of T cell receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in phosphatidic acid biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in phosphatidic acid biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in phosphatidic acid biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in phosphatidic acid biosynthetic process	TAS Traceable Author Statement more info	PubMed
involved_in platelet activation	TAS Traceable Author Statement more info
involved_in protein kinase C-activating G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	TAS Traceable Author Statement more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IBA Inferred from Biological aspect of Ancestor more info
located_in lamellipodium	IDA Inferred from Direct Assay more info	PubMed
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in nuclear speck	IDA Inferred from Direct Assay more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: diacylglycerol kinase zeta

Names: DAG kinase zeta; diacylglycerol kinase, zeta 104kDa; diglyceride kinase zeta

NP_001099010.1

EC 2.7.1.107

EC 2.7.1.93

NP_001186195.1

EC 2.7.1.107

EC 2.7.1.93

NP_001186196.1

EC 2.7.1.107

EC 2.7.1.93

NP_001186197.1

EC 2.7.1.107

EC 2.7.1.93

NP_003637.2

EC 2.7.1.107

EC 2.7.1.93

NP_963290.1

EC 2.7.1.107

EC 2.7.1.93

NP_963291.2

EC 2.7.1.107

EC 2.7.1.93

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_047092.1 RefSeqGene

Range

19559..52647

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001105540.2 → NP_001099010.1 diacylglycerol kinase zeta isoform 4

See identical proteins and their annotated locations for NP_001099010.1

Status: REVIEWED

Description

Transcript Variant: This variant (4) encodes the longest isoform (4).

Source sequence(s)

AC116021, U94905

Consensus CDS

CCDS41640.1

UniProtKB/TrEMBL

Q6ZT25

Related

ENSP00000412178.1, ENST00000454345.6

Conserved Domains (7) summary

smart00045
Location:635 → 792

DAGKa; Diacylglycerol kinase accessory domain (presumed)

smart00046
Location:486 → 607

DAGKc; Diacylglycerol kinase catalytic domain (presumed)

COG1597
Location:482 → 805

LCB5; Diacylglycerol kinase family enzyme [Lipid transport and metabolism, General function prediction only]

cd00204
Location:983 → 1099

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam00130
Location:361 → 420

C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

pfam12796
Location:983 → 1077

Ank_2; Ankyrin repeats (3 copies)

sd00045
Location:983 → 1009

ANK; ANK repeat [structural motif]
NM_001199266.2 → NP_001186195.1 diacylglycerol kinase zeta isoform 5

Status: REVIEWED

Description

Transcript Variant: This variant (5) has an alternate 5' sequence including the coding region and extra nts CAG and an extra segment at alternate splice sites, respectively, in the CDS, compared to variant 4. The resulting isoform (5) has a shorter and distinct N-terminus, and an internal additional aa and an additional segment, compared to isoform 4.

Source sequence(s)

AK225774, CB959911, U51477

Consensus CDS

CCDS55757.1

UniProtKB/TrEMBL

Q6ZT25

Related

ENSP00000436291.1, ENST00000527911.5

Conserved Domains (7) summary

smart00045
Location:447 → 604

DAGKa; Diacylglycerol kinase accessory domain (presumed)

smart00046
Location:298 → 419

DAGKc; Diacylglycerol kinase catalytic domain (presumed)

COG1597
Location:294 → 617

LCB5; Diacylglycerol kinase family enzyme [Lipid transport and metabolism, General function prediction only]

cd00204
Location:795 → 916

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam12796
Location:795 → 894

Ank_2; Ankyrin repeats (3 copies)

sd00045
Location:795 → 821

ANK; ANK repeat [structural motif]

cl00040
Location:173 → 232

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
NM_001199267.2 → NP_001186196.1 diacylglycerol kinase zeta isoform 6

See identical proteins and their annotated locations for NP_001186196.1

Status: REVIEWED

Description

Transcript Variant: This variant (6) has an alternate 5' sequence including the coding region compared to variant 4. The resulting isoform (6) has a shorter and distinct N-terminus, compared to isoform 4.

Source sequence(s)

CB959911, U51477

Consensus CDS

CCDS55759.1

UniProtKB/Swiss-Prot

B7Z2M9, B7Z6M3, E9PPW4, F6UCU9, G3V0F6, J3KNJ6, O00542, Q13574, Q6ZVG7, Q8IVW9

UniProtKB/TrEMBL

Q6ZT25

Related

ENSP00000395684.2, ENST00000456247.7

Conserved Domains (6) summary

smart00045
Location:446 → 603

DAGKa; Diacylglycerol kinase accessory domain (presumed)

smart00046
Location:297 → 418

DAGKc; Diacylglycerol kinase catalytic domain (presumed)

sd00045
Location:794 → 820

ANK; ANK repeat [structural motif]

pfam12796
Location:794 → 888

Ank_2; Ankyrin repeats (3 copies)

cd20849
Location:88 → 160

C1_DGKzeta_rpt1; first protein kinase C conserved region 1 (C1 domain) found in diacylglycerol kinase zeta (DAG kinase zeta) and similar proteins

cd20895
Location:170 → 244

C1_DGKzeta_rpt2; second protein kinase C conserved region 1 (C1 domain) found in diacylglycerol kinase zeta (DAG kinase zeta) and similar proteins
NM_001199268.2 → NP_001186197.1 diacylglycerol kinase zeta isoform 7

Status: REVIEWED

Description

Transcript Variant: This variant (7) has an alternate 5' sequence including the coding region and extra nts CAG at an alternate splice site in the CDS, and lacks an in-frame coding exon, compared to variant 4. The resulting isoform (7) has a shorter and distinct N-terminus and an internal additional aa, and lacks an internal segment, compared to isoform 4.

