Mep1b meprin A subunit beta [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Mep1bprovided by RGD
Full Name: meprin A subunit betaprovided by RGD
Primary source: RGD:3081
See related: Ensembl:ENSRNOG00000049345 AllianceGenome:RGD:3081
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables metalloendopeptidase activity. Predicted to be involved in inflammatory response. Predicted to act upstream of or within toxin transport. Predicted to be located in membrane. Predicted to be integral component of plasma membrane. Predicted to be part of meprin A complex. Orthologous to human MEP1B (meprin A subunit beta). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward (RPKM 613.6) See more
Orthologs: human mouse all
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Genomic context

Location:: 18p12

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	18	NC_086036.1 (12641041..12667759)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	18	NC_051353.1 (12366126..12392840)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	18	NC_005117.4 (15063159..15090877, complement)

Chromosome 18 - NC_086036.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

identifies proIL-18 as a biologically important substrate for meprin beta and implicates meprins in the modulation of inflammation
Title: Prointerleukin-18 is activated by meprin beta in vitro and in vivo in intestinal inflammation.
In anti-Thy 1.1 glomerulonephritis we observed striking redistribution of meprin beta in tubular epithelial cells from the apical to the basolateral side and the cytosol. This might point to an involvement of meprin beta in this form of glomerulonephritis
Title: Metalloprotease meprin beta in rat kidney: glomerular localization and differential expression in glomerulonephritis.
optimization of activity by pH and NaCl concentration and relevance to catalytic mechanism
Title: Probing the active sites and mechanisms of rat metalloproteases meprin A and B.
A model of the meprin B dimer structure is proposed that provides insight into the relationship between structure and function of this isoform.
Title: Intersubunit and domain interactions of the meprin B metalloproteinase. Disulfide bonds and protein-protein interactions in the MAM and TRAF domains.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables metalloendopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables metalloendopeptidase activity	IDA Inferred from Direct Assay more info	PubMed
enables metalloendopeptidase activity	IEA Inferred from Electronic Annotation more info
enables protein domain specific binding	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info
involved_in proteolysis	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	ISO Inferred from Sequence Orthology more info
part_of meprin A complex	IEA Inferred from Electronic Annotation more info
part_of meprin A complex	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: meprin A subunit beta

Names: endopeptidase-2; meprin 1 beta; meprin A beta; meprin B

NP_037315.1

EC 3.4.24.63

XP_063133193.1

EC 3.4.24.63

XP_063133194.1

EC 3.4.24.63

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_013183.2 → NP_037315.1 meprin A subunit beta precursor

See identical proteins and their annotated locations for NP_037315.1

Status: PROVISIONAL

Source sequence(s)

M88601

UniProtKB/Swiss-Prot

P28826, Q642D0

Related

ENSRNOP00000091050.1, ENSRNOT00000118375.1

Conserved Domains (6) summary

cd06263
Location:266 → 428

MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...

cd00054
Location:609 → 647

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

pfam00629
Location:266 → 430

MAM; MAM domain, meprin/A5/mu

pfam01400
Location:70 → 258

Astacin; Astacin (Peptidase family M12A)

cl00064
Location:30 → 256

ZnMc; Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which ...

cl02446
Location:428 → 586

MATH; MATH (meprin and TRAF-C homology) domain; an independent folding unit with an eight-stranded beta-sandwich structure found in meprins, TRAFs and other proteins. Meprins comprise a class of extracellular metalloproteases which are anchored to the membrane ...