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    TPST1 tyrosylprotein sulfotransferase 1 [ Homo sapiens (human) ]

    Gene ID: 8460, updated on 11-Apr-2024

    Summary

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    Official Symbol
    TPST1provided by HGNC
    Official Full Name
    tyrosylprotein sulfotransferase 1provided by HGNC
    Primary source
    HGNC:HGNC:12020
    See related
    Ensembl:ENSG00000169902 MIM:603125; AllianceGenome:HGNC:12020
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TANGO13A
    Summary
    Enables protein homodimerization activity and protein-tyrosine sulfotransferase activity. Involved in peptidyl-tyrosine sulfation. Is integral component of Golgi membrane. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in gall bladder (RPKM 13.2), urinary bladder (RPKM 9.5) and 22 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    7q11.21
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (66198790..66360443)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (67420877..67582531)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (65670321..65825430)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18203 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26080 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:65551291-65551918 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:65565192-65565753 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:65578710-65578900 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26081 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:65580214-65580742 Neighboring gene argininosuccinate lyase Neighboring gene MED14-independent group 3 enhancer GRCh37_chr7:65612993-65614192 Neighboring gene CGRP receptor component Neighboring gene ReSE screen-validated silencer GRCh37_chr7:65642926-65643089 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18204 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18205 Neighboring gene MPRA-validated peak6545 silencer Neighboring gene NANOG hESC enhancer GRCh37_chr7:65779787-65780442 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:65814565-65815064 Neighboring gene RNA, U6 small nuclear 313, pseudogene Neighboring gene ReSE screen-validated silencer GRCh37_chr7:65827447-65827611 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:65853152-65853652 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:65853653-65854153 Neighboring gene long intergenic non-protein coding RNA 174 Neighboring gene uncharacterized LOC124901822 Neighboring gene general transcription factor IIi pseudogene 9

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Identification and characterization of tyrosylprotein sulfotransferase from human saliva. Kasinathan C, et al. Int J Biol Sci, 2005. PMID 16244708, Free PMC Article
    2. Tyrosylprotein sulfotransferase 1 expression is negatively correlated with c‑Met and lymph node metastasis in human lung cancer. Jiang Z, et al. Mol Med Rep, 2015 Oct. PMID 26238632
    3. Genetic variation in microRNA-binding site and prognosis of patients with colorectal cancer. Kim JG, et al. J Cancer Res Clin Oncol, 2015 Jan. PMID 25079514
    4. Mass spectrometric kinetic analysis of human tyrosylprotein sulfotransferase-1 and -2. Danan LM, et al. J Am Soc Mass Spectrom, 2008 Oct. PMID 18672380, Free PMC Article
    5. Human TPST1 transmembrane domain triggers enzyme dimerisation and localisation to the Golgi compartment. Goettsch S, et al. J Mol Biol, 2006 Aug 18. PMID 16859706