Source sequence(s)

AK294888, CB959911, U51477

Consensus CDS

CCDS55758.1

UniProtKB/TrEMBL

Q6ZT25

Related

ENSP00000320340.8, ENST00000318201.12

Conserved Domains (6) summary

smart00045
Location:424 → 581

DAGKa; Diacylglycerol kinase accessory domain (presumed)

smart00046
Location:275 → 396

DAGKc; Diacylglycerol kinase catalytic domain (presumed)

COG1597
Location:271 → 594

LCB5; Diacylglycerol kinase family enzyme [Lipid transport and metabolism, General function prediction only]

cd00204
Location:772 → 888

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam12796
Location:772 → 866

Ank_2; Ankyrin repeats (3 copies)

sd00045
Location:772 → 798

ANK; ANK repeat [structural motif]
NM_003646.4 → NP_003637.2 diacylglycerol kinase zeta isoform 2

See identical proteins and their annotated locations for NP_003637.2

Status: REVIEWED

Description

Transcript Variant: This variant (2) has an alternate 5' sequence including the coding region and extra nts CAG at an alternate splice site in the CDS, compared to variant 4. The resulting isoform (2) has a shorter and distinct N-terminus and an internal additional aa, compared to isoform 4.

Source sequence(s)

BU849628, CB959911, U94905

Consensus CDS

CCDS44580.1

UniProtKB/TrEMBL

Q6ZT25

Related

ENSP00000391021.2, ENST00000421244.6

Conserved Domains (6) summary

smart00045
Location:447 → 604

DAGKa; Diacylglycerol kinase accessory domain (presumed)

smart00046
Location:298 → 419

DAGKc; Diacylglycerol kinase catalytic domain (presumed)

sd00045
Location:795 → 821

ANK; ANK repeat [structural motif]

pfam12796
Location:795 → 889

Ank_2; Ankyrin repeats (3 copies)

cd20849
Location:88 → 161

C1_DGKzeta_rpt1; first protein kinase C conserved region 1 (C1 domain) found in diacylglycerol kinase zeta (DAG kinase zeta) and similar proteins

cd20895
Location:171 → 245

C1_DGKzeta_rpt2; second protein kinase C conserved region 1 (C1 domain) found in diacylglycerol kinase zeta (DAG kinase zeta) and similar proteins
NM_201532.3 → NP_963290.1 diacylglycerol kinase zeta isoform 1

See identical proteins and their annotated locations for NP_963290.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) has an alternate 5' sequence including the coding region, compared to variant 4. The resulting isoform (1) has a shorter and distinct N-terminus, compared to isoform 4.

Source sequence(s)

AK124594

Consensus CDS

CCDS7918.1

UniProtKB/TrEMBL

Q6ZT25

Related

ENSP00000343065.6, ENST00000343674.10

Conserved Domains (7) summary

smart00045
Location:463 → 620

DAGKa; Diacylglycerol kinase accessory domain (presumed)

smart00046
Location:314 → 435

DAGKc; Diacylglycerol kinase catalytic domain (presumed)

COG1597
Location:310 → 633

LCB5; Diacylglycerol kinase family enzyme [Lipid transport and metabolism, General function prediction only]

cd00204
Location:811 → 927

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam12796
Location:811 → 905

Ank_2; Ankyrin repeats (3 copies)

sd00045
Location:811 → 837

ANK; ANK repeat [structural motif]

cl00040
Location:189 → 248

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
NM_201533.3 → NP_963291.2 diacylglycerol kinase zeta isoform 3

Status: REVIEWED

Description

Transcript Variant: This variant (3) has an alternate 5' sequence including the coding region, lacks nts GAG at an alternate splice site and has extra nts CAG at another alternate splice sites in the CDS, compared to variant 4. The resulting isoform (3) has a shorter and distinct N-terminus, lacks an internal aa in one region and has an additional aa in another region, compared to isoform 4.

Source sequence(s)

AK300577, DC416889, U51477

Consensus CDS

CCDS44579.2

UniProtKB/TrEMBL

Q6ZT25

Related

ENSP00000436273.2, ENST00000532868.6

Conserved Domains (7) summary

smart00045
Location:451 → 608

DAGKa; Diacylglycerol kinase accessory domain (presumed)

smart00046
Location:302 → 423

DAGKc; Diacylglycerol kinase catalytic domain (presumed)

COG1597
Location:298 → 621

LCB5; Diacylglycerol kinase family enzyme [Lipid transport and metabolism, General function prediction only]

cd00204
Location:799 → 915

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam12796
Location:799 → 893

Ank_2; Ankyrin repeats (3 copies)

sd00045
Location:799 → 825

ANK; ANK repeat [structural motif]

cl00040
Location:177 → 236

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...