Kcnd3 potassium voltage-gated channel subfamily D member 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Kcnd3provided by RGD
Official Full Name: potassium voltage-gated channel subfamily D member 3provided by RGD
Primary source: RGD:68394
See related: Ensembl:ENSRNOG00000014686 AllianceGenome:RGD:68394
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Kv4.3
Summary: Enables voltage-gated potassium channel activity. Contributes to A-type (transient outward) potassium channel activity. Involved in cellular response to BMP stimulus; potassium ion export across plasma membrane; and potassium ion import across plasma membrane. Located in several cellular components, including caveola; neuronal cell body; and perinuclear endoplasmic reticulum. Is integral component of plasma membrane. Part of voltage-gated potassium channel complex. Human ortholog(s) of this gene implicated in Brugada syndrome 9 and spinocerebellar ataxia type 19/22. Orthologous to human KCND3 (potassium voltage-gated channel subfamily D member 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Brain (RPKM 79.7), Uterus (RPKM 58.5) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q34

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (195626316..195843690)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (192937950..193155345)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (207923775..208140727)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Kv4.3 Channel Dysfunction Contributes to Trigeminal Neuropathic Pain Manifested with Orofacial Cold Hypersensitivity in Rats.
Title: Kv4.3 Channel Dysfunction Contributes to Trigeminal Neuropathic Pain Manifested with Orofacial Cold Hypersensitivity in Rats.
Over-expression of Kv4.3 gene reverses cardiac remodeling and transient-outward K(+) current (Ito) reduction via CaMKII inhibition in myocardial infarction.
Title: Over-expression of Kv4.3 gene reverses cardiac remodeling and transient-outward K(+) current (Ito) reduction via CaMKII inhibition in myocardial infarction.
Immunogold staining and electron microscopy of heart vibrosections was performed to localize Kv4.2/Kv4.3 and Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) proteins. Patch-Clamp recordings in control conditions and after lipid raft or caveolae disruption show that the CaMKII-Kv4 channel complex must associate in non-caveolar lipid rafts to be functional.
Title: CaMKII Modulates the Cardiac Transient Outward K(+) Current through its Association with Kv4 Channels in Non-Caveolar Membrane Rafts.
Kv4.3 reduction is an important mediator in cardiac hypertrophy development via excessive CaMKII activation.
Title: Kv4.3 expression abrogates and reverses norepinephrine-induced myocyte hypertrophy by CaMKII inhibition.
down-regulation of Kv4.3 channels mediating A-type K(+) (IA) currents currents in nociceptive V2 trigeminal neurons is an underlying mechanism of oxaliplatin-induced orofacial neuropathic pain.
Title: Down-regulation of Kv4.3 channels and a-type K(+) currents in V2 trigeminal ganglion neurons of rats following oxaliplatin treatment.
NMDA reduced both currents in a concentration-dependent manner, whereas there was no significant impact on the currents when perfused with MK-801. MDD rats exhibited significantly more fibrosis areas in heart tissue and reduced expression of Kv4.2, Kv4.3, and Cav1.2.
Title: The activation of N-methyl-d-aspartate receptors downregulates transient outward potassium and L-type calcium currents in rat models of depression.
This study demonstated that that Kv4.3 is involved in vibration-induced muscle pain and explored whether changes in Kv4.3 expression in nociceptors contributes to the mechanical hyperalgesia in a model of hand-arm vibration syndrome in the rat.
Title: Role of Kv4.3 in Vibration-Induced Muscle Pain in the Rat.
KChIP1 plays a neuroprotective role against 4-AP acute induced cell death in primary hippocampal cells through regulation of Kv 4.3 and GABA transmission but this is lost after long term exposure.
Title: Neuroprotective or neurotoxic effects of 4-aminopyridine mediated by KChIP1 regulation through adjustment of Kv 4.3 potassium channels expression and GABA-mediated transmission in primary hippocampal cells.
These results indicate that Kv4.3 is likely the target of discrepin and highlight the importance of the basic residue K13, located in the alpha-helix of the toxin, for current blockage.
Title: Interaction of the scorpion toxin discrepin with Kv4.3 channels and A-type K(+) channels in cerebellum granular cells.
This study demonistrared that the expression and function of Kv4.3 channels in neurons of the rat bed nucleus of the stria terminalis.
Title: Distribution and functional expression of Kv4 family α subunits and associated KChIP β subunits in the bed nucleus of the stria terminalis.

