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    Sv2b synaptic vesicle glycoprotein 2b [ Rattus norvegicus (Norway rat) ]

    Gene ID: 117556, updated on 3-Apr-2024

    Summary

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    Official Symbol
    Sv2bprovided by RGD
    Official Full Name
    synaptic vesicle glycoprotein 2bprovided by RGD
    Primary source
    RGD:619716
    See related
    Ensembl:ENSRNOG00000011160 AllianceGenome:RGD:619716
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable transmembrane transporter activity. Predicted to be involved in neurotransmitter uptake. Located in membrane and synaptic vesicle. Is integral component of synaptic vesicle membrane. Orthologous to human SV2B (synaptic vesicle glycoprotein 2B). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Restricted expression toward (RPKM 462.5) See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    1q31
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (138388268..138562635, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (128978471..129152479, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (136664199..136842247, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene actin, gamma 1, pseudogene 11 Neighboring gene large ribosomal subunit protein eL13-like Neighboring gene A-kinase anchoring protein 13 Neighboring gene uncharacterized LOC134485139 Neighboring gene family with sequence similarity 24, member A like 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Synaptic vesicle protein 2b is expressed temporospatially in (pre)odontoblasts in developing molars. Yang SY, et al. Eur J Oral Sci, 2012 Dec. PMID 23167466
    2. Analysis of Synaptotagmin, SV2, and Rab3 Expression in Cortical Glutamatergic and GABAergic Axon Terminals. Bragina L, et al. Front Cell Neurosci, 2011. PMID 22275882, Free PMC Article
    3. Brain synaptic junctional proteins at the acrosome of rat testicular germ cells. Redecker P, et al. J Histochem Cytochem, 2003 Jun. PMID 12754292
    4. Identification of a new synaptic vesicle protein 2B mRNA transcript which is up-regulated in neurons by amyloid beta peptide fragment (1-42). Heese K, et al. Biochem Biophys Res Commun, 2001 Dec 21. PMID 11741278
    5. Synaptic vesicle protein SV2B, but not SV2A, is predominantly expressed and associated with microvesicles in rat pinealocytes. Hayashi M, et al. J Neurochem, 1998 Jul. PMID 9648885

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Reductions in Synaptic Vesicle Glycoprotein 2 Isoforms in the Cortex and Hippocampus in a Rat Model of Traumatic Brain Injury.
      Title: Reductions in Synaptic Vesicle Glycoprotein 2 Isoforms in the Cortex and Hippocampus in a Rat Model of Traumatic Brain Injury.
    2. For the first time, synaptic vesicle protein (SV) 2b, an important transmembrane transporter of Ca2+-stimulated vesicle exocytosis, was identified as a differentially expressed molecule localized in fully differentiated odontoblasts and pre-odontoblasts.
      Title: Synaptic vesicle protein 2b is expressed temporospatially in (pre)odontoblasts in developing molars.
    3. Synaptic vesicle protein 2 binds adenine nucleotides
      Title: Synaptic vesicle protein 2 binds adenine nucleotides.
    4. findings show that botulinum neurotoxin (BoNT/A) enters neurons by binding to the synaptic vesicle protein SV2 (isoforms A, B, and C);SV2 acts as the protein receptor for BoNT/A
      Title: SV2 is the protein receptor for botulinum neurotoxin A.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chemical synaptic transmission IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in neurotransmitter transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in neurotransmitter uptake TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of presynaptic cytosolic calcium ion concentration IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of presynaptic cytosolic calcium ion concentration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of synaptic vesicle exocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of synaptic vesicle exocytosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in acrosomal vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in synaptic vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in synaptic vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in synaptic vesicle membrane EXP
    Inferred from Experiment
    more info
    		 PubMed 
    is_active_in synaptic vesicle membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in synaptic vesicle membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in synaptic vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in terminal bouton HDA PubMed 

    General protein information

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    Preferred Names
    synaptic vesicle glycoprotein 2B
    Names
    synaptic vesicle protein 2B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_057207.3 → NP_476555.1  synaptic vesicle glycoprotein 2B

      See identical proteins and their annotated locations for NP_476555.1

      Status: VALIDATED

      Source sequence(s)
      AI716529, BF285601, BG671769, CB609053, CO402345, DV721065, L10362
      UniProtKB/Swiss-Prot
      Q63564
      Related
      ENSRNOP00000083518.1, ENSRNOT00000015084.7
      Conserved Domains (2) summary
      cd06174
      Location:112 → 305
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      TIGR01299
      Location:8 → 683
      synapt_SV2; synaptic vesicle protein SV2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      138388268..138562635 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017588701.3 → XP_017444190.1  synaptic vesicle glycoprotein 2B isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZWR6, A6JBZ8
      Conserved Domains (1) summary
      TIGR01299
      Location:8 → 683
      synapt_SV2; synaptic vesicle protein SV2

    2. XM_008759493.4 → XP_008757715.1  synaptic vesicle glycoprotein 2B isoform X1

      See identical proteins and their annotated locations for XP_008757715.1

      UniProtKB/TrEMBL
      A0A8I5ZWR6, A6JBZ8
      Conserved Domains (1) summary
      TIGR01299
      Location:8 → 683
      synapt_SV2; synaptic vesicle protein SV2

    3. XM_017588700.3 → XP_017444189.1  synaptic vesicle glycoprotein 2B isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZWR6, A6JBZ8
      Conserved Domains (1) summary
      TIGR01299
      Location:8 → 683
      synapt_SV2; synaptic vesicle protein SV2

    4. XM_039080109.2 → XP_038936037.1  synaptic vesicle glycoprotein 2B isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZWR6, A6JBZ8
      Conserved Domains (1) summary
      TIGR01299
      Location:8 → 683
      synapt_SV2; synaptic vesicle protein SV2

    5. XM_008759492.4 → XP_008757714.1  synaptic vesicle glycoprotein 2B isoform X1

      See identical proteins and their annotated locations for XP_008757714.1

      UniProtKB/TrEMBL
      A0A8I5ZWR6, A6JBZ8
      Conserved Domains (1) summary
      TIGR01299
      Location:8 → 683
      synapt_SV2; synaptic vesicle protein SV2

    6. XM_063268675.1 → XP_063124745.1  synaptic vesicle glycoprotein 2B isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZWR6, A6JBZ8

    7. XM_063268635.1 → XP_063124705.1  synaptic vesicle glycoprotein 2B isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZWR6, A6JBZ8
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q63564.1 GenPept UniProtKB/Swiss-Prot:Q63564

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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