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    LPCAT4 lysophosphatidylcholine acyltransferase 4 [ Homo sapiens (human) ]

    Gene ID: 254531, updated on 3-Apr-2024

    Summary

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    Official Symbol
    LPCAT4provided by HGNC
    Official Full Name
    lysophosphatidylcholine acyltransferase 4provided by HGNC
    Primary source
    HGNC:HGNC:30059
    See related
    Ensembl:ENSG00000176454 MIM:612039; AllianceGenome:HGNC:30059
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    AYTL3; AGPAT7; LPEAT2; LPLAT10; LPAAT-eta
    Summary
    Members of the 1-acylglycerol-3-phosphate O-acyltransferase (EC 2.3.1.51) family, such as AGPAT7, catalyze the conversion of lysophosphatidic acid (LPA) to phosphatidic acid (PA), a precursor in the biosynthesis of all glycerolipids. Both LPA and PA are involved in signal transduction (Ye et al., 2005 [PubMed 16243729]).[supplied by OMIM, May 2008]
    Expression
    Ubiquitous expression in stomach (RPKM 27.5), duodenum (RPKM 20.5) and 23 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    15q14
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (34358633..34367196, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (32159092..32167666, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (34650834..34659397, complement)

    Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6279 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6280 Neighboring gene NOP10 ribonucleoprotein Neighboring gene NUT midline carcinoma family member 1 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr15:34645972-34647171 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6281 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6282 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6283 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr15:34659557-34660552 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9181 Neighboring gene actin gamma 1 pseudogene 15 Neighboring gene golgin A8 family member A Neighboring gene microRNA 1233-1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. LPCAT4 Knockdown Alters Barrier Integrity and Cellular Bioenergetics in Human Urothelium. Mason AS, et al. Int J Mol Sci, 2022 Oct 6. PMID 36233185, Free PMC Article
    2. Accumulated phosphatidylcholine (16:0/16:1) in human colorectal cancer; possible involvement of LPCAT4. Kurabe N, et al. Cancer Sci, 2013 Oct. PMID 23815430, Free PMC Article
    3. Cloning and characterization a novel human 1-acyl-sn-glycerol-3-phosphate acyltransferase gene AGPAT7. Ye GM, et al. DNA Seq, 2005 Oct. PMID 16243729
    4. Molecular identification of a novel mammalian brain isoform of acyl-CoA:lysophospholipid acyltransferase with prominent ethanolamine lysophospholipid acylating activity, LPEAT2. Cao J, et al. J Biol Chem, 2008 Jul 4. PMID 18458083
    5. Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence. Adams MD, et al. Nature, 1995 Sep 28. PMID 7566098

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. LPCAT4 Knockdown Alters Barrier Integrity and Cellular Bioenergetics in Human Urothelium.
      Title: LPCAT4 Knockdown Alters Barrier Integrity and Cellular Bioenergetics in Human Urothelium.
    2. LPCAT4 is overexpressed and involved in the deregulation of PC(16:0/16:1) in colorectal cancer.
      Title: Accumulated phosphatidylcholine (16:0/16:1) in human colorectal cancer; possible involvement of LPCAT4.
    3. LPEAT2 as an important enzyme in the biosynthesis of ethanolamine-containing phospholipids, especially in brain.
      Title: Molecular identification of a novel mammalian brain isoform of acyl-CoA:lysophospholipid acyltransferase with prominent ethanolamine lysophospholipid acylating activity, LPEAT2.
    4. report the cloning and characterization of a novel human 1-acyl-sn-glycerol-3-phosphate acyltransferase member AGPAT7 (1-acyl-sn-glycerol-3-phosphate acyltransferase 7) gene, which was mapped to human chromosome 15q14
      Title: Cloning and characterization a novel human 1-acyl-sn-glycerol-3-phosphate acyltransferase gene AGPAT7.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ10257

