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    Il17re interleukin 17 receptor E [ Mus musculus (house mouse) ]

    Gene ID: 57890, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Il17reprovided by MGI
    Official Full Name
    interleukin 17 receptor Eprovided by MGI
    Primary source
    MGI:MGI:1889371
    See related
    Ensembl:ENSMUSG00000043088 AllianceGenome:MGI:1889371
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Il25r; IL-17RE
    Summary
    Predicted to enable interleukin-17 receptor activity. Predicted to act upstream of or within inflammatory response. Predicted to be located in cytoplasm; extracellular region; and plasma membrane. Predicted to be integral component of membrane. Is expressed in urinary system. Orthologous to human IL17RE (interleukin 17 receptor E). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in stomach adult (RPKM 20.6), bladder adult (RPKM 19.2) and 14 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Il17re in Genome Data Viewer
    Location:
    6 E3; 6 52.76 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (113435659..113447719)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (113458699..113470758)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene cell death-inducing DFFA-like effector c Neighboring gene predicted gene, 52871 Neighboring gene STARR-positive B cell enhancer ABC_E8122 Neighboring gene jagunal homolog 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:113408068-113408221 Neighboring gene predicted gene, 52872 Neighboring gene interleukin 17 receptor C Neighboring gene STARR-positive B cell enhancer ABC_E684 Neighboring gene STARR-seq mESC enhancer starr_17041 Neighboring gene cysteine-rich with EGF-like domains 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The IL-17 receptor IL-17RE mediates polyIC-induced exacerbation of experimental allergic asthma. Vella G, et al. Respir Res, 2020 Jul 8. PMID 32641167, Free PMC Article
    2. Clinical significance of Interleukin 17 receptor E in diabetic nephropathy. Wang J, et al. Int Immunopharmacol, 2023 Jul. PMID 37235960
    3. Interleukin-17 Receptor E and C-C Motif Chemokine Receptor 10 Identify Heterogeneous T Helper 17 Subsets in a Mouse Dry Eye Disease Model. Wang J, et al. Am J Pathol, 2022 Feb. PMID 35144761
    4. IL-25 Receptor Signaling Modulates Host Defense against Cryptococcus neoformans Infection. Hansakon A, et al. J Immunol, 2020 Aug 1. PMID 32561567
    5. Interleukin 17 Receptor E (IL-17RE) and IL-17C Mediate the Recruitment of Neutrophils during Acute Streptococcus pneumoniae Pneumonia. Steck P, et al. Infect Immun, 2019 Nov. PMID 31481409, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Clinical significance of Interleukin 17 receptor E in diabetic nephropathy.
      Title: Clinical significance of Interleukin 17 receptor E in diabetic nephropathy.
    2. Interleukin-17 Receptor E and C-C Motif Chemokine Receptor 10 Identify Heterogeneous T Helper 17 Subsets in a Mouse Dry Eye Disease Model.
      Title: Interleukin-17 Receptor E and C-C Motif Chemokine Receptor 10 Identify Heterogeneous T Helper 17 Subsets in a Mouse Dry Eye Disease Model.
    3. The IL-17 receptor IL-17RE mediates polyIC-induced exacerbation of experimental allergic asthma.
      Title: The IL-17 receptor IL-17RE mediates polyIC-induced exacerbation of experimental allergic asthma.
    4. IL-25 Receptor Signaling Modulates Host Defense against Cryptococcus neoformans Infection.
      Title: IL-25 Receptor Signaling Modulates Host Defense against Cryptococcus neoformans Infection.
    5. IL-17C/IL-17RE: Emergence of a Unique Axis in TH17 Biology.
      Title: IL-17C/IL-17RE: Emergence of a Unique Axis in T(H)17 Biology.
    6. These data indicate that the IL-17C/IL-17RE axis promotes the recruitment of neutrophils without affecting the recovery of alveolar macrophages in the acute phase of S. pneumoniae lung infection.
      Title: Interleukin 17 Receptor E (IL-17RE) and IL-17C Mediate the Recruitment of Neutrophils during Acute Streptococcus pneumoniae Pneumonia.
    7. In mouse models of crescentic GN (nephrotoxic nephritis) and pristane-induced lupus nephritis, deficiency of the unique IL-17C receptor IL-17 receptor E (IL-17RE) provided protection against crescentic GN. IL-17RE was highly expressed by CD4(+) TH17 cells.
      Title: IL-17C/IL-17 Receptor E Signaling in CD4(+) T Cells Promotes T(H)17 Cell-Driven Glomerular Inflammation.
    8. IL-17C and IL-17RE are dispensable for immunity to candidiasis
      Title: Signaling through IL-17C/IL-17RE is dispensable for immunity to systemic, oral and cutaneous candidiasis.
    9. IL-17RE as a receptor of IL-17C that regulates early innate immunity to intestinal pathogens.
      Title: IL-17RE is the functional receptor for IL-17C and mediates mucosal immunity to infection with intestinal pathogens.
    10. IL-17C-IL-17RE induced the expression of a nuclear IkappaB family member, IkappaBzeta, in Th17 cells to potentiate the Th17 cell response
      Title: Interleukin-17C promotes Th17 cell responses and autoimmune disease via interleukin-17 receptor E.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (5)  1 citation
    • Endonuclease-mediated (2) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables interleukin-17 receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within inflammatory response IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    interleukin-17 receptor E
    Names
    IL-17 receptor E

