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    PF3D7_0212600 secreted protein with altered thrombospondin repeat domain [ Plasmodium falciparum 3D7 ]

    Gene ID: 812714, updated on 10-Sep-2023

    Summary

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    Gene symbol
    PF3D7_0212600
    Gene description
    secreted protein with altered thrombospondin repeat domain
    Locus tag
    PF3D7_0212600
    Gene type
    protein coding
    RNA name
    secreted protein with altered thrombospondin repeat domain
    RefSeq status
    PROVISIONAL
    Organism
    Plasmodium falciparum 3D7 (isolate: 3D7)
    Lineage
    Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida; Plasmodiidae; Plasmodium; Plasmodium (Laverania)
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    Genomic context

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    See PF3D7_0212600 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    2
    Sequence:
    Chromosome: 2; NC_037280.1 (522931..523999)

    Chromosome 2 - NC_037280.1Genomic Context describing neighboring genes Neighboring gene conserved Plasmodium membrane protein, unknown function Neighboring gene conserved Plasmodium protein, unknown function Neighboring gene SRR1-like protein Neighboring gene multidrug efflux pump, putative

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037280.1

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A conserved apicomplexan microneme protein contributes to Toxoplasma gondii invasion and virulence. Huynh MH, et al. Infect Immun, 2014 Oct. PMID 25092910, Free PMC Article
    2. PfSPATR, a Plasmodium falciparum protein containing an altered thrombospondin type I repeat domain is expressed at several stages of the parasite life cycle and is the target of inhibitory antibodies. Chattopadhyay R, et al. J Biol Chem, 2003 Jul 11. PMID 12716913
    3. Identification of peptides with high red blood cell and hepatocyte binding activity in the Plasmodium falciparum multi-stage invasion proteins: PfSPATR and MCP-1. Curtidor H, et al. Biochimie, 2008 Nov-Dec. PMID 18832006
    4. Transcriptional profiling of growth perturbations of the human malaria parasite Plasmodium falciparum. Hu G, et al. Nat Biotechnol, 2010 Jan. PMID 20037583
    5. Chromosome 2 sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, et al. Science, 1998 Nov 6. PMID 9804551

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. This work reports the fine mapping of PfSPATR and MCP-1 binding regions to HepG2 cells and human red blood cell (RBCs) as well as their role during merozoite in vitro invasion of RBCs.
      Title: Identification of peptides with high red blood cell and hepatocyte binding activity in the Plasmodium falciparum multi-stage invasion proteins: PfSPATR and MCP-1.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by GeneDB

    Process Evidence Code Pubs
    acts_upstream_of_or_within cell-cell adhesion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in apical part of cell IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in microneme ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    located_in rhoptry IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    secreted protein with altered thrombospondin repeat domain

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_037280.1 Reference assembly

      Range
      522931..523999
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_001349596.1 → XP_001349632.1  secreted protein with altered thrombospondin repeat domain [Plasmodium falciparum 3D7]

      See identical proteins and their annotated locations for XP_001349632.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A024VFE2, A0A024WF48, A0A024XFT0, A0A0L1I5C6, A0A0L7KEL5, A0A0L7LWF3, A0A2I0BVC8, O96207, W4IPM8, W4J856, W7FDH5, W7GCV4, W7K4X3
      Conserved Domains (1) summary
      pfam19028
      Location:199 → 250
      TSP1_spondin; Spondin-like TSP1 domain
    Nucleotide Protein
    Heading Accession and Version

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