Submit: New GeneRIF Correction See all GeneRIFs (34)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D2Got136 (e-PCR)
- UniSTS:114497

D2Rat52 (e-PCR)
- UniSTS:118704

D2Cebr1 (e-PCR)
- UniSTS:518881

RH140120 (e-PCR)
- UniSTS:222199

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables A-type (transient outward) potassium channel activity	IBA Inferred from Biological aspect of Ancestor more info
contributes_to A-type (transient outward) potassium channel activity	IDA Inferred from Direct Assay more info	PubMed
enables A-type (transient outward) potassium channel activity	IEA Inferred from Electronic Annotation more info
enables A-type (transient outward) potassium channel activity	IMP Inferred from Mutant Phenotype more info	PubMed
contributes_to A-type (transient outward) potassium channel activity	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables monoatomic ion channel activity	IDA Inferred from Direct Assay more info	PubMed
enables potassium channel activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transmembrane transporter binding	IEA Inferred from Electronic Annotation more info
enables transmembrane transporter binding	ISO Inferred from Sequence Orthology more info
enables voltage-gated potassium channel activity	IDA Inferred from Direct Assay more info	PubMed
enables voltage-gated potassium channel activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization	ISO Inferred from Sequence Orthology more info
enables voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization	IEA Inferred from Electronic Annotation more info
contributes_to voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in action potential	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cardiac muscle cell action potential involved in contraction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell communication involved in cardiac conduction	ISO Inferred from Sequence Orthology more info
involved_in cellular response to BMP stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within establishment of localization in cell	ISO Inferred from Sequence Orthology more info
involved_in membrane repolarization	ISO Inferred from Sequence Orthology more info
involved_in membrane repolarization during ventricular cardiac muscle cell action potential	IEA Inferred from Electronic Annotation more info
involved_in potassium ion export across plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in potassium ion export across plasma membrane	IDA Inferred from Direct Assay more info	PubMed
involved_in potassium ion export across plasma membrane	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within potassium ion export across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in potassium ion export across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in potassium ion import across plasma membrane	IDA Inferred from Direct Assay more info	PubMed
involved_in potassium ion transport	TAS Traceable Author Statement more info	PubMed
involved_in protein homooligomerization	IEA Inferred from Electronic Annotation more info
involved_in regulation of heart rate by cardiac conduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of heart rate by cardiac conduction	ISO Inferred from Sequence Orthology more info
involved_in regulation of heart rate by cardiac conduction	ISO Inferred from Sequence Orthology more info
involved_in ventricular cardiac muscle cell membrane repolarization	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in GABA-ergic synapse	IEA Inferred from Electronic Annotation more info
is_active_in GABA-ergic synapse	ISO Inferred from Sequence Orthology more info
located_in caveola	IDA Inferred from Direct Assay more info	PubMed
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
is_active_in dendritic spine	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	ISO Inferred from Sequence Orthology more info
is_active_in neuronal cell body	IBA Inferred from Biological aspect of Ancestor more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in perinuclear endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in postsynaptic specialization membrane	IEA Inferred from Electronic Annotation more info
is_active_in postsynaptic specialization membrane	ISO Inferred from Sequence Orthology more info
part_of potassium channel complex	IDA Inferred from Direct Assay more info	PubMed
located_in sarcolemma	IEA Inferred from Electronic Annotation more info
part_of voltage-gated potassium channel complex	IBA Inferred from Biological aspect of Ancestor more info
part_of voltage-gated potassium channel complex	IDA Inferred from Direct Assay more info	PubMed
part_of voltage-gated potassium channel complex	IEA Inferred from Electronic Annotation more info
part_of voltage-gated potassium channel complex	IPI Inferred from Physical Interaction more info	PubMed
part_of voltage-gated potassium channel complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: potassium voltage-gated channel subfamily D member 3

