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    RASL10B RAS like family 10 member B [ Homo sapiens (human) ]

    Gene ID: 91608, updated on 5-Mar-2024

    Summary

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    Official Symbol
    RASL10Bprovided by HGNC
    Official Full Name
    RAS like family 10 member Bprovided by HGNC
    Primary source
    HGNC:HGNC:30295
    See related
    Ensembl:ENSG00000270885 MIM:612128; AllianceGenome:HGNC:30295
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RRP17; VTS58635
    Summary
    Predicted to enable G protein activity and GTP binding activity. Predicted to be involved in positive regulation of peptide hormone secretion and regulation of systemic arterial blood pressure by atrial natriuretic peptide. Predicted to be located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in fat (RPKM 7.3), heart (RPKM 2.8) and 8 other tissues See more
    Orthologs
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    Genomic context

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    Location:
    17q12
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (35731639..35743521)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (36679576..36691458)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (34058658..34070540)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene transmembrane protein 160 pseudogene Neighboring gene adaptor related protein complex 2 subunit beta 1 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr17:33957282-33958481 Neighboring gene MPRA-validated peak2820 silencer Neighboring gene Sharpr-MPRA regulatory region 1039 Neighboring gene ribosomal protein L17 pseudogene 42 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8440 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:34059551-34060074 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12079 Neighboring gene growth arrest specific 2 like 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8441 Neighboring gene chromosome 17 open reading frame 50 Neighboring gene matrix metallopeptidase 28

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Cloning and characterization of a novel small monomeric GTPase, RasL10B, with tumor suppressor potential. Zou H, et al. Biotechnol Lett, 2006 Dec. PMID 17028781
    2. Regulation of atrial natriuretic peptide secretion by a novel Ras-like protein. Rybkin II, et al. J Cell Biol, 2007 Nov 5. PMID 17984325, Free PMC Article
    3. Systematic identification of molecular links between core and candidate genes in breast cancer. Arroyo R, et al. J Mol Biol, 2015 Mar 27. PMID 25640309
    4. Comparison of substrate specificity of the ubiquitin ligases Nedd4 and Nedd4-2 using proteome arrays. Persaud A, et al. Mol Syst Biol, 2009. PMID 19953087, Free PMC Article
    5. Ubiquitin-mediated proteolysis of HuR by heat shock. Abdelmohsen K, et al. EMBO J, 2009 May 6. PMID 19322201, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. RRP17 is a component of the cellular machinery involved in regulated secretion within the heart and potential mediator of the endocrine influence of the heart on other tissues
      Title: Regulation of atrial natriuretic peptide secretion by a novel Ras-like protein.
    2. RasL10B is a new member of Ras superfamily with tumor suppressor potential
      Title: Cloning and characterization of a novel small monomeric GTPase, RasL10B, with tumor suppressor potential.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Clone Names

    • MGC47540

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of peptide hormone secretion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of systemic arterial blood pressure by atrial natriuretic peptide ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ras-like protein family member 10B
    Names
    Ras-related protein 17
    alternative protein RASL10B
    ras-like protein VTS58635
    NP_201572.1
    XP_016880789.1
    XP_047292999.1
    XP_054173738.1
    XP_054173739.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_033315.4 → NP_201572.1  ras-like protein family member 10B

      See identical proteins and their annotated locations for NP_201572.1

      Status: VALIDATED

      Source sequence(s)
      AC006237, AK122652, BC041133, DA250459
      Consensus CDS
      CCDS11297.1
      UniProtKB/Swiss-Prot
      B3KV31, Q96S79
      Related
      ENSP00000474230.1, ENST00000603017.2
      Conserved Domains (1) summary
      cd04142
      Location:5 → 203
      RRP22; Ras-related protein on chromosome 22 (RRP22) family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      35731639..35743521
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047437043.1 → XP_047292999.1  ras-like protein family member 10B isoform X1

    2. XM_017025300.2 → XP_016880789.1  ras-like protein family member 10B isoform X2

    RNA

    1. XR_934595.3 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      36679576..36691458
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054317763.1 → XP_054173738.1  ras-like protein family member 10B isoform X1

    2. XM_054317764.1 → XP_054173739.1  ras-like protein family member 10B isoform X2

    RNA

    1. XR_008484962.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q96S79.1 GenPept UniProtKB/Swiss-Prot:Q96S79

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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