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    TRIM29 tripartite motif containing 29 [ Homo sapiens (human) ]

    Gene ID: 23650, updated on 7-Apr-2024

    Summary

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    Official Symbol
    TRIM29provided by HGNC
    Official Full Name
    tripartite motif containing 29provided by HGNC
    Primary source
    HGNC:HGNC:17274
    See related
    Ensembl:ENSG00000137699 MIM:610658; AllianceGenome:HGNC:17274
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ATDC
    Summary
    The protein encoded by this gene belongs to the TRIM protein family. It has multiple zinc finger motifs and a leucine zipper motif. It has been proposed to form homo- or heterodimers which are involved in nucleic acid binding. Thus, it may act as a transcriptional regulatory factor involved in carcinogenesis and/or differentiation. It may also function in the suppression of radiosensitivity since it is associated with ataxia telangiectasia phenotype. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in esophagus (RPKM 274.4), skin (RPKM 264.0) and 4 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    11q23.3
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (120111286..120138113, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (120134138..120160951, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (119981994..120008821, complement)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105369527 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_19353 Neighboring gene NANOG hESC enhancer GRCh37_chr11:119926297-119926798 Neighboring gene MPRA-validated peak1494 silencer Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:119932166-119933158 Neighboring gene uncharacterized LOC105378956 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr11:119952219-119953418 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:119967440-119968306 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5635 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:119994383-119994890 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr11:119995312-119996511 Neighboring gene uncharacterized LOC105369529 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_19417 Neighboring gene uncharacterized LOC107984399 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3985 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5636 Neighboring gene uncharacterized LOC124902773

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. E3 ubiquitin ligase TRIM29 promotes pancreatic cancer growth and progression via stabilizing Yes-associated protein 1. Deng X, et al. J Transl Med, 2021 Aug 5. PMID 34353343, Free PMC Article
    2. TRIM29 Reverses Oxaliplatin Resistance of P53 Mutant Colon Cancer Cell. Lei G, et al. Can J Gastroenterol Hepatol, 2021. PMID 33824865, Free PMC Article
    3. Terminal keratinocyte differentiation in vitro is associated with a stable DNA methylome. Smits JPH, et al. Exp Dermatol, 2021 Aug. PMID 32681572, Free PMC Article
    4. TRIM29 prevents hepatocellular carcinoma progression by inhibiting Wnt/β-catenin signaling pathway. Xu M, et al. Acta Biochim Biophys Sin (Shanghai), 2019 Jan 1. PMID 30566565
    5. Loss of TRIM29 Alters Keratin Distribution to Promote Cell Invasion in Squamous Cell Carcinoma. Yanagi T, et al. Cancer Res, 2018 Dec 15. PMID 30389700

    See all (102) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TRIM29 modulates proteins involved in PTEN/AKT/mTOR and JAK2/STAT3 signaling pathway and suppresses the progression of hepatocellular carcinoma.
      Title: TRIM29 modulates proteins involved in PTEN/AKT/mTOR and JAK2/STAT3 signaling pathway and suppresses the progression of hepatocellular carcinoma.
    2. TRIM29 promotes the progression of colorectal cancer by suppressing EZH2 degradation.
      Title: TRIM29 promotes the progression of colorectal cancer by suppressing EZH2 degradation.
    3. TRIM29 promotes antitumor immunity through enhancing IGF2BP1 ubiquitination and subsequent PD-L1 downregulation in gastric cancer.
      Title: TRIM29 promotes antitumor immunity through enhancing IGF2BP1 ubiquitination and subsequent PD-L1 downregulation in gastric cancer.
    4. NAP1L5 facilitates pancreatic ductal adenocarcinoma progression via TRIM29-mediated ubiquitination of PHLPP1.
      Title: NAP1L5 facilitates pancreatic ductal adenocarcinoma progression via TRIM29-mediated ubiquitination of PHLPP1.
    5. lncRNA ELFN1-AS1 upregulates TRIM29 by suppressing miR-211-3p to promote gastric cancer progression.
      Title: lncRNA ELFN1-AS1 upregulates TRIM29 by suppressing miR-211-3p to promote gastric cancer progression.
    6. Classification of early age facial growth pattern and identification of the genetic basis in two Korean populations.
      Title: Classification of early age facial growth pattern and identification of the genetic basis in two Korean populations.
    7. Terminal keratinocyte differentiation in vitro is associated with a stable DNA methylome.
      Title: Terminal keratinocyte differentiation in vitro is associated with a stable DNA methylome.
    8. TRIM29 regulates the SETBP1/SET/PP2A axis via transcription factor VEZF1 to promote progression of ovarian cancer.
      Title: TRIM29 regulates the SETBP1/SET/PP2A axis via transcription factor VEZF1 to promote progression of ovarian cancer.
    9. TRIM29 is required for efficient recruitment of 53BP1 in response to DNA double-strand breaks in vertebrate cells.
      Title: TRIM29 is required for efficient recruitment of 53BP1 in response to DNA double-strand breaks in vertebrate cells.
    10. E3 ubiquitin ligase TRIM29 promotes pancreatic cancer growth and progression via stabilizing Yes-associated protein 1.
      Title: E3 ubiquitin ligase TRIM29 promotes pancreatic cancer growth and progression via stabilizing Yes-associated protein 1.
    Submit: New GeneRIF Correction See all GeneRIFs (55)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    A genome-wide association study identifies a gene network of ADAMTS genes in the predisposition to pediatric stroke.
    EBI GWAS Catalog
    Genetic variants near PDGFRA are associated with corneal curvature in Australians.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Replication interactions

