Nostrin nitric oxide synthase trafficker [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Nostrinprovided by MGI
Official Full Name: nitric oxide synthase traffickerprovided by MGI
Primary source: MGI:MGI:3606242
See related: Ensembl:ENSMUSG00000034738 AllianceGenome:MGI:3606242
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Daip2; mDaIP2
Summary: Enables DNA binding activity. Acts upstream of or within negative regulation of transcription, DNA-templated. Located in nucleus. Orthologous to human NOSTRIN (nitric oxide synthase trafficking). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in placenta adult (RPKM 11.0), large intestine adult (RPKM 4.4) and 11 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 C2; 2 39.58 cM

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (68966144..69019674)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (69135800..69189330)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

the SH3 domain of NOSTRIN is involved in the NOSTRIN-TRAF6 interaction and is required for NOSTRIN-induced down-regulation of endothelial cell proteins
Title: Nitric-oxide synthase trafficking inducer is a pleiotropic regulator of endothelial cell function and signaling.
NOSTRIN is crucial for the localization and function of the muscarinic M3 receptor at the plasma membrane in the aorta.
Title: The F-BAR Protein NOSTRIN Dictates the Localization of the Muscarinic M3 Receptor and Regulates Cardiovascular Function.
mouse NOSTRIN acts as a transcriptional repressor by binding to the cis-element through its bZIP motif.
Title: Identification of the cis-element and bZIP DNA binding motifs for the autogenous negative control of mouse NOSTRIN.
NOSTRIN participates in FGF signal transduction and vascular development.
Title: The F-BAR protein NOSTRIN participates in FGF signal transduction and vascular development.
Results reveal an elegant mechanism of eNOS regulation by PECAM-1 through signal transducers and activators of transcription 3-mediated transcriptional control of NOSTRIN.
Title: Platelet-endothelial cell adhesion molecule-1 regulates endothelial NO synthase activity and localization through signal transducers and activators of transcription 3-dependent NOSTRIN expression.
The disabled 2 interacting protein 2 represses the expression of its own gene, via a feedback mechanism which involves binding to the promoter region.
Title: Mouse disabled 2 interacting protein 2 functions as a transcriptional repressor through direct binding onto its own promoter.
shares 82% identity with human NOSTRIN; functions in a different fashion from NOSTRIN and its function may be concerted with that of disabled 2(disabled 2 interacting protein 2)
Title: Cloning and characterization of mouse disabled 2 interacting protein 2, a mouse orthologue of human NOSTRIN.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation
Endonuclease-mediated (4)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in actin filament organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell migration	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within endocytosis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: nostrin

Names: Dab2-interacting protein 2; disabled homolog 2-interacting protein 2; eNOS-trafficking inducer; probable ortholog of human nitric oxide synthase trafficker (NOSTRIN)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_181547.3 → NP_853525.3 nostrin

See identical proteins and their annotated locations for NP_853525.3

Status: VALIDATED

Source sequence(s)

BC069942, BY061165

Consensus CDS

CCDS16087.1

UniProtKB/Swiss-Prot

Q6WKZ7, Q7TSK5, Q8BWC2

Related

ENSMUSP00000036923.8, ENSMUST00000041865.8

Conserved Domains (2) summary

cd07658
Location:8 → 250

F-BAR_NOSTRIN; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Nitric Oxide Synthase TRaffic INducer (NOSTRIN)

cd11823
Location:443 → 494

SH3_Nostrin; Src homology 3 domain of Nitric Oxide Synthase TRaffic INducer