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables 1-acylglycerol-3-phosphate O-acyltransferase activity TAS
    Traceable Author Statement
    more info
    		  
    enables 1-acylglycerophosphocholine O-acyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 1-acylglycerophosphoethanolamine O-acyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 1-acylglycerophosphoserine O-acyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 1-alkenylglycerophosphoethanolamine O-acyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 1-alkylglycerophosphocholine O-acetyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 2-acylglycerol-3-phosphate O-acyltransferase activity TAS
    Traceable Author Statement
    more info
    		  
    enables lysophosphatidic acid acyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables lysophospholipid acyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables lysophospholipid acyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in phosphatidic acid biosynthetic process TAS
    Traceable Author Statement
    more info
    		  
    involved_in phosphatidylcholine acyl-chain remodeling IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in phosphatidylcholine acyl-chain remodeling TAS
    Traceable Author Statement
    more info
    		  
    involved_in phosphatidylethanolamine acyl-chain remodeling IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in phosphatidylethanolamine acyl-chain remodeling TAS
    Traceable Author Statement
    more info
    		  
    involved_in phosphatidylglycerol acyl-chain remodeling TAS
    Traceable Author Statement
    more info
    		  
    involved_in phosphatidylserine acyl-chain remodeling IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in phosphatidylserine acyl-chain remodeling TAS
    Traceable Author Statement
    more info
    		  
    acts_upstream_of_or_within phospholipid metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within phospholipid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in membrane HDA PubMed 

    General protein information

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    Preferred Names
    lysophospholipid acyltransferase LPCAT4
    Names
    1-AGP acyltransferase 7
    1-AGPAT 7
    1-acylglycerol-3-phosphate O-acyltransferase 7 (lysophosphatidic acid acyltransferase, eta)
    1-acylglycerophosphocholine O-acyltransferase
    1-acylglycerophosphoserine O-acyltransferase
    1-alkenylglycerophosphoethanolamine O-acyltransferase
    1-alkylglycerophosphocholine O-acetyltransferase
    PLSC domain containing protein
    acyl-CoA:lysophosphatidylethanolamine acyltransferase 2
    acyltransferase-like 3
    lysophosphatidylethanolamine acyltransferase 2
    lysophospholipid acyltransferase 10
    plasmalogen synthase
    NP_705841.2
    XP_006720517.1
    XP_047288290.1
    XP_054189157.1
    XP_054189158.1
    XP_054233625.1
    XP_054233626.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_153613.3 → NP_705841.2  lysophospholipid acyltransferase LPCAT4

      See identical proteins and their annotated locations for NP_705841.2

      Status: VALIDATED

      Source sequence(s)
      AC025678, BC048430, BC092463, T29943
      Consensus CDS
      CCDS32191.1
      UniProtKB/Swiss-Prot
      A8K2K8, O43412, Q643R3, Q7Z4P4, Q8IUL7, Q8TB38
      Related
      ENSP00000317300.6, ENST00000314891.11
      Conserved Domains (1) summary
      cd07991
      Location:109 → 306
      LPLAT_LPCAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

      Range
      34358633..34367196 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047432334.1 → XP_047288290.1  lysophospholipid acyltransferase LPCAT4 isoform X1

    2. XM_006720454.2 → XP_006720517.1  lysophospholipid acyltransferase LPCAT4 isoform X2

      UniProtKB/TrEMBL
      B7ZM32
      Conserved Domains (2) summary
      cd07991
      Location:109 → 306
      LPLAT_LPCAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like
      COG0204
      Location:109 → 237
      PlsC; 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]

    RNA

    1. XR_007064436.1 RNA Sequence

    2. XR_931784.2 RNA Sequence

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_025791798.1 Reference GRCh38.p14 PATCHES

      Range
      99459..108034 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054333182.1 → XP_054189157.1  lysophospholipid acyltransferase LPCAT4 isoform X1

    2. XM_054333183.1 → XP_054189158.1  lysophospholipid acyltransferase LPCAT4 isoform X2

    RNA

    1. XR_008485830.1 RNA Sequence

    2. XR_008485831.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060939.1 Alternate T2T-CHM13v2.0

      Range
      32159092..32167666 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054377650.1 → XP_054233625.1  lysophospholipid acyltransferase LPCAT4 isoform X1

    2. XM_054377651.1 → XP_054233626.1  lysophospholipid acyltransferase LPCAT4 isoform X2

    RNA

    1. XR_008488934.1 RNA Sequence

    2. XR_008488935.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q643R3.1 GenPept UniProtKB/Swiss-Prot:Q643R3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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