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    Hnrnpul2 heterogeneous nuclear ribonucleoprotein U-like 2 [ Mus musculus (house mouse) ]

    Gene ID: 68693, updated on 30-Apr-2024

    Summary

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    Official Symbol
    Hnrnpul2provided by MGI
    Official Full Name
    heterogeneous nuclear ribonucleoprotein U-like 2provided by MGI
    Primary source
    MGI:MGI:1915943
    See related
    Ensembl:ENSMUSG00000071659 AllianceGenome:MGI:1915943
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Hnrpul2; 1110031M08Rik
    Summary
    Predicted to enable RNA binding activity. Located in nucleus. Is expressed in central nervous system; olfactory epithelium; retina layer; and submandibular gland primordium. Orthologous to human HNRNPUL2 (heterogeneous nuclear ribonucleoprotein U like 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 45.1), CNS E14 (RPKM 27.9) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    19 A; 19 5.7 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (8796765..8811507)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (8819401..8834143)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene polymerase (RNA) II (DNA directed) polypeptide G Neighboring gene STARR-positive B cell enhancer ABC_E173 Neighboring gene zinc finger and BTB domain containing 3 Neighboring gene tetratricopeptide repeat domain 9C Neighboring gene STARR-seq mESC enhancer starr_45496 Neighboring gene BSCL2 lipid droplet biogenesis associated, seipin Neighboring gene guanine nucleotide binding protein (G protein), gamma 3 Neighboring gene LRRN4 C-terminal like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Myeloid leukemia factor 1 associates with a novel heterogeneous nuclear ribonucleoprotein U-like molecule. Winteringham LN, et al. J Biol Chem, 2006 Dec 15. PMID 17008314
    2. TERRA transcripts are bound by a complex array of RNA-binding proteins. López de Silanes I, et al. Nat Commun, 2010 Jun 29. PMID 20975687
    3. Misregulation of Alternative Splicing in a Mouse Model of Rett Syndrome. Li R, et al. PLoS Genet, 2016 Jun. PMID 27352031, Free PMC Article
    4. Identification of novel Ack1-interacting proteins and Ack1 phosphorylated sites in mouse brain by mass spectrometry. Del Mar Masdeu M, et al. Oncotarget, 2017 Nov 24. PMID 29254152, Free PMC Article
    5. In-depth protein profiling of the postsynaptic density from mouse hippocampus using data-independent acquisition proteomics. Distler U, et al. Proteomics, 2014 Nov. PMID 25211037

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in alternative mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in synapse EXP
    Inferred from Experiment
    more info
    		 PubMed 
    is_active_in synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    heterogeneous nuclear ribonucleoprotein U-like protein 2
    Names
    MLF1-associated nuclear protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081196.1 → NP_001074665.1  heterogeneous nuclear ribonucleoprotein U-like protein 2

      See identical proteins and their annotated locations for NP_001074665.1

      Status: VALIDATED

      Source sequence(s)
      AC129217
      Consensus CDS
      CCDS37908.1
      UniProtKB/Swiss-Prot
      F8VPM4, Q00PI9
      Related
      ENSMUSP00000094515.4, ENSMUST00000096753.5
      Conserved Domains (4) summary
      smart00513
      Location:3 → 37
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      pfam13671
      Location:452 → 597
      AAA_33; AAA domain
      cd12884
      Location:244 → 415
      SPRY_hnRNP; SPRY domain in heterogeneous nuclear ribonucleoprotein U-like (hnRNP) protein 1
      cl17190
      Location:452 → 634
      NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      8796765..8811507
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_003952813.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q00PI9.2 GenPept UniProtKB/Swiss-Prot:Q00PI9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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