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TPST1 was significantly negatively correlated with the expression of cMet in lung cancer and may be a negative prognostic biomarker of lung cancer.
      Title: Tyrosylprotein sulfotransferase 1 expression is negatively correlated with c‑Met and lymph node metastasis in human lung cancer.
    2. TPST1 rs3757417T>G polymorphisms are associated with colorectal cancer.
      Title: Genetic variation in microRNA-binding site and prognosis of patients with colorectal cancer.
    3. up-regulation of TPST-1 and tyrosine sulfation of CXCR4 by LMP1 might be a potential mechanism contributing to nasopharyngeal carcinoma metastasis
      Title: Tyrosylprotein sulfotransferase-1 and tyrosine sulfation of chemokine receptor 4 are induced by Epstein-Barr virus encoded latent membrane protein 1 and associated with the metastatic potential of human nasopharyngeal carcinoma.
    4. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    5. Affinity purified salivary TPST showed a single band of 50-54 kDa and is the first report characterizing a tyrosylprotein sulfotransferase in secretory fluid from the parotid gland
      Title: Identification and characterization of tyrosylprotein sulfotransferase from human saliva.
    6. Observational study of gene-disease association. (HuGE Navigator)
      Title: Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects.
    7. The kinetic parameters of tyrosylprotein sulfotransferase-1 and -2, catalyzing tyrosine sulfation of CCR8 peptides, were determined using liquid chromatography electrospray ionisation mass spectrometry.
      Title: Mass spectrometric kinetic analysis of human tyrosylprotein sulfotransferase-1 and -2.
    8. results exclude TPST1 as the causative gene for Shwachman-Diamond syndrome
      Title: Fine mapping of the locus for Shwachman-Diamond syndrome at 7q11, identification of shared disease haplotypes, and exclusion of TPST1 as a candidate gene.
    9. Human tyrosylprotein sulfotransferase may be functional as homodimer/oligomer in the trans-Golgi compartment.
      Title: Human TPST1 transmembrane domain triggers enzyme dimerisation and localisation to the Golgi compartment.
    10. Tyrosine sulfation of CCR5 N-terminal peptide follows a discrete pattern and temporal sequence
      Title: Tyrosine sulfation of CCR5 N-terminal peptide by tyrosylprotein sulfotransferases 1 and 2 follows a discrete pattern and temporal sequence.
    Submit: New GeneRIF Correction See all GeneRIFs (11)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env The chemokine receptor CCR5 is posttranslationally modified by sulfation of its N-terminal tyrosines; sulfated tyrosines contribute to the binding of CCR5 to MIP-1 alpha, MIP-1 beta, and HIV-1 gp120/CD4 complexes and to the ability of HIV-1 to enter cells PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein homodimerization activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein-tyrosine sulfotransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-tyrosine sulfotransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein-tyrosine sulfotransferase activity TAS
    Traceable Author Statement
    more info
    		  
    Process Evidence Code Pubs
    involved_in 3'-phosphoadenosine 5'-phosphosulfate metabolic process TAS
    Traceable Author Statement
    more info
    		  
    involved_in peptidyl-tyrosine sulfation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in post-translational protein modification IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Golgi membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in membrane TAS
    Traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    protein-tyrosine sulfotransferase 1
    Names
    TPST-1
    transport and golgi organization 13 homolog A
    NP_003587.1
    XP_005250699.1
    XP_011514936.1
    XP_011514937.1
    XP_016868215.1
    XP_016868216.1
    XP_047276912.1
    XP_047276913.1
    XP_047276914.1
    XP_047276915.1
    XP_047276916.1
    XP_047276918.1
    XP_047276919.1
    XP_054215199.1
    XP_054215200.1
    XP_054215201.1
    XP_054215202.1
    XP_054215203.1
    XP_054215204.1
    XP_054215205.1
    XP_054215206.1
    XP_054215207.1
    XP_054215208.1
    XP_054215209.1
    XP_054215210.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_003596.4 → NP_003587.1  protein-tyrosine sulfotransferase 1

      See identical proteins and their annotated locations for NP_003587.1

      Status: VALIDATED

      Source sequence(s)
      BC013188
      Consensus CDS
      CCDS5533.1
      UniProtKB/Swiss-Prot
      A4D2M0, O60507, Q6FGM7
      UniProtKB/TrEMBL
      Q75M96
      Related
      ENSP00000302413.5, ENST00000304842.6
      Conserved Domains (1) summary
      pfam13469
      Location:72 → 261
      Sulfotransfer_3; Sulfotransferase family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      66198790..66360443
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047420959.1 → XP_047276915.1  protein-tyrosine sulfotransferase 1 isoform X2

      UniProtKB/Swiss-Prot
      A4D2M0, O60507, Q6FGM7

    2. XM_047420957.1 → XP_047276913.1  protein-tyrosine sulfotransferase 1 isoform X1

    3. XM_047420960.1 → XP_047276916.1  protein-tyrosine sulfotransferase 1 isoform X2

      UniProtKB/Swiss-Prot
      A4D2M0, O60507, Q6FGM7

    4. XM_047420962.1 → XP_047276918.1  protein-tyrosine sulfotransferase 1 isoform X2

      UniProtKB/Swiss-Prot
      A4D2M0, O60507, Q6FGM7

    5. XM_047420958.1 → XP_047276914.1  protein-tyrosine sulfotransferase 1 isoform X2

      UniProtKB/Swiss-Prot
      A4D2M0, O60507, Q6FGM7

    6. XM_017012726.3 → XP_016868215.1  protein-tyrosine sulfotransferase 1 isoform X2

      UniProtKB/Swiss-Prot
      A4D2M0, O60507, Q6FGM7
      UniProtKB/TrEMBL
      Q75M96
      Conserved Domains (1) summary
      pfam13469
      Location:72 → 261
      Sulfotransfer_3; Sulfotransferase family

