U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Plscr4 phospholipid scramblase 4 [ Mus musculus (house mouse) ]

    Gene ID: 235527, updated on 11-Apr-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Plscr4provided by MGI
    Official Full Name
    phospholipid scramblase 4provided by MGI
    Primary source
    MGI:MGI:2143267
    See related
    Ensembl:ENSMUSG00000032377 AllianceGenome:MGI:2143267
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable CD4 receptor binding activity; enzyme binding activity; and phospholipid scramblase activity. Acts upstream of or within cellular response to lipopolysaccharide. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. Is expressed in esophagus. Orthologous to human PLSCR4 (phospholipid scramblase 4). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in bladder adult (RPKM 12.3), lung adult (RPKM 8.2) and 15 other tissues See more
    Orthologs
    human all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Location:
    9 E3.3; 9 48.39 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (92339431..92374509)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (92457372..92493513)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene phospholipid scramblase 2 Neighboring gene phospholipid scramblase 1 like 1 Neighboring gene STARR-seq mESC enhancer starr_24898 Neighboring gene predicted gene 15493 Neighboring gene STARR-seq mESC enhancer starr_24899 Neighboring gene RIKEN cDNA B430319G15 gene Neighboring gene predicted gene, 25417 Neighboring gene procollagen lysine, 2-oxoglutarate 5-dioxygenase 2

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Phospholipid scramblase expression in the pregnant mouse uterus in LPS-induced preterm delivery. McLean KC, et al. Reprod Sci, 2012 Nov. PMID 22598484, Free PMC Article
    2. Expression of the phospholipid scramblase (PLSCR) gene family during the acute phase response. Lu B, et al. Biochim Biophys Acta, 2007 Sep. PMID 17590392
    3. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
    4. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

    Go to the top of the page Help

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables CD4 receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phospholipid scramblase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to lipopolysaccharide IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in plasma membrane phospholipid scrambling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    phospholipid scramblase 4
    Names
    PL scramblase 4
    ca(2+)-dependent phospholipid scramblase 4

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001410496.1 → NP_001397425.1  phospholipid scramblase 4 isoform 2

      Status: VALIDATED

      Source sequence(s)
      CT009720

    2. NM_178711.4 → NP_848826.1  phospholipid scramblase 4 isoform 1

      See identical proteins and their annotated locations for NP_848826.1

      Status: VALIDATED

      Source sequence(s)
      CT009720
      Consensus CDS
      CCDS23407.1
      UniProtKB/Swiss-Prot
      P58196, Q3TMI2, Q8BH62
      UniProtKB/TrEMBL
      Q8BW59
      Related
      ENSMUSP00000034941.8, ENSMUST00000034941.9
      Conserved Domains (2) summary
      pfam03803
      Location:96 → 318
      Scramblase; Scramblase
      pfam11029
      Location:27 → 113
      DAZAP2; DAZ associated protein 2 (DAZAP2)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      92339431..92374509
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P58196.2 GenPept UniProtKB/Swiss-Prot:P58196

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous