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    Pknox1 Pbx/knotted 1 homeobox [ Mus musculus (house mouse) ]

    Gene ID: 18771, updated on 11-Apr-2024

    Summary

    Official Symbol
    Pknox1provided by MGI
    Official Full Name
    Pbx/knotted 1 homeoboxprovided by MGI
    Primary source
    MGI:MGI:1201409
    See related
    Ensembl:ENSMUSG00000006705 AllianceGenome:MGI:1201409
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PREP1; D17Wsu76e
    Summary
    Enables DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin binding activity. Acts upstream of or within several processes, including angiogenesis; hemopoiesis; and positive regulation of transcription by RNA polymerase II. Located in cytoplasm and nucleus. Part of transcription regulator complex. Is expressed in several structures, including alimentary system; branchial arch; genitourinary system; nervous system; and sensory organ. Orthologous to human PKNOX1 (PBX/knotted 1 homeobox 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in thymus adult (RPKM 12.1), testis adult (RPKM 10.4) and 28 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Pknox1 in Genome Data Viewer
    Location:
    17 B1; 17 16.78 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (31783697..31826665)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (31564722..31607693)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E3197 Neighboring gene NADH:ubiquinone oxidoreductase core subunit V3 Neighboring gene predicted gene, 50105 Neighboring gene STARR-positive B cell enhancer ABC_E9439 Neighboring gene STARR-seq mESC enhancer starr_42341 Neighboring gene STARR-seq mESC enhancer starr_42343 Neighboring gene cystathionine beta-synthase Neighboring gene STARR-seq mESC enhancer starr_42345 Neighboring gene ribosomal protein S2, pseudogene 8

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (4) 
    • Targeted (7)  1 citation
    • Endonuclease-mediated (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of transcription regulator complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    homeobox protein PKNOX1
    Names
    PBX/knotted homeobox 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001411456.1NP_001398385.1  homeobox protein PKNOX1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC166172, AC166575
      UniProtKB/Swiss-Prot
      O70477, Q7TT01
    2. NM_001411457.1NP_001398386.1  homeobox protein PKNOX1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC166172, AC166575
      UniProtKB/Swiss-Prot
      O70477, Q7TT01
    3. NM_001411458.1NP_001398387.1  homeobox protein PKNOX1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC166172, AC166575
      UniProtKB/Swiss-Prot
      O70477, Q7TT01
    4. NM_001411459.1NP_001398388.1  homeobox protein PKNOX1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC166172, AC166575
      UniProtKB/Swiss-Prot
      O70477, Q7TT01
    5. NM_001411460.1NP_001398389.1  homeobox protein PKNOX1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC166172, AC166575
      UniProtKB/TrEMBL
      A0A494B9U0
      Related
      ENSMUSP00000157748.2, ENSMUST00000237248.2
    6. NM_001411461.1NP_001398390.1  homeobox protein PKNOX1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC166172, AC166575
      UniProtKB/TrEMBL
      A0A494B9U0
    7. NM_001411462.1NP_001398391.1  homeobox protein PKNOX1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC166172, AC166575
      UniProtKB/TrEMBL
      A0A494B9U0
    8. NM_001411463.1NP_001398392.1  homeobox protein PKNOX1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC166172, AC166575
      UniProtKB/TrEMBL
      A0A494B9U0
    9. NM_001411464.1NP_001398393.1  homeobox protein PKNOX1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC166172, AC166575
    10. NM_001411465.1NP_001398394.1  homeobox protein PKNOX1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC166172, AC166575
    11. NM_001411466.1NP_001398395.1  homeobox protein PKNOX1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC166172, AC166575
    12. NM_001411467.1NP_001398396.1  homeobox protein PKNOX1 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC166172, AC166575
    13. NM_001411468.1NP_001398397.1  homeobox protein PKNOX1 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC166172, AC166575
      Related
      ENSMUSP00000157491.2, ENSMUST00000237038.2
    14. NM_001411469.1NP_001398398.1  homeobox protein PKNOX1 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC166172, AC166575
    15. NM_001411864.1NP_001398793.1  homeobox protein PKNOX1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC166172, AC166575
      UniProtKB/Swiss-Prot
      O70477, Q7TT01
      Related
      ENSMUSP00000134852.2, ENSMUST00000175806.9
    16. NM_016670.4NP_057879.2  homeobox protein PKNOX1 isoform 1

      See identical proteins and their annotated locations for NP_057879.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the functional protein.
      Source sequence(s)
      AC166172, AC166575
      Consensus CDS
      CCDS28608.1
      UniProtKB/Swiss-Prot
      O70477, Q7TT01
      Related
      ENSMUSP00000094966.4, ENSMUST00000097352.11
      Conserved Domains (2) summary
      pfam05920
      Location:277316
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:80165
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      31783697..31826665
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036160407.1XP_036016300.1  homeobox protein PKNOX1 isoform X4

      Conserved Domains (2) summary
      pfam05920
      Location:274313
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:80165
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NR_027493.1: Suppressed sequence

      Description
      NR_027493.1: This RefSeq was removed because it is now thought that this transcript does encode a protein.