ELK4 ETS transcription factor ELK4 [Homo sapiens (human)] - Gene

Summary

Official Symbol: ELK4provided by HGNC
Official Full Name: ETS transcription factor ELK4provided by HGNC
Primary source: HGNC:HGNC:3326
See related: Ensembl:ENSG00000158711 MIM:600246; AllianceGenome:HGNC:3326
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: SAP1
Summary: This gene is a member of the Ets family of transcription factors and of the ternary complex factor (TCF) subfamily. Proteins of the TCF subfamily form a ternary complex by binding to the the serum response factor and the serum reponse element in the promoter of the c-fos proto-oncogene. The protein encoded by this gene is phosphorylated by the kinases, MAPK1 and MAPK8. Several transcript variants have been described for this gene. [provided by RefSeq, Jul 2008]
Expression: Ubiquitous expression in prostate (RPKM 12.4), lymph node (RPKM 7.6) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 1q32.1

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	1	NC_000001.11 (205607943..205632011, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	1	NC_060925.1 (204872578..204896650, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	1	NC_000001.10 (205577071..205601139, complement)

Chromosome 1 - NC_000001.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ELK4 Promotes Cell Cycle Progression and Stem Cell-like Characteristics in HPV-associated Cervical Cancer by Regulating the FBXO22/PTEN Axis.
Title: ELK4 Promotes Cell Cycle Progression and Stem Cell-like Characteristics in HPV-associated Cervical Cancer by Regulating the FBXO22/PTEN Axis.
IGF1R-phosphorylated PYCR1 facilitates ELK4 transcriptional activity and sustains tumor growth under hypoxia.
Title: IGF1R-phosphorylated PYCR1 facilitates ELK4 transcriptional activity and sustains tumor growth under hypoxia.
ELK4-mediated lncRNA SNHG22 promotes gastric cancer progression through interacting with EZH2 and regulating miR-200c-3p/Notch1 axis.
Title: ELK4-mediated lncRNA SNHG22 promotes gastric cancer progression through interacting with EZH2 and regulating miR-200c-3p/Notch1 axis.
ELK4 promotes the development of gastric cancer by inducing M2 polarization of macrophages through regulation of the KDM5A-PJA2-KSR1 axis.
Title: ELK4 promotes the development of gastric cancer by inducing M2 polarization of macrophages through regulation of the KDM5A-PJA2-KSR1 axis.
TRA2A-induced upregulation of LINC00662 regulates blood-brain barrier permeability by affecting ELK4 mRNA stability in Alzheimer's microenvironment.
Title: TRA2A-induced upregulation of LINC00662 regulates blood-brain barrier permeability by affecting ELK4 mRNA stability in Alzheimer's microenvironment.
Data suggest that SIRT7 undergoes Lys-63 polyubiquitination, later removed by USP7 to repress enzymatic activity of SIRT7; USP7 and SIRT7 regulate gluconeogenesis via expression of glucose-6-phosphatase catalytic subunit (G6PC); SIRT7 targets G6PC promoter through ELK4. (SIRT7 = sirtuin 7; USP7 = ubiquitin specific peptidase 7; G6PC = glucose-6-phosphatase catalytic subunit; ELK4 = transcription factor ELK4)
Title: Ubiquitin-specific peptidase 7 (USP7)-mediated deubiquitination of the histone deacetylase SIRT7 regulates gluconeogenesis.
SLC45A3-ELK4 may represent the first description of a recurrent RNA chimaeric transcript specific to prostate cancer that does not have a detectable DNA aberration
Title: Transcriptome sequencing to detect gene fusions in cancer.
ELK4 is overexpressed in melanoma and knocking down the ELK4 or CDK2 expression significantly attenuated the malignant phenotype of melanoma cells
Title: Cyclin-dependent kinase 2 (CDK2) is a key mediator for EGF-induced cell transformation mediated through the ELK4/c-Fos signaling pathway.
CTCF has a role in regulating SLC45A3-ELK4 Chimeric RNA
Title: Role of CTCF in Regulating SLC45A3-ELK4 Chimeric RNA.
Data suggest that chimeric SLC45A3-ELK4 controls prostate cancer cell proliferation, and the chimera level correlates with prostate cancer disease progression.
Title: Chimeric transcript generated by cis-splicing of adjacent genes regulates prostate cancer cell proliferation.

Submit: New GeneRIF Correction See all GeneRIFs (12)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D11S2921 (e-PCR)
- UniSTS:152074

D1S3206 (e-PCR)
- UniSTS:68131

SHGC-12882 (e-PCR)
- UniSTS:71731

D8S2279 (e-PCR)
- UniSTS:473907

SHGC-76251 (e-PCR)
- UniSTS:5207

WI-15027 (e-PCR)
- UniSTS:10341

SHGC-76234 (e-PCR)
- UniSTS:80491

RH102822 (e-PCR)
- UniSTS:97156

SHGC-76232 (e-PCR)
- UniSTS:14515

WI-18186 (e-PCR)
- UniSTS:65764

SHGC-76228 (e-PCR)
- UniSTS:72682

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables DNA binding	TAS Traceable Author Statement more info	PubMed
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IMP Inferred from Mutant Phenotype more info	PubMed
enables DNA-binding transcription factor activity	NAS Non-traceable Author Statement more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	ISA Inferred from Sequence Alignment more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific double-stranded DNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of chromatin	ISA Inferred from Sequence Alignment more info
located_in cytosol	IDA Inferred from Direct Assay more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: ETS domain-containing protein Elk-4

Names: ELK4, ETS transcription factor; ELK4, ETS-domain protein (SRF accessory protein 1); SAP-1; serum response factor accessory protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_029563.1 RefSeqGene

Range

5862..29930

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001973.4 → NP_001964.2 ETS domain-containing protein Elk-4 isoform a

See identical proteins and their annotated locations for NP_001964.2

Status: REVIEWED

Description

Transcript Variant: This variant (a) encodes the longer isoform (1).

Source sequence(s)

AC096533

Consensus CDS

CCDS1456.1

UniProtKB/Swiss-Prot

P28323, P28324, Q6GSJ2

UniProtKB/TrEMBL

Q8IXL1

Related

ENSP00000350681.4, ENST00000357992.9

Conserved Domains (2) summary

smart00413
Location:17 → 88

ETS; erythroblast transformation specific domain

pfam04929
Location:237 → 323

Herpes_DNAp_acc; Herpes DNA replication accessory factor
NM_021795.3 → NP_068567.1 ETS domain-containing protein Elk-4 isoform b

See identical proteins and their annotated locations for NP_068567.1

Status: REVIEWED

Description

Transcript Variant: This variant (b) uses an alternate splice site in the 3' coding region which results in a frameshift compared to variant 1. This results in a shorter protein (isoform b) which has a shorter and distinct C-terminus compared to isoform a.

Source sequence(s)

AC096533

Consensus CDS

CCDS1457.1

Related

ENSP00000289703.4, ENST00000289703.8

Conserved Domains (2) summary

smart00413
Location:17 → 88

ETS; erythroblast transformation specific domain

cl26464
Location:167 → 350

Atrophin-1; Atrophin-1 family