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    EIF3I eukaryotic translation initiation factor 3 subunit I [ Homo sapiens (human) ]

    Gene ID: 8668, updated on 7-Apr-2024

    Summary

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    Official Symbol
    EIF3Iprovided by HGNC
    Official Full Name
    eukaryotic translation initiation factor 3 subunit Iprovided by HGNC
    Primary source
    HGNC:HGNC:3272
    See related
    Ensembl:ENSG00000084623 MIM:603911; AllianceGenome:HGNC:3272
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TRIP1; EIF3S2; TRIP-1; PRO2242; eIF3-p36; eIF3-beta
    Summary
    Contributes to translation initiation factor activity. Involved in translational initiation. Located in extracellular exosome. Part of eukaryotic translation initiation factor 3 complex. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in thyroid (RPKM 51.3), ovary (RPKM 48.1) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    1p35.2
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (32222407..32236170)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (32080311..32094075)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (32688008..32701771)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 675 Neighboring gene IQ motif containing C Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr1:32681346-32682545 Neighboring gene doublecortin domain containing 2B Neighboring gene transmembrane protein 234 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:32687227-32688426 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:32698370-32698870 Neighboring gene myotubularin related protein 9 like, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 676 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 586 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 677 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 678 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 679 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 680 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 681 Neighboring gene family with sequence similarity 167 member B Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 587 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 588 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 589 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 682 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 683 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 684 Neighboring gene LCK proto-oncogene, Src family tyrosine kinase Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 590

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Insights into the Structure and Function of TRIP-1, a Newly Identified Member in Calcified Tissues. Arivalagan J, et al. Biomolecules, 2023 Feb 22. PMID 36979349, Free PMC Article
    2. TRIP-1 in the extracellular matrix promotes nucleation of calcium phosphate polymorphs. Ramachandran A, et al. Connect Tissue Res, 2018 Dec. PMID 29745814
    3. EIF3i affects vesicular stomatitis virus growth by interacting with matrix protein. Pan W, et al. Vet Microbiol, 2017 Dec. PMID 29173589, Free PMC Article
    4. TRIP-1 regulates TGF-β1-induced epithelial-mesenchymal transition of human lung epithelial cell line A549. Perez RE, et al. Am J Physiol Lung Cell Mol Physiol, 2011 May. PMID 21378021
    5. Higher TRIP-1 level explains diminished collagen contraction ability of fetal versus adult fibroblasts. Navarro A, et al. Am J Physiol Lung Cell Mol Physiol, 2009 Jun. PMID 19329541

