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    Kcnmb2 potassium large conductance calcium-activated channel, subfamily M, beta member 2 [ Mus musculus (house mouse) ]

    Gene ID: 72413, updated on 12-May-2024

    Summary

    Official Symbol
    Kcnmb2provided by MGI
    Official Full Name
    potassium large conductance calcium-activated channel, subfamily M, beta member 2provided by MGI
    Primary source
    MGI:MGI:1919663
    See related
    Ensembl:ENSMUSG00000037610 AllianceGenome:MGI:1919663
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2700049B16Rik; 3110031N04Rik
    Summary
    Predicted to enable calcium-activated potassium channel activity and potassium channel regulator activity. Predicted to be involved in detection of calcium ion; neuronal action potential; and potassium ion transport. Predicted to act upstream of or within ion transport. Predicted to be integral component of plasma membrane. Predicted to be part of voltage-gated potassium channel complex. Is expressed in ascending aorta and ductus arteriosus. Orthologous to human KCNMB2 (potassium calcium-activated channel subfamily M regulatory beta subunit 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Location:
    3 A3; 3 15.48 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (31956021..32254329)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (31901861..32200180)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_07327 Neighboring gene predicted gene, 54171 Neighboring gene predicted gene 6558 Neighboring gene STARR-seq mESC enhancer starr_07328 Neighboring gene predicted gene, 33886 Neighboring gene predicted gene, 34031 Neighboring gene STARR-seq mESC enhancer starr_07329 Neighboring gene STARR-seq mESC enhancer starr_07330 Neighboring gene STARR-seq mESC enhancer starr_07331 Neighboring gene STARR-seq mESC enhancer starr_07332 Neighboring gene predicted gene, 42201 Neighboring gene predicted gene, 37770 Neighboring gene predicted gene, 57708

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (3)  1 citation

    General gene information

    Markers

    Clone Names

    • MGC57945

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium-activated potassium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables calcium-activated potassium channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables potassium channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables potassium channel regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in action potential ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in detection of calcium ion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in detection of calcium ion ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within monoatomic ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in neuronal action potential ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in potassium ion transport ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    part_of voltage-gated potassium channel complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of voltage-gated potassium channel complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    calcium-activated potassium channel subunit beta-2
    Names
    BK channel subunit beta-2
    BKbeta2
    calcium-activated potassium channel, subfamily M subunit beta-2
    charybdotoxin receptor subunit beta-2
    k(VCA)beta-2
    maxi K channel subunit beta-2
    slo-beta-2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001429175.1NP_001416104.1  calcium-activated potassium channel subunit beta-2

      Status: VALIDATED

      Source sequence(s)
      AC115930, AC156552, AC158571
    2. NM_028231.3NP_082507.1  calcium-activated potassium channel subunit beta-2

      See identical proteins and their annotated locations for NP_082507.1

      Status: VALIDATED

      Source sequence(s)
      AC115930, AC156552, AC158571
      Consensus CDS
      CCDS17292.1
      UniProtKB/Swiss-Prot
      Q9CZM9
      Related
      ENSMUSP00000113234.2, ENSMUST00000119970.8
      Conserved Domains (2) summary
      pfam03185
      Location:38229
      CaKB; Calcium-activated potassium channel, beta subunit
      pfam09303
      Location:232
      KcnmB2_inactiv; KCNMB2, ball and chain domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      31956021..32254329
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006535550.3XP_006535613.1  calcium-activated potassium channel subunit beta-2 isoform X2

      See identical proteins and their annotated locations for XP_006535613.1

      UniProtKB/Swiss-Prot
      Q9CZM9
      Conserved Domains (2) summary
      pfam03185
      Location:38229
      CaKB; Calcium-activated potassium channel, beta subunit
      pfam09303
      Location:232
      KcnmB2_inactiv; KCNMB2, ball and chain domain
    2. XM_006535549.5XP_006535612.1  calcium-activated potassium channel subunit beta-2 isoform X2

      UniProtKB/Swiss-Prot
      Q9CZM9
      Related
      ENSMUSP00000112531.2, ENSMUST00000119310.8
      Conserved Domains (2) summary
      pfam03185
      Location:38229
      CaKB; Calcium-activated potassium channel, beta subunit
      pfam09303
      Location:232
      KcnmB2_inactiv; KCNMB2, ball and chain domain
    3. XM_006535548.5XP_006535611.1  calcium-activated potassium channel subunit beta-2 isoform X1

      Conserved Domains (2) summary
      pfam09303
      Location:3161
      KcnmB2_inactiv; KCNMB2, ball and chain domain
      pfam03185
      Location:67258
      CaKB; Calcium-activated potassium channel, beta subunit
    4. XM_036163350.1XP_036019243.1  calcium-activated potassium channel subunit beta-2 isoform X2

      UniProtKB/Swiss-Prot
      Q9CZM9
      Conserved Domains (2) summary
      pfam03185
      Location:38229
      CaKB; Calcium-activated potassium channel, beta subunit
      pfam09303
      Location:232
      KcnmB2_inactiv; KCNMB2, ball and chain domain
    5. XM_006535551.4XP_006535614.1  calcium-activated potassium channel subunit beta-2 isoform X2

      See identical proteins and their annotated locations for XP_006535614.1

      UniProtKB/Swiss-Prot
      Q9CZM9
      Conserved Domains (2) summary
      pfam03185
      Location:38229
      CaKB; Calcium-activated potassium channel, beta subunit
      pfam09303
      Location:232
      KcnmB2_inactiv; KCNMB2, ball and chain domain
    6. XM_017319742.3XP_017175231.1  calcium-activated potassium channel subunit beta-2 isoform X2

      UniProtKB/Swiss-Prot
      Q9CZM9
      Conserved Domains (2) summary
      pfam03185
      Location:38229
      CaKB; Calcium-activated potassium channel, beta subunit
      pfam09303
      Location:232
      KcnmB2_inactiv; KCNMB2, ball and chain domain