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    TNFAIP8 TNF alpha induced protein 8 [ Homo sapiens (human) ]

    Gene ID: 25816, updated on 3-Apr-2024

    Summary

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    Official Symbol
    TNFAIP8provided by HGNC
    Official Full Name
    TNF alpha induced protein 8provided by HGNC
    Primary source
    HGNC:HGNC:17260
    See related
    Ensembl:ENSG00000145779 MIM:612111; AllianceGenome:HGNC:17260
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NDED; GG2-1; SCCS2; SCC-S2; MDC-3.13
    Summary
    Enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process. Involved in positive regulation of apoptotic process. Located in cytoplasm and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in lymph node (RPKM 31.1), fat (RPKM 24.0) and 19 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    5q23.1
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (119268759..119399688)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (119789607..119920525)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (118604454..118735383)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene Dmx like 1 Neighboring gene RNA, U6 small nuclear 701, pseudogene Neighboring gene microRNA 5706 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:118591447-118592003 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22960 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22961 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16264 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22962 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22963 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22964 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22965 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:118609555-118610054 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22966 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22967 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22968 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22969 Neighboring gene RNA, 7SL, cytoplasmic 174, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:118664591-118665278 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22971 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22972 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22973 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22975 Neighboring gene uncharacterized LOC102723444 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22974 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22976 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22977 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22978 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16265 Neighboring gene Sharpr-MPRA regulatory region 6110 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22979 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22980 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22981 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22982 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22983 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:118726761-118726918 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22984 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22985 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22986 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr5:118737716-118738284 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:118740092-118740592 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22987 Neighboring gene Sharpr-MPRA regulatory region 10011 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22989 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr5:118794469-118795121 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:118797267-118797484 Neighboring gene RNA, 5S ribosomal pseudogene 190 Neighboring gene uncharacterized LOC124901215 Neighboring gene hydroxysteroid 17-beta dehydrogenase 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Current research status of TNFAIP8 in tumours and other inflammatory conditions (Review). Hua J, et al. Int J Oncol, 2021 Jul. PMID 34036374
    2. TNFAIP8 regulates gastric cancer growth via mTOR-Akt-ULK1 pathway and autophagy signals. Chen Z, et al. J Cell Mol Med, 2021 Apr. PMID 33682317, Free PMC Article
    3. Proteomic Analysis of Plasma sEVs Reveals That TNFAIP8 Is a New Biomarker of Cell Proliferation in Diabetic Retinopathy. Xiao J, et al. J Proteome Res, 2021 Mar 5. PMID 33594895
    4. TNFAIP8 drives metabolic reprogramming to promote prostate cancer cell proliferation. Niture S, et al. Int J Biochem Cell Biol, 2021 Jan. PMID 33227392, Free PMC Article
    5. Inflection of Akt/mTOR/STAT-3 cascade in TNF-α induced protein 8 mediated human lung carcinogenesis. Bordoloi D, et al. Life Sci, 2020 Dec 1. PMID 32976884

    See all (61) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Synovial fluid exosome-derived miR-182-5p alleviates osteoarthritis by downregulating TNFAIP8 and promoting autophagy through LC3 signaling.
      Title: Synovial fluid exosome-derived miR-182-5p alleviates osteoarthritis by downregulating TNFAIP8 and promoting autophagy through LC3 signaling.
    2. Kidney tubular epithelial cells control interstitial fibroblast fate by releasing TNFAIP8-encapsulated exosomes.
      Title: Kidney tubular epithelial cells control interstitial fibroblast fate by releasing TNFAIP8-encapsulated exosomes.
    3. Decoupling tumor cell metastasis from growth by cellular pilot protein TNFAIP8.
      Title: Decoupling tumor cell metastasis from growth by cellular pilot protein TNFAIP8.
    4. Current research status of TNFAIP8 in tumours and other inflammatory conditions (Review).
      Title: Current research status of TNFAIP8 in tumours and other inflammatory conditions (Review).
    5. TNFAIP8 drives metabolic reprogramming to promote prostate cancer cell proliferation.
      Title: TNFAIP8 drives metabolic reprogramming to promote prostate cancer cell proliferation.
    6. TNFAIP8 regulates gastric cancer growth via mTOR-Akt-ULK1 pathway and autophagy signals.
      Title: TNFAIP8 regulates gastric cancer growth via mTOR-Akt-ULK1 pathway and autophagy signals.
    7. Proteomic Analysis of Plasma sEVs Reveals That TNFAIP8 Is a New Biomarker of Cell Proliferation in Diabetic Retinopathy.
      Title: Proteomic Analysis of Plasma sEVs Reveals That TNFAIP8 Is a New Biomarker of Cell Proliferation in Diabetic Retinopathy.
    8. TNFAIP8 promotes AML chemoresistance by activating ERK signaling pathway through interaction with Rac1.
      Title: TNFAIP8 promotes AML chemoresistance by activating ERK signaling pathway through interaction with Rac1.
    9. TNFAIP8 regulates cisplatin resistance through TAF-Ialpha and promotes malignant progression of esophageal cancer.
      Title: TNFAIP8 regulates cisplatin resistance through TAF-Iα and promotes malignant progression of esophageal cancer.
    10. TNFAIP8 regulates autophagy, cell steatosis, and promotes hepatocellular carcinoma cell proliferation.
      Title: TNFAIP8 regulates autophagy, cell steatosis, and promotes hepatocellular carcinoma cell proliferation.
    Submit: New GeneRIF Correction See all GeneRIFs (40)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    A genome-wide search for quantitative trait loci affecting the cortical surface area and thickness of Heschl's gyrus.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120 upregulates the expression of tumor necrosis factor, alpha-induced protein 8 (TNFAIP8) in human B cells PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of apoptotic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  