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001034029.2 → NP_001029201.1  interleukin-17 receptor E isoform 2

      See identical proteins and their annotated locations for NP_001029201.1

      Status: VALIDATED

      Source sequence(s)
      AC153910, AK044815, DQ092340
      Consensus CDS
      CCDS20421.1
      UniProtKB/Swiss-Prot
      Q8BH06
      Related
      ENSMUSP00000054378.5, ENSMUST00000053569.7
      Conserved Domains (2) summary
      pfam08357
      Location:247 → 374
      SEFIR; SEFIR domain
      pfam15037
      Location:1 → 207
      IL17_R_N; Interleukin-17 receptor extracellular region

    2. NM_001034031.2 → NP_001029203.1  interleukin-17 receptor E isoform 2

      See identical proteins and their annotated locations for NP_001029203.1

      Status: VALIDATED

      Source sequence(s)
      AC153910, AK044815, DQ092341
      Consensus CDS
      CCDS20421.1
      UniProtKB/Swiss-Prot
      Q8BH06
      Related
      ENSMUSP00000098626.2, ENSMUST00000101065.8
      Conserved Domains (2) summary
      pfam08357
      Location:247 → 374
      SEFIR; SEFIR domain
      pfam15037
      Location:1 → 207
      IL17_R_N; Interleukin-17 receptor extracellular region

    3. NM_001362204.1 → NP_001349133.1  interleukin-17 receptor E isoform 3 precursor

      Status: VALIDATED

      Source sequence(s)
      AC153910, AK044815, BC069861
      Consensus CDS
      CCDS90102.1
      Related
      ENSMUSP00000145345.2, ENSMUST00000203661.3
      Conserved Domains (2) summary
      pfam15037
      Location:56 → 408
      IL17_R_N; Interleukin-17 receptor extracellular region
      cl23749
      Location:406 → 529
      TIR_2; TIR domain

    4. NM_001362205.1 → NP_001349134.1  interleukin-17 receptor E isoform 4 precursor

      Status: VALIDATED

      Source sequence(s)
      AC153910, AF458068, AK044815
      Consensus CDS
      CCDS90101.1
      Related
      ENSMUSP00000145384.2, ENSMUST00000204774.3
      Conserved Domains (2) summary
      pfam08357
      Location:428 → 555
      SEFIR; SEFIR domain
      pfam15037
      Location:56 → 408
      IL17_R_N; Interleukin-17 receptor extracellular region

    5. NM_145826.6 → NP_665825.2  interleukin-17 receptor E isoform 1 precursor

      See identical proteins and their annotated locations for NP_665825.2

      Status: VALIDATED

      Source sequence(s)
      AC153910
      Consensus CDS
      CCDS20420.1
      UniProtKB/Swiss-Prot
      Q3I5F0, Q6NSU9, Q8BH06, Q8C5D0, Q8K4C1, Q8R335
      Related
      ENSMUSP00000062103.8, ENSMUST00000058548.14
      Conserved Domains (2) summary
      pfam08357
      Location:448 → 575
      SEFIR; SEFIR domain
      pfam15037
      Location:27 → 408
      IL17_R_N; Interleukin-17 receptor extracellular region

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      113435659..113447719
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030255519.2 → XP_030111379.1  interleukin-17 receptor E isoform X1

      Conserved Domains (2) summary
      pfam08357
      Location:247 → 374
      SEFIR; SEFIR domain
      pfam15037
      Location:1 → 207
      IL17_R_N; Interleukin-17 receptor extracellular region

    2. XM_036152248.1 → XP_036008141.1  interleukin-17 receptor E isoform X1

      Conserved Domains (2) summary
      pfam08357
      Location:247 → 374
      SEFIR; SEFIR domain
      pfam15037
      Location:1 → 207
      IL17_R_N; Interleukin-17 receptor extracellular region
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BH06.1 GenPept UniProtKB/Swiss-Prot:Q8BH06

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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