    See all (181) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. METTL3-mediated m[6]A modification of lncRNA TSPAN12 promotes metastasis of hepatocellular carcinoma through SENP1-depentent deSUMOylation of EIF3I.
      Title: METTL3-mediated m(6)A modification of lncRNA TSPAN12 promotes metastasis of hepatocellular carcinoma through SENP1-depentent deSUMOylation of EIF3I.
    2. eIF3i promotes colorectal cancer cell survival via augmenting PHGDH translation.
      Title: eIF3i promotes colorectal cancer cell survival via augmenting PHGDH translation.
    3. circEIF3I facilitates the recruitment of SMAD3 to early endosomes to promote TGF-beta signalling pathway-mediated activation of MMPs in pancreatic cancer.
      Title: circEIF3I facilitates the recruitment of SMAD3 to early endosomes to promote TGF-β signalling pathway-mediated activation of MMPs in pancreatic cancer.
    4. Insights into the Structure and Function of TRIP-1, a Newly Identified Member in Calcified Tissues.
      Title: Insights into the Structure and Function of TRIP-1, a Newly Identified Member in Calcified Tissues.
    5. eIF3i regulation of protein synthesis, cell proliferation, cell cycle progression, and tumorigenesis.
      Title: eIF3i regulation of protein synthesis, cell proliferation, cell cycle progression, and tumorigenesis.
    6. varying concentrations of TRIP-1 can participate in the nucleation of calcium phosphate polymorphs.
      Title: TRIP-1 in the extracellular matrix promotes nucleation of calcium phosphate polymorphs.
    7. EIF3i may affect vesicular stomatitis virus (VSV) growth by regulating the host antiviral response in HeLa cells.
      Title: EIF3i affects vesicular stomatitis virus growth by interacting with matrix protein.
    8. High eIF3i expression is associated with melanoma.
      Title: eIF3i activity is critical for endothelial cells in tumor induced angiogenesis through regulating VEGFR and ERK translation.
    9. Clusterin is an independent predictive factor for prognosis of hepatocellular carcinoma and it facilitates metastasis through EIF3I/Akt/MMP13 signaling.
      Title: Clusterin facilitates metastasis by EIF3I/Akt/MMP13 signaling in hepatocellular carcinoma.
    10. eIF3i is a proto-oncogene that drives colon oncogenesis by translationally upregulating COX-2 and activating the beta-catenin signaling pathway
      Title: EIF3i promotes colon oncogenesis by regulating COX-2 protein synthesis and β-catenin activation.
    Submit: New GeneRIF Correction See all GeneRIFs (15)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Pol gag-pol HIV-1 Pol is identified to have a physical interaction with eukaryotic translation initiation factor 3, subunit I (EIF3I) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
    Rev rev HIV-1 Rev interacting protein, eukaryotic translation initiation factor 3, subunit I (EIF3I), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables translation initiation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to translation initiation factor activity IC
    Inferred by Curator
    more info
    		 PubMed 
    contributes_to translation initiation factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables translation initiation factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cytoplasmic translational initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in formation of cytoplasmic translation initiation complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in translational initiation IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in translational initiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    part_of eukaryotic 43S preinitiation complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of eukaryotic 48S preinitiation complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of eukaryotic translation initiation factor 3 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of eukaryotic translation initiation factor 3 complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of eukaryotic translation initiation factor 3 complex, eIF3m IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular exosome HDA PubMed 
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    eukaryotic translation initiation factor 3 subunit I
    Names
    TGF-beta receptor-interacting protein 1
    TGFbeta receptor-interacting protein 1
    eukaryotic translation initiation factor 3 subunit 2
    eukaryotic translation initiation factor 3, subunit 2 (beta, 36kD)
    eukaryotic translation initiation factor 3, subunit 2 beta, 36kDa
    predicted protein of HQ2242

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001394168.1 → NP_001381097.1  eukaryotic translation initiation factor 3 subunit I isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL049795, AL121991
      Consensus CDS
      CCDS90907.1
      UniProtKB/TrEMBL
      A0A7I2YQI2, A0A7I2YQI6
      Related
      ENSP00000503706.1, ENST00000678063.1
      Conserved Domains (2) summary
      sd00039
      Location:14 → 50
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:6 → 299
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    2. NM_003757.4 → NP_003748.1  eukaryotic translation initiation factor 3 subunit I isoform 1

      See identical proteins and their annotated locations for NP_003748.1

      Status: VALIDATED

      Source sequence(s)
      AL049795, AL121991
      Consensus CDS
      CCDS357.1
      UniProtKB/Swiss-Prot
      Q13347
      UniProtKB/TrEMBL
      A0A7P0MRT9, Q53HU7, Q5U0F4
      Related
      ENSP00000504061.1, ENST00000677711.2
      Conserved Domains (2) summary
      sd00039
      Location:14 → 50
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:6 → 311
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      32222407..32236170
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024450518.2 → XP_024306286.1  eukaryotic translation initiation factor 3 subunit I isoform X1

      Related
      ENST00000676957.1
      Conserved Domains (2) summary
      sd00039
      Location:58 → 94
      7WD40; WD40 repeat [structural motif]
      cl25539
      Location:34 → 178
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      32080311..32094075
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054339351.1 → XP_054195326.1  eukaryotic translation initiation factor 3 subunit I isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q13347.1 GenPept UniProtKB/Swiss-Prot:Q13347

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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