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    Klhl31 kelch-like 31 [ Mus musculus (house mouse) ]

    Gene ID: 244923, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Klhl31provided by MGI
    Official Full Name
    kelch-like 31provided by MGI
    Primary source
    MGI:MGI:3045305
    See related
    Ensembl:ENSMUSG00000044938 AllianceGenome:MGI:3045305
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Kbtbd1; 9830147P19Rik; D930047P17Rik
    Summary
    Predicted to be involved in negative regulation of JNK cascade and negative regulation of protein phosphorylation. Located in cytoplasm and nucleus. Is expressed in axial skeleton; diaphragm; forearm rest of mesenchyme; and skeletal musculature. Used to study centronuclear myopathy. Orthologous to human KLHL31 (kelch like family member 31). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in heart adult (RPKM 11.5), mammary gland adult (RPKM 5.8) and 3 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    9 E1; 9 43.36 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (77544014..77567407)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (77636732..77660125)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:77317674-77317857 Neighboring gene leucine rich repeat containing 1 Neighboring gene STARR-seq mESC enhancer starr_24696 Neighboring gene STARR-seq mESC enhancer starr_24697 Neighboring gene STARR-seq mESC enhancer starr_24699 Neighboring gene STARR-positive B cell enhancer mm9_chr9:77398917-77399217 Neighboring gene STARR-seq mESC enhancer starr_24700 Neighboring gene chimerin (chimaerin) 1 pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:77440338-77440521 Neighboring gene STARR-positive B cell enhancer ABC_E2905 Neighboring gene STARR-seq mESC enhancer starr_24701 Neighboring gene STARR-seq mESC enhancer starr_24702 Neighboring gene STARR-positive B cell enhancer ABC_E6770 Neighboring gene STARR-seq mESC enhancer starr_24703 Neighboring gene STARR-seq mESC enhancer starr_24704 Neighboring gene STARR-positive B cell enhancer ABC_E3846 Neighboring gene glutamate-cysteine ligase, catalytic subunit Neighboring gene STARR-seq mESC enhancer starr_24706 Neighboring gene predicted gene, 34654

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Deficiency in Kelch protein Klhl31 causes congenital myopathy in mice. Papizan JB, et al. J Clin Invest, 2017 Oct 2. PMID 28872460, Free PMC Article
    2. A novel human BTB-kelch protein KLHL31, strongly expressed in muscle and heart, inhibits transcriptional activities of TRE and SRE. Yu W, et al. Mol Cells, 2008 Nov 30. PMID 18719355
    3. A novel zebrafish kelchlike gene klhl and its human ortholog KLHL display conserved expression patterns in skeletal and cardiac muscles. Wu YL, et al. Gene, 2004 Aug 18. PMID 15302408
    4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in negative regulation of JNK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of JNK cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    kelch-like protein 31
    Names
    kelch repeat and BTB (POZ) domain containing 1
    kelch repeat and BTB domain-containing protein 1
    kelch-like protein KLHL

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_172925.2 → NP_766513.2  kelch-like protein 31

      See identical proteins and their annotated locations for NP_766513.2

      Status: VALIDATED

      Source sequence(s)
      AK053085, CT030709
      Consensus CDS
      CCDS23352.1
      UniProtKB/Swiss-Prot
      Q148Q5, Q8BWA5
      UniProtKB/TrEMBL
      G3X9D8
      Related
      ENSMUSP00000059643.7, ENSMUST00000057781.8
      Conserved Domains (6) summary
      smart00612
      Location:420 → 466
      Kelch; Kelch domain
      PHA03098
      Location:73 → 601
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:356 → 405
      Kelch; KELCH repeat [structural motif]
      pfam00651
      Location:63 → 164
      BTB; BTB/POZ domain
      pfam01344
      Location:502 → 552
      Kelch_1; Kelch motif
      pfam07707
      Location:172 → 273
      BACK; BTB And C-terminal Kelch

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      77544014..77567407
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_177238.2: Suppressed sequence

      Description
      NM_177238.2: This RefSeq was permanently suppressed because it is primarily UTR sequence.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BWA5.1 GenPept UniProtKB/Swiss-Prot:Q8BWA5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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