Kcnmb1 potassium calcium-activated channel subfamily M regulatory beta subunit 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Kcnmb1provided by RGD
Official Full Name: potassium calcium-activated channel subfamily M regulatory beta subunit 1provided by RGD
Primary source: RGD:2961
See related: Ensembl:ENSRNOG00000005465 AllianceGenome:RGD:2961
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: BKbeta; BKbeta1; slo-beta; slo-beta-1; k(VCA)beta-1
Summary: Enables potassium channel regulator activity. Involved in several processes, including cellular response to bile acid; cellular response to ethanol; and cellular response to hypoxia. Predicted to be integral component of membrane. Predicted to be part of voltage-gated potassium channel complex. Used to study hypertension. Biomarker of hypertension and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in hypertension. Orthologous to human KCNMB1 (potassium calcium-activated channel subfamily M regulatory beta subunit 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Uterus (RPKM 45.2), Kidney (RPKM 10.4) and 5 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q12

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (19062014..19119005)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (18557510..18614824)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (18910586..18922856)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interspecies and regional variability of alcohol action on large cerebral arteries: regulation by KCNMB1 proteins.
Title: Interspecies and regional variability of alcohol action on large cerebral arteries: regulation by KCNMB1 proteins.
Cholesterol activates BK channels by increasing KCNMB1 protein levels in the plasmalemma.
Title: Cholesterol activates BK channels by increasing KCNMB1 protein levels in the plasmalemma.
Aging influences cerebrovascular myogenic reactivity and BK channel function in a sex-specific manner.
Title: Aging influences cerebrovascular myogenic reactivity and BK channel function in a sex-specific manner.
Antenatal Dexamethasone Exposure Impairs the High-Conductance Ca(2+)-Activated K(+) Channels via Epigenetic Alteration at Gene Promoter in Male Offspring.
Title: Antenatal Dexamethasone Exposure Impairs the High-Conductance Ca(2+)-Activated K(+) Channels via Epigenetic Alteration at Gene Promoter in Male Offspring.
Data show that potassium channel subfamily M regulatory beta subunit 1 (beta1 Subunit) surface trafficking is Impaired in cerebral arteries of stroke-prone spontaneously hypertensive rats (SP-SHRs).
Title: Impaired Trafficking of β1 Subunits Inhibits BK Channels in Cerebral Arteries of Hypertensive Rats.
hypertension and aging exert opposing effects on DNA methylation at BKbeta1 promoter, subsequently resulting in different beta1 expression
Title: BK(Ca) channel activity and vascular contractility alterations with hypertension and aging via β1 subunit promoter methylation in mesenteric arteries.
Study showed that in human and rat arterial myocytes, membrane depolarization rapidly increased the cell surface abundance of auxiliary BK beta1 subunits but not that of the pore-forming BKalpha channels. Membrane depolarization stimulated voltage-dependent Ca(2+) channels, leading to Ca(2+) influx and the activation of Rho kinase (ROCK) 1 and 2.
Title: Membrane depolarization activates BK channels through ROCK-mediated β1 subunit surface trafficking to limit vasoconstriction.
n-3 PUFAs protect the coronary BK channel function and coronary vasoreactivity in diabetic rats as a result of not only increasing BK-beta1 protein expressions, but also decreasing coronary artery tension and coronary smooth muscle cytosolic Ca2+ concentrations.
Title: Regulation of Coronary Arterial Large Conductance Ca2+-Activated K+ Channel Protein Expression and Function by n-3 Polyunsaturated Fatty Acids in Diabetic Rats.
Data show that leukotriene B4, but not other leukotrienes of the LT4 family, activates recombinant (cbv1-beta1) Lrge-conductance calcium-activated potassium (BK) channels.
Title: Activation of calcium- and voltage-gated potassium channels of large conductance by leukotriene B4.
aging decreases capability of MaxiK channel in regulating vascular tone in the MA, which may be partially mediated by unparallel downregulation of alpha- and beta1-subunit expression
Title: Aging decreases the contribution of MaxiK channel in regulating vascular tone in mesenteric artery by unparallel downregulation of α- and β1-subunit expression.

Submit: New GeneRIF Correction See all GeneRIFs (24)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables calcium-activated potassium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables calcium-activated potassium channel activity	ISO Inferred from Sequence Orthology more info
enables potassium channel regulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables potassium channel regulator activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in cellular response to bile acid	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to ethanol	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to hypoxia	IEP Inferred from Expression Pattern more info	PubMed
involved_in detection of calcium ion	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of potassium ion transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within potassium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in response to calcium ion	IDA Inferred from Direct Assay more info	PubMed
involved_in vasodilation	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	TAS Traceable Author Statement more info
part_of voltage-gated potassium channel complex	IBA Inferred from Biological aspect of Ancestor more info
part_of voltage-gated potassium channel complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: calcium-activated potassium channel subunit beta-1

Names: BK channel subunit beta-1; calcium-activated potassium channel beta subunit; calcium-activated potassium channel subunit beta; calcium-activated potassium channel, subfamily M subunit beta-1; charybdotoxin receptor subunit beta-1; maxi K channel subunit beta-1; potassium channel subfamily M regulatory beta subunit 1; potassium large conductance calcium-activated channel, subfamily M, beta member 1; slowpoke-beta

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_019273.1 → NP_062146.1 calcium-activated potassium channel subunit beta-1

See identical proteins and their annotated locations for NP_062146.1

Status: PROVISIONAL

Source sequence(s)

AF020712

UniProtKB/Swiss-Prot

O35337, O88805, P97678, Q9ESK7, Q9QWI7

UniProtKB/TrEMBL

A6HDH5, B5U130

Related

ENSRNOP00000007408.3, ENSRNOT00000007408.7

Conserved Domains (1) summary

pfam03185
Location:7 → 190

CaKB; Calcium-activated potassium channel, beta subunit

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

19062014..19119005

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039085796.2 → XP_038941724.1 calcium-activated potassium channel subunit beta-1 isoform X2

Conserved Domains (1) summary

pfam03185
Location:7 → 102

CaKB; Calcium-activated potassium channel, beta subunit
XM_039085797.2 → XP_038941725.1 calcium-activated potassium channel subunit beta-1 isoform X3

UniProtKB/TrEMBL

A6HDH4

Related

ENSRNOP00000071161.2

Conserved Domains (1) summary

pfam03185
Location:7 → 126

CaKB; Calcium-activated potassium channel, beta subunit
XM_006246089.5 → XP_006246151.1 calcium-activated potassium channel subunit beta-1 isoform X1

See identical proteins and their annotated locations for XP_006246151.1

UniProtKB/Swiss-Prot

O35337, O88805, P97678, Q9ESK7, Q9QWI7

UniProtKB/TrEMBL

A6HDH5, B5U130

Conserved Domains (1) summary

pfam03185
Location:7 → 190

CaKB; Calcium-activated potassium channel, beta subunit
XM_063268844.1 → XP_063124914.1 calcium-activated potassium channel subunit beta-1 isoform X3

UniProtKB/TrEMBL

A6HDH4