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    Cox8a cytochrome c oxidase subunit 8A [ Rattus norvegicus (Norway rat) ]

    Gene ID: 171335, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Cox8aprovided by RGD
    Official Full Name
    cytochrome c oxidase subunit 8Aprovided by RGD
    Primary source
    RGD:620638
    See related
    AllianceGenome:RGD:620638
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable cytochrome-c oxidase activity. Predicted to be involved in mitochondrial electron transport, cytochrome c to oxygen and proton transmembrane transport. Predicted to be integral component of membrane. Predicted to be part of respiratory chain complex IV. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in cytochrome-c oxidase deficiency disease. Orthologous to human COX8A (cytochrome c oxidase subunit 8A). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Kidney (RPKM 1825.4), Brain (RPKM 705.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    1q43
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (213831302..213833623, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (204402118..204404439, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (222466575..222468896, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene mono-ADP ribosylhydrolase 1 Neighboring gene uncharacterized LOC108349688 Neighboring gene OTU deubiquitinase, ubiquitin aldehyde binding 1 Neighboring gene heterogeneous nuclear ribonucleoprotein R, pseudogene 2 Neighboring gene N(alpha)-acetyltransferase 40, NatD catalytic subunit Neighboring gene REST corepressor 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Complexity of nucleus-encoded genes of mammalian cytochrome c oxidase. Cao XN, et al. Ann N Y Acad Sci, 1988. PMID 2854406
    2. Molecular cloning and further characterization of cDNAs for rat nuclear-encoded cytochrome c oxidase subunits VIc and VIII. Suske G, et al. Eur J Biochem, 1987 Oct 1. PMID 2822403
    3. [Malignant breast tumors in the population of the province of Varese from 01/01/76 to 12/31/87]. Crosignani P. Pathologica, 1992 Nov-Dec. PMID 1300526
    4. Tissue-specific regulation of cytochrome c oxidase subunit expression by thyroid hormone. Sheehan TE, et al. Am J Physiol Endocrinol Metab, 2004 Jun. PMID 14970006
    5. A third isoform of cytochrome c oxidase subunit VIII is present in mammals. Hüttemann M, et al. Gene, 2003 Jul 17. PMID 12909344

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables cytochrome-c oxidase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mitochondrial electron transport, cytochrome c to oxygen IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of mitochondrial respiratory chain complex IV ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of mitochondrial respiratory chain complex IV TAS
    Traceable Author Statement
    more info
    		 PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of respiratory chain complex IV IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    cytochrome c oxidase subunit 8A, mitochondrial
    Names
    cytochrome c oxidase polypeptide VIII-liver
    cytochrome c oxidase subunit 8-2
    cytochrome c oxidase subunit VIIIa
    NP_599172.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_134345.1 → NP_599172.1  cytochrome c oxidase subunit 8A, mitochondrial precursor

      See identical proteins and their annotated locations for NP_599172.1

      Status: VALIDATED

      Source sequence(s)
      CB701133, L48209
      UniProtKB/Swiss-Prot
      A0JMZ9, P80433
      UniProtKB/TrEMBL
      A6HZN8
      Conserved Domains (1) summary
      pfam02285
      Location:27 → 67
      COX8; Cytochrome oxidase c subunit VIII

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      213831302..213833623 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P80433.3 GenPept UniProtKB/Swiss-Prot:P80433

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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