    Interaction Pubs
    Knockdown of tripartite motif containing 29 (TRIM29) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ36085

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables cadherin binding involved in cell-cell adhesion HDA PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables p53 binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell-cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of protein localization to nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in adherens junction HDA PubMed 
    located_in lysosome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    tripartite motif-containing protein 29
    Names
    ataxia-telangiectasia group D-associated protein
    tripartite motif protein TRIM29

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001330382.2 → NP_001317311.1  tripartite motif-containing protein 29 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AK299459, AP001360, BM996078, CU450129, DC420658
      Consensus CDS
      CCDS81637.1
      UniProtKB/TrEMBL
      B7Z5V5, E9PRL4
      Related
      ENSP00000436015.1, ENST00000529044.5

    2. NM_012101.4 → NP_036233.2  tripartite motif-containing protein 29 isoform 1

      See identical proteins and their annotated locations for NP_036233.2

      Status: REVIEWED

      Source sequence(s)
      AP000679, BC017352
      Consensus CDS
      CCDS8428.1
      UniProtKB/Swiss-Prot
      Q14134, Q96AA9, Q9BZY7
      UniProtKB/TrEMBL
      Q53G41
      Related
      ENSP00000343129.5, ENST00000341846.10
      Conserved Domains (2) summary
      smart00336
      Location:220 → 260
      BBOX; B-Box-type zinc finger
      cl27218
      Location:273 → 355
      OmpH; Outer membrane protein (OmpH-like)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      120111286..120138113 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047426689.1 → XP_047282645.1  tripartite motif-containing protein 29 isoform X1

    2. XM_047426688.1 → XP_047282644.1  tripartite motif-containing protein 29 isoform X5

    3. XM_005271490.2 → XP_005271547.1  tripartite motif-containing protein 29 isoform X4

      See identical proteins and their annotated locations for XP_005271547.1

      UniProtKB/TrEMBL
      B7Z5V5, B7Z8U9
      Conserved Domains (1) summary
      pfam01442
      Location:1 → 107
      Apolipoprotein; Apolipoprotein A1/A4/E domain

    4. XM_011542733.2 → XP_011541035.1  tripartite motif-containing protein 29 isoform X3

      UniProtKB/TrEMBL
      B7Z5V5
      Conserved Domains (1) summary
      cl02488
      Location:20 → 99
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

    5. XM_017017453.2 → XP_016872942.1  tripartite motif-containing protein 29 isoform X2

      UniProtKB/TrEMBL
      B7Z5V5

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      120134138..120160951 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054368258.1 → XP_054224233.1  tripartite motif-containing protein 29 isoform X1

    2. XM_054368261.1 → XP_054224236.1  tripartite motif-containing protein 29 isoform X4

      UniProtKB/TrEMBL
      B7Z8U9

    3. XM_054368260.1 → XP_054224235.1  tripartite motif-containing protein 29 isoform X3

    4. XM_054368259.1 → XP_054224234.1  tripartite motif-containing protein 29 isoform X2

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_058193.1: Suppressed sequence

      Description
      NM_058193.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q14134.2 GenPept UniProtKB/Swiss-Prot:Q14134

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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