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    Zfp691 zinc finger protein 691 [ Mus musculus (house mouse) ]

    Gene ID: 195522, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Zfp691provided by MGI
    Official Full Name
    zinc finger protein 691provided by MGI
    Primary source
    MGI:MGI:3041163
    See related
    Ensembl:ENSMUSG00000045268 AllianceGenome:MGI:3041163
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Znf691; 6430544H17Rik
    Summary
    Predicted to enable DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Orthologous to human ZNF691 (zinc finger protein 691). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in testis adult (RPKM 8.1), ovary adult (RPKM 7.1) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    4 D2.1; 4 55.34 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (119026710..119031429, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (119169516..119174195, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E6204 Neighboring gene predicted gene, 52706 Neighboring gene STARR-positive B cell enhancer ABC_E3506 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:118781841-118782024 Neighboring gene solute carrier family 2 (facilitated glucose transporter), member 1 Neighboring gene STARR-seq mESC enhancer starr_11226 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:118800270-118800453 Neighboring gene predicted gene 12867 Neighboring gene STARR-positive B cell enhancer ABC_E422 Neighboring gene erythroblast membrane-associated protein Neighboring gene small vasohibin binding protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article
    2. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518
    3. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
    4. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
    5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC118413

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 691

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001145935.1 → NP_001139407.1  zinc finger protein 691

      See identical proteins and their annotated locations for NP_001139407.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All three variants encode the same protein.
      Source sequence(s)
      AK032431, AL606975, BC108395
      Consensus CDS
      CCDS18570.1
      UniProtKB/TrEMBL
      A2A7P4
      Related
      ENSMUSP00000136119.2, ENSMUST00000179290.8
      Conserved Domains (3) summary
      COG5048
      Location:70 → 234
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:197 → 217
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:251 → 273
      zf-C2H2; Zinc finger, C2H2 type

    2. NM_001145936.1 → NP_001139408.1  zinc finger protein 691

      See identical proteins and their annotated locations for NP_001139408.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All three variants encode the same protein.
      Source sequence(s)
      AK032431, AL606975, BY233872
      Consensus CDS
      CCDS18570.1
      UniProtKB/TrEMBL
      A2A7P4
      Related
      ENSMUSP00000101962.4, ENSMUST00000106355.5
      Conserved Domains (3) summary
      COG5048
      Location:70 → 234
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:197 → 217
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:251 → 273
      zf-C2H2; Zinc finger, C2H2 type

    3. NM_183140.3 → NP_898963.2  zinc finger protein 691

      See identical proteins and their annotated locations for NP_898963.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. All three variants encode the same protein.
      Source sequence(s)
      AK032431, AL606975, BC108395
      Consensus CDS
      CCDS18570.1
      UniProtKB/TrEMBL
      A2A7P4
      Related
      ENSMUSP00000053013.5, ENSMUST00000052715.10
      Conserved Domains (3) summary
      COG5048
      Location:70 → 234
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:197 → 217
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:251 → 273
      zf-C2H2; Zinc finger, C2H2 type

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      119026710..119031429 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036163923.1 → XP_036019816.1  zinc finger protein 691 isoform X1

      UniProtKB/TrEMBL
      A2A7P4
      Conserved Domains (3) summary
      COG5048
      Location:70 → 234
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:197 → 217
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:251 → 273
      zf-C2H2; Zinc finger, C2H2 type
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3TDE8.1 GenPept UniProtKB/Swiss-Prot:Q3TDE8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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