mt-Cytb cytochrome b, mitochondrial [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: mt-Cytbprovided by RGD
Official Full Name: cytochrome b, mitochondrialprovided by RGD
Primary source: RGD:620081
See related: AllianceGenome:RGD:620081
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus (strain: BN/SsNHsdMCW)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: CYTB
Summary: Predicted to enable ubiquinol-cytochrome-c reductase activity. Involved in several processes, including electron transport coupled proton transport; response to cobalamin; and response to glucagon. Located in mitochondrial inner membrane. Is integral component of mitochondrial inner membrane. Part of protein-containing complex. Biomarker of thyrotoxicosis; type 2 diabetes mellitus; and visual epilepsy. Human ortholog(s) of this gene implicated in ovarian carcinoma and urinary bladder cancer. Orthologous to human MT-CYB (mitochondrially encoded cytochrome b). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

Annotation release	Status	Assembly	Chr	Location
RS_2023_06	latest, but not current	mRatBN7.2 (GCF_015227675.2)	MT (non-nuclear)	NC_001665.2 (14136..15278)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	MT (non-nuclear)	NC_001665.2 (14136..15278)

Chromosome MT - NC_001665.2 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Hepcidin or enterocyte iron levels may be involved in the regulation of the age-dependent expression in the duodenum.
Title: Age-dependent expression of duodenal cytochrome b, divalent metal transporter 1, ferroportin 1, and hephaestin in the duodenum of rats.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein-containing complex binding	IPI Inferred from Physical Interaction more info	PubMed
contributes_to ubiquinol-cytochrome-c reductase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquinol-cytochrome-c reductase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in animal organ regeneration	IEP Inferred from Expression Pattern more info	PubMed
involved_in electron transport coupled proton transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitochondrial electron transport, ubiquinol to cytochrome c	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrial electron transport, ubiquinol to cytochrome c	ISO Inferred from Sequence Orthology more info
involved_in response to cadmium ion	IDA Inferred from Direct Assay more info	PubMed
involved_in response to calcium ion	IDA Inferred from Direct Assay more info	PubMed
involved_in response to cobalamin	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to copper ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to ethanol	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to glucagon	IDA Inferred from Direct Assay more info	PubMed
involved_in response to hormone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to hyperoxia	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to hypoxia	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to mercury ion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to nutrient	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to organic cyclic compound	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to organonitrogen compound	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to toxic substance	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrial inner membrane	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial inner membrane	ISO Inferred from Sequence Orthology more info
part_of mitochondrial respiratory chain complex III	IBA Inferred from Biological aspect of Ancestor more info
part_of mitochondrial respiratory chain complex III	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed