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    Pgm2l1 phosphoglucomutase 2-like 1 [ Mus musculus (house mouse) ]

    Gene ID: 70974, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Pgm2l1provided by MGI
    Official Full Name
    phosphoglucomutase 2-like 1provided by MGI
    Primary source
    MGI:MGI:1918224
    See related
    Ensembl:ENSMUSG00000030729 AllianceGenome:MGI:1918224
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    BM32A; 4931406N15Rik
    Summary
    Predicted to enable glucose-1,6-bisphosphate synthase activity. Predicted to be involved in organic substance metabolic process. Predicted to act upstream of or within glucose metabolic process. Is expressed in several structures, including nervous system; sensory organ; and urinary system. Orthologous to human PGM2L1 (phosphoglucomutase 2 like 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in cortex adult (RPKM 17.9), CNS E18 (RPKM 14.6) and 12 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Pgm2l1 in Genome Data Viewer
    Location:
    7 E2; 7 54.33 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (99876471..99928079)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (100227273..100278872)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene cyclin B1 pseudogene Neighboring gene predicted gene, 34877 Neighboring gene STARR-seq mESC enhancer starr_19666 Neighboring gene glutathione peroxidase 2, pseudogene 1 Neighboring gene STARR-positive B cell enhancer ABC_E4953 Neighboring gene procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide III Neighboring gene protein phosphatase methylesterase 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Cellular heterogeneity in the ureteric progenitor niche and distinct profiles of branching morphogenesis in organ development. Rutledge EA, et al. Development, 2017 Sep 1. PMID 28705898, Free PMC Article
    2. ADAM10 hyperactivation acts on piccolo to deplete synaptic vesicle stores in Huntington's disease. Cozzolino F, et al. Hum Mol Genet, 2021 Jun 17. PMID 33601422
    3. The sperm-associated antigen 6 interactome and its role in spermatogenesis. Liu Y, et al. Reproduction, 2019 Aug. PMID 31146259, Free PMC Article
    4. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article
    5. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables glucose-1,6-bisphosphate synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glucose-1,6-bisphosphate synthase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables intramolecular phosphotransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within glucose metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in organic substance metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    glucose 1,6-bisphosphate synthase
    NP_081905.1
    XP_006508267.1
    XP_006508268.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_027629.3 → NP_081905.1  glucose 1,6-bisphosphate synthase

      See identical proteins and their annotated locations for NP_081905.1

      Status: VALIDATED

      Source sequence(s)
      AC121815, AC122269, AK016437, BB633030, CF531609, CK379061
      Consensus CDS
      CCDS40035.1
      UniProtKB/Swiss-Prot
      Q8CAA7
      Related
      ENSMUSP00000081998.4, ENSMUST00000084935.11
      Conserved Domains (1) summary
      PTZ00150
      Location:24 → 620
      PTZ00150; phosphoglucomutase-2-like protein; Provisional

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      99876471..99928079
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006508205.3 → XP_006508268.1  glucose 1,6-bisphosphate synthase isoform X1

      See identical proteins and their annotated locations for XP_006508268.1

      UniProtKB/Swiss-Prot
      Q8CAA7
      Conserved Domains (1) summary
      PTZ00150
      Location:24 → 620
      PTZ00150; phosphoglucomutase-2-like protein; Provisional

    2. XM_006508204.3 → XP_006508267.1  glucose 1,6-bisphosphate synthase isoform X1

      See identical proteins and their annotated locations for XP_006508267.1

      UniProtKB/Swiss-Prot
      Q8CAA7
      Conserved Domains (1) summary
      PTZ00150
      Location:24 → 620
      PTZ00150; phosphoglucomutase-2-like protein; Provisional
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8CAA7.1 GenPept UniProtKB/Swiss-Prot:Q8CAA7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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