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    PF3D7_1347100 DNA topoisomerase 3, putative [ Plasmodium falciparum 3D7 ]

    Gene ID: 814216, updated on 17-May-2024

    Summary

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    Gene symbol
    PF3D7_1347100
    Gene description
    DNA topoisomerase 3, putative
    Primary source
    PlasmoDB:PF3D7_1347100
    Locus tag
    PF3D7_1347100
    See related
    VEuPathDB:PF3D7_1347100
    Gene type
    protein coding
    RNA name
    DNA topoisomerase 3, putative
    RefSeq status
    PROVISIONAL
    Organism
    Plasmodium falciparum 3D7 (isolate: 3D7)
    Lineage
    Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida; Plasmodiidae; Plasmodium; Plasmodium (Laverania)
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    Genomic context

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    See PF3D7_1347100 in Genome Data Viewer
    Location:
    chromosome: 13
    Exon count:
    1
    Sequence:
    Chromosome: 13; NC_004331.3 (1886344..1888476)

    Chromosome 13 - NC_004331.3Genomic Context describing neighboring genes Neighboring gene conserved Plasmodium protein, unknown function Neighboring gene WD repeat-containing protein 92, putative Neighboring gene nucleoside transporter 1 Neighboring gene conserved Plasmodium membrane protein, unknown function

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_004331.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Elucidation of an essential function of the unique charged domain of Plasmodium topoisomerase III. Bansod S, et al. Biochem J, 2020 Nov 26. PMID 33241842
    2. Bloom Helicase Along with Recombinase Rad51 Repairs the Mitochondrial Genome of the Malaria Parasite. Jha P, et al. mSphere, 2021 Dec 22. PMID 34730376, Free PMC Article
    3. A Prioritized and Validated Resource of Mitochondrial Proteins in Plasmodium Identifies Unique Biology. van Esveld SL, et al. mSphere, 2021 Oct 27. PMID 34494883, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by GeneDB

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    DNA topoisomerase 3, putative
    XP_001350185.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004331.3 Reference assembly

      Range
      1886344..1888476
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_001350149.1 → XP_001350185.1  DNA topoisomerase 3, putative [Plasmodium falciparum 3D7]

      See identical proteins and their annotated locations for XP_001350185.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A0L1I9H7, A0A0L7KCS6, Q8IDM7, W7F6L4
      Conserved Domains (3) summary
      cd03362
      Location:5 → 163
      TOPRIM_TopoIA_TopoIII; TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving ...
      COG0550
      Location:5 → 691
      TopA; DNA topoisomerase IA [Replication, recombination and repair]
      cd00186
      Location:169 → 683
      TOP1Ac; DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA ...
    Nucleotide Protein
    Heading Accession and Version

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