Names: potassium channel, voltage-gated Shal-related subfamily D, member 3; potassium voltage gated channel, Shal-related family, member 3; potassium voltage-gated channel, Shal-related subfamily, member 3; voltage-gated potassium channel subunit Kv4.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001270962.1 → NP_001257891.1 potassium voltage-gated channel subfamily D member 3 isoform 1

See identical proteins and their annotated locations for NP_001257891.1

Status: VALIDATED

Description

Transcript Variant: This variant (1, also known as Kv4.3L and Kv4.3c) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

JAXUCZ010000002

UniProtKB/Swiss-Prot

O08723, P70622, Q62897, Q63286, Q99P42

UniProtKB/TrEMBL

A0A0G2JSN5

Related

ENSRNOP00000019997.4, ENSRNOT00000019997.7

Conserved Domains (6) summary

smart00225
Location:42 → 139

BTB; Broad-Complex, Tramtrack and Bric a brac

pfam00520
Location:217 → 412

Ion_trans; Ion transport protein

pfam02214
Location:42 → 131

BTB_2; BTB/POZ domain

pfam07885
Location:328 → 408

Ion_trans_2; Ion channel

pfam11601
Location:3 → 28

Shal-type; Shal-type voltage-gated potassium channels

pfam11879
Location:442 → 563

DUF3399; Domain of unknown function (DUF3399)
NM_001270963.1 → NP_001257892.1 potassium voltage-gated channel subfamily D member 3 isoform 2

See identical proteins and their annotated locations for NP_001257892.1

Status: VALIDATED

Description

Transcript Variant: This variant (2, also known as Kv4.3M and Kv4.3a) lacks an in-frame exon in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.

Source sequence(s)

JAXUCZ010000002

UniProtKB/Swiss-Prot

O08723, P70622, Q62897, Q63286, Q99P42

UniProtKB/TrEMBL

A0A0G2JSW5

Related

ENSRNOP00000049111.2, ENSRNOT00000051835.5

Conserved Domains (6) summary

smart00225
Location:42 → 139

BTB; Broad-Complex, Tramtrack and Bric a brac

pfam00520
Location:217 → 412

Ion_trans; Ion transport protein

pfam02214
Location:42 → 131

BTB_2; BTB/POZ domain

pfam07885
Location:328 → 408

Ion_trans_2; Ion channel

pfam11601
Location:3 → 28

Shal-type; Shal-type voltage-gated potassium channels

pfam11879
Location:442 → 544

DUF3399; Domain of unknown function (DUF3399)
NM_031739.3 → NP_113927.2 potassium voltage-gated channel subfamily D member 3 isoform 3

Status: VALIDATED

Description

Transcript Variant: This variant (3, also known as Kv4.3S and Kv4.3b) lacks an in-frame exon in the 3' coding region, and lacks a segment in the 3' coding region, which results in a frameshift compared to variant 1. The encoded isoform (3) is shorter and has a distinct C-terminus, compared to isoform 1.

Source sequence(s)

JAXUCZ010000002

UniProtKB/Swiss-Prot

O08723, P70622, Q62897, Q63286, Q99P42

Conserved Domains (6) summary

smart00225
Location:42 → 139

BTB; Broad-Complex, Tramtrack and Bric a brac

pfam00520
Location:217 → 412

Ion_trans; Ion transport protein

pfam02214
Location:42 → 131

BTB_2; BTB/POZ domain

pfam07885
Location:328 → 408

Ion_trans_2; Ion channel

pfam11601
Location:3 → 28

Shal-type; Shal-type voltage-gated potassium channels

pfam11879
Location:442 → 544

DUF3399; Domain of unknown function (DUF3399)