    General protein information

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    Preferred Names
    tumor necrosis factor alpha-induced protein 8
    Names
    NF-kappa-B-inducible DED-containing protein
    TNF-induced protein GG2-1
    head and neck tumor and metastasis-related protein
    tumor necrosis factor, alpha induced protein 8

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001077654.3 → NP_001071122.1  tumor necrosis factor alpha-induced protein 8 isoform b

      See identical proteins and their annotated locations for NP_001071122.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate 5'-terminal exon and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (b) has a shorter and distinct N-terminus, compared to isoform a.
      Source sequence(s)
      AC035144, BC007014, BP274520, CB241243
      Consensus CDS
      CCDS47257.1
      UniProtKB/TrEMBL
      B3KUI2
      Related
      ENSP00000274456.6, ENST00000274456.6
      Conserved Domains (1) summary
      pfam05527
      Location:7 → 185
      DUF758; Domain of unknown function (DUF758)

    2. NM_001286813.2 → NP_001273742.1  tumor necrosis factor alpha-induced protein 8 isoform a

      See identical proteins and their annotated locations for NP_001273742.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Both variants 1 and 3 encode the same isoform (a).
      Source sequence(s)
      AC035144, AK097284, BC007014, CB241243
      Consensus CDS
      CCDS47258.1
      UniProtKB/Swiss-Prot
      B3KMH1, B3KMI2, B7Z713, O95379, Q9P1Q1, Q9UER5, Q9UP47
      UniProtKB/TrEMBL
      B3KUI2
      Related
      ENSP00000421848.1, ENST00000503646.1
      Conserved Domains (1) summary
      pfam05527
      Location:17 → 195
      DUF758; Domain of unknown function (DUF758)

    3. NM_001286814.1 → NP_001273743.1  tumor necrosis factor alpha-induced protein 8 isoform c

      See identical proteins and their annotated locations for NP_001273743.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) contains an alternate 5'-terminal exon and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (c) has a longer and distinct N-terminus, compared to isoform a.
      Source sequence(s)
      AK301281, BC007014, CB241243, DC391074
      Consensus CDS
      CCDS68933.1
      UniProtKB/TrEMBL
      B3KUI2
      Related
      ENSP00000427424.1, ENST00000513374.1
      Conserved Domains (1) summary
      pfam05527
      Location:29 → 207
      DUF758; Domain of unknown function (DUF758)

    4. NM_001286815.2 → NP_001273744.1  tumor necrosis factor alpha-induced protein 8 isoform d

      See identical proteins and their annotated locations for NP_001273744.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (d) has a shorter N-terminus, compared to isoform a. Both variants 5 and 6 encode the same isoform.
      Source sequence(s)
      AC035144, BC007014, BP274520, CB241243, DB114867
      UniProtKB/TrEMBL
      B3KUI2
      Conserved Domains (1) summary
      pfam05527
      Location:1 → 163
      DUF758; Domain of unknown function (DUF758)

    5. NM_001286817.2 → NP_001273746.1  tumor necrosis factor alpha-induced protein 8 isoform d

      See identical proteins and their annotated locations for NP_001273746.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (d) has a shorter N-terminus, compared to isoform a. Both variants 5 and 6 encode the same isoform.
      Source sequence(s)
      AC035144, BC007014, BP274520, CB241243, DB124282
      UniProtKB/TrEMBL
      B3KUI2
      Conserved Domains (1) summary
      pfam05527
      Location:1 → 163
      DUF758; Domain of unknown function (DUF758)

    6. NM_014350.4 → NP_055165.2  tumor necrosis factor alpha-induced protein 8 isoform a

      See identical proteins and their annotated locations for NP_055165.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes isoform a. Both variant 1 and 3 encode the same isoform.
      Source sequence(s)
      AC035144, BC007014, CB241243
      Consensus CDS
      CCDS47258.1
      UniProtKB/Swiss-Prot
      B3KMH1, B3KMI2, B7Z713, O95379, Q9P1Q1, Q9UER5, Q9UP47
      UniProtKB/TrEMBL
      B3KUI2
      Related
      ENSP00000422245.1, ENST00000504771.3
      Conserved Domains (1) summary
      pfam05527
      Location:17 → 195
      DUF758; Domain of unknown function (DUF758)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

      Range
      119268759..119399688
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017009328.2 → XP_016864817.1  tumor necrosis factor alpha-induced protein 8 isoform X2

      UniProtKB/TrEMBL
      B3KUI2
      Conserved Domains (1) summary
      pfam05527
      Location:1 → 163
      DUF758; Domain of unknown function (DUF758)

    2. XM_047417082.1 → XP_047273038.1  tumor necrosis factor alpha-induced protein 8 isoform X2

    3. XM_017009327.2 → XP_016864816.1  tumor necrosis factor alpha-induced protein 8 isoform X1

      UniProtKB/TrEMBL
      B3KUI2

    4. XM_047417081.1 → XP_047273037.1  tumor necrosis factor alpha-induced protein 8 isoform X2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060929.1 Alternate T2T-CHM13v2.0

      Range
      119789607..119920525
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054352324.1 → XP_054208299.1  tumor necrosis factor alpha-induced protein 8 isoform X2

    2. XM_054352326.1 → XP_054208301.1  tumor necrosis factor alpha-induced protein 8 isoform X2

    3. XM_054352323.1 → XP_054208298.1  tumor necrosis factor alpha-induced protein 8 isoform X1

    4. XM_054352325.1 → XP_054208300.1  tumor necrosis factor alpha-induced protein 8 isoform X2

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O95379.1 GenPept UniProtKB/Swiss-Prot:O95379

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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