Ilkap ILK associated serine/threonine phosphatase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ilkapprovided by RGD
Official Full Name: ILK associated serine/threonine phosphataseprovided by RGD
Primary source: RGD:620128
See related: Ensembl:ENSRNOG00000020115 AllianceGenome:RGD:620128
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables protein serine/threonine phosphatase activity. Involved in protein dephosphorylation and regulation of nuclear cell cycle DNA replication. Predicted to be located in nucleoplasm. Predicted to be active in cytosol and nucleus. Orthologous to human ILKAP (ILK associated serine/threonine phosphatase). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Thymus (RPKM 121.1), Adrenal (RPKM 104.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 9q36

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	9	NC_086027.1 (99413981..99436262, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	9	NC_051344.1 (91966440..91988791, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	9	NC_005108.4 (98514599..98536586, complement)

Chromosome 9 - NC_086027.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

distinct functions for mGluR2 and mGluR3 and dynamic regulation of mGluR3 by PP2C
Title: Protein phosphatase 2C binds selectively to and dephosphorylates metabotropic glutamate receptor 3.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables myosin phosphatase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine phosphatase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in protein dephosphorylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of nuclear cell cycle DNA replication	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: integrin-linked kinase-associated serine/threonine phosphatase 2C

Names: PP2Cdelta; protein phosphatase 2C

NP_072128.2

EC 3.1.3.16

XP_038940097.1

EC 3.1.3.16

XP_038940098.1

EC 3.1.3.16

XP_063123756.1

EC 3.1.3.16

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_022606.2 → NP_072128.2 integrin-linked kinase-associated serine/threonine phosphatase 2C

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000009

UniProtKB/Swiss-Prot

Q6P6U8, Q9Z1Z6

UniProtKB/TrEMBL

A0A0G2JSS1, A6JQR2

Related

ENSRNOP00000027295.4, ENSRNOT00000027295.6

Conserved Domains (1) summary

cd00143
Location:108 → 390

PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086027.1 Reference GRCr8

Range

99413981..99436262 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039084170.2 → XP_038940098.1 integrin-linked kinase-associated serine/threonine phosphatase 2C isoform X2

UniProtKB/TrEMBL

A6JQR3

Conserved Domains (1) summary

cd00143
Location:1 → 270

PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
XM_039084169.2 → XP_038940097.1 integrin-linked kinase-associated serine/threonine phosphatase 2C isoform X2

UniProtKB/TrEMBL

A6JQR3

Conserved Domains (1) summary

cd00143
Location:1 → 270

PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
XM_063267686.1 → XP_063123756.1 integrin-linked kinase-associated serine/threonine phosphatase 2C isoform X1

UniProtKB/TrEMBL

A0A8I6GBB0