    7. XM_017012727.3 → XP_016868216.1  protein-tyrosine sulfotransferase 1 isoform X2

      UniProtKB/Swiss-Prot
      A4D2M0, O60507, Q6FGM7
      UniProtKB/TrEMBL
      Q75M96
      Conserved Domains (1) summary
      pfam13469
      Location:72 → 261
      Sulfotransfer_3; Sulfotransferase family

    8. XM_011516635.4 → XP_011514937.1  protein-tyrosine sulfotransferase 1 isoform X3

      See identical proteins and their annotated locations for XP_011514937.1

      UniProtKB/TrEMBL
      Q75M96
      Conserved Domains (1) summary
      pfam13469
      Location:72 → 261
      Sulfotransfer_3; Sulfotransferase family

    9. XM_047420963.1 → XP_047276919.1  protein-tyrosine sulfotransferase 1 isoform X3

    10. XM_011516634.4 → XP_011514936.1  protein-tyrosine sulfotransferase 1 isoform X3

      See identical proteins and their annotated locations for XP_011514936.1

      UniProtKB/TrEMBL
      Q75M96
      Conserved Domains (1) summary
      pfam13469
      Location:72 → 261
      Sulfotransfer_3; Sulfotransferase family

    11. XM_005250642.4 → XP_005250699.1  protein-tyrosine sulfotransferase 1 isoform X1

      See identical proteins and their annotated locations for XP_005250699.1

      UniProtKB/TrEMBL
      Q75M96
      Conserved Domains (1) summary
      pfam13469
      Location:69 → 257
      Sulfotransfer_3; Sulfotransferase family

    12. XM_047420956.1 → XP_047276912.1  protein-tyrosine sulfotransferase 1 isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      67420877..67582531
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054359230.1 → XP_054215205.1  protein-tyrosine sulfotransferase 1 isoform X2

      UniProtKB/Swiss-Prot
      A4D2M0, O60507, Q6FGM7

    2. XM_054359226.1 → XP_054215201.1  protein-tyrosine sulfotransferase 1 isoform X1

    3. XM_054359231.1 → XP_054215206.1  protein-tyrosine sulfotransferase 1 isoform X2

      UniProtKB/Swiss-Prot
      A4D2M0, O60507, Q6FGM7

    4. XM_054359232.1 → XP_054215207.1  protein-tyrosine sulfotransferase 1 isoform X2

      UniProtKB/Swiss-Prot
      A4D2M0, O60507, Q6FGM7

    5. XM_054359227.1 → XP_054215202.1  protein-tyrosine sulfotransferase 1 isoform X2

      UniProtKB/Swiss-Prot
      A4D2M0, O60507, Q6FGM7

    6. XM_054359228.1 → XP_054215203.1  protein-tyrosine sulfotransferase 1 isoform X2

      UniProtKB/Swiss-Prot
      A4D2M0, O60507, Q6FGM7

    7. XM_054359229.1 → XP_054215204.1  protein-tyrosine sulfotransferase 1 isoform X2

      UniProtKB/Swiss-Prot
      A4D2M0, O60507, Q6FGM7

    8. XM_054359234.1 → XP_054215209.1  protein-tyrosine sulfotransferase 1 isoform X3

    9. XM_054359235.1 → XP_054215210.1  protein-tyrosine sulfotransferase 1 isoform X3

    10. XM_054359233.1 → XP_054215208.1  protein-tyrosine sulfotransferase 1 isoform X3

    11. XM_054359224.1 → XP_054215199.1  protein-tyrosine sulfotransferase 1 isoform X1

    12. XM_054359225.1 → XP_054215200.1  protein-tyrosine sulfotransferase 1 isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O60507.1 GenPept UniProtKB/Swiss-Prot:O60507

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