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    Bdh2 3-hydroxybutyrate dehydrogenase 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 295458, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Bdh2provided by RGD
    Official Full Name
    3-hydroxybutyrate dehydrogenase 2provided by RGD
    Primary source
    RGD:1309898
    See related
    Ensembl:ENSRNOG00000014490 AllianceGenome:RGD:1309898
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Dhrs6
    Summary
    Predicted to enable 3-hydroxybutyrate dehydrogenase activity; NAD binding activity; and oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor. Predicted to be involved in several processes, including fatty acid beta-oxidation; heme metabolic process; and siderophore biosynthetic process. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Orthologous to human BDH2 (3-hydroxybutyrate dehydrogenase 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Kidney (RPKM 285.2), Heart (RPKM 53.4) and 7 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    2q43
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (226376346..226397010)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (223702410..223723076)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (240461505..240482149)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene myosin light chain 12A, pseudogene 1 Neighboring gene centromere protein E Neighboring gene solute carrier family 9 member B2 Neighboring gene solute carrier family 9 member B1 Neighboring gene uncharacterized LOC134485973

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Characterization of human DHRS6, an orphan short chain dehydrogenase/reductase enzyme: a novel, cytosolic type 2 R-beta-hydroxybutyrate dehydrogenase. Guo K, et al. J Biol Chem, 2006 Apr 14. PMID 16380372
    2. A mammalian siderophore synthesized by an enzyme with a bacterial homolog involved in enterobactin production. Devireddy LR, et al. Cell, 2010 Jun 11. PMID 20550936, Free PMC Article
    3. Analysis of proteomic changes induced upon cellular differentiation of the human intestinal cell line Caco-2. Buhrke T, et al. Dev Growth Differ, 2011 Apr. PMID 21492153
    4. Large-scale proteomics and phosphoproteomics of urinary exosomes. Gonzales PA, et al. J Am Soc Nephrol, 2009 Feb. PMID 19056867, Free PMC Article
    5. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Principe S, et al. Proteomics, 2013 May. PMID 23533145, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 3-hydroxybutyrate dehydrogenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 3-hydroxybutyrate dehydrogenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 3-hydroxybutyrate dehydrogenase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables 4-oxoproline reductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables NAD binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables NAD binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in epithelial cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in epithelial cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in fatty acid beta-oxidation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in fatty acid beta-oxidation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in heme metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_positive_effect intracellular sequestering of iron ion ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_positive_effect intracellular sequestering of iron ion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in siderophore biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in siderophore biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in siderophore biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    dehydrogenase/reductase SDR family member 6
    Names
    (R)-beta-hydroxybutyrate dehydrogenase
    3-hydroxybutyrate dehydrogenase, type 2
    4-oxo-L-proline reductase
    R-beta-hydroxybutyrate dehydrogenase
    dehydrogenase/reductase (SDR family) member 6
    oxidoreductase UCPA
    short chain dehydrogenase/reductase family 15C member 1
    NP_001099943.1
    XP_006233384.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106473.1 → NP_001099943.1  dehydrogenase/reductase SDR family member 6

      See identical proteins and their annotated locations for NP_001099943.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473952
      UniProtKB/TrEMBL
      A0A0A0MXX5
      Related
      ENSRNOP00000019507.4, ENSRNOT00000019507.6
      Conserved Domains (2) summary
      cd05368
      Location:15 → 255
      DHRS6_like_SDR_c; human DHRS6-like, classical (c) SDRs
      PRK06138
      Location:12 → 254
      PRK06138; short chain dehydrogenase; Provisional

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      226376346..226397010
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006233322.5 → XP_006233384.1  dehydrogenase/reductase SDR family member 6 isoform X1

      See identical proteins and their annotated locations for XP_006233384.1

      UniProtKB/Swiss-Prot
      D4A1J4
      UniProtKB/TrEMBL
      A6HVW3
      Conserved Domains (2) summary
      cd05368
      Location:5 → 245
      DHRS6_like_SDR_c; human DHRS6-like, classical (c) SDRs
      PRK06138
      Location:2 → 244
      PRK06138; short chain dehydrogenase; Provisional

    RNA

    1. XR_010063596.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    D4A1J4.2 GenPept UniProtKB/Swiss-Prot:D4A1J4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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