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    PF3D7_0808200 plasmepsin X [ Plasmodium falciparum 3D7 ]

    Gene ID: 2655308, updated on 25-Jan-2024

    Summary

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    Gene symbol
    PF3D7_0808200
    Gene description
    plasmepsin X
    Locus tag
    PF3D7_0808200
    Gene type
    protein coding
    RNA name
    plasmepsin X
    RefSeq status
    PROVISIONAL
    Organism
    Plasmodium falciparum 3D7 (isolate: 3D7)
    Lineage
    Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida; Plasmodiidae; Plasmodium; Plasmodium (Laverania)
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    Genomic context

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    Location:
    chromosome: 8
    Exon count:
    1
    Sequence:
    Chromosome: 8; NC_004329.3 (416344..418065, complement)

    Chromosome 8 - NC_004329.3Genomic Context describing neighboring genes Neighboring gene conserved Plasmodium protein, unknown function Neighboring gene AP-3 complex subunit delta, putative Neighboring gene ubiquitin regulatory protein, putative Neighboring gene coatomer subunit epsilon, putative

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_004329.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Maturation and substrate processing topography of the Plasmodium falciparum invasion/egress protease plasmepsin X. Mukherjee S, et al. Nat Commun, 2022 Aug 4. PMID 35927261, Free PMC Article
    2. Dual Plasmepsin-Targeting Antimalarial Agents Disrupt Multiple Stages of the Malaria Parasite Life Cycle. Favuzza P, et al. Cell Host Microbe, 2020 Apr 8. PMID 32109369, Free PMC Article
    3. Plasmepsins IX and X are essential and druggable mediators of malaria parasite egress and invasion. Nasamu AS, et al. Science, 2017 Oct 27. PMID 29074774, Free PMC Article
    4. Transcriptional profiling of growth perturbations of the human malaria parasite Plasmodium falciparum. Hu G, et al. Nat Biotechnol, 2010 Jan. PMID 20037583
    5. A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, et al. Nature, 2005 Nov 3. PMID 16267556

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Maturation and substrate processing topography of the Plasmodium falciparum invasion/egress protease plasmepsin X.
      Title: Maturation and substrate processing topography of the Plasmodium falciparum invasion/egress protease plasmepsin X.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by GeneDB

    Function Evidence Code Pubs
    enables aspartic-type endopeptidase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within exit from host cell IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within proteolysis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within response to xenobiotic stimulus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within symbiont entry into host IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in apical part of cell IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in exoneme IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    plasmepsin X
    XP_001349441.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004329.3 Reference assembly

      Range
      416344..418065 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_001349405.1 → XP_001349441.1  plasmepsin X [Plasmodium falciparum 3D7]

      See identical proteins and their annotated locations for XP_001349441.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      Q8IAS0, W7JWW5
      UniProtKB/TrEMBL
      A0A024VAE1, A0A024VNX8, A0A024WRV3, A0A0L1I9M2, A0A0L7KCR7, A0A8S9VUL1, Q2KNW1, Q2KNX8, W7FEZ5
      Conserved Domains (1) summary
      cd05471
      Location:248 → 568
      pepsin_like; Pepsin-like aspartic proteases, bilobal enzymes that cleave bonds in peptides at acidic pH
    Nucleotide Protein
    Heading Accession and Version

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