Ppard peroxisome proliferator-activated receptor delta [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ppardprovided by RGD
Official Full Name: peroxisome proliferator-activated receptor deltaprovided by RGD
Primary source: RGD:3370
See related: Ensembl:ENSRNOG00000000503 AllianceGenome:RGD:3370
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Pparb
Summary: Enables NF-kappaB binding activity and fatty acid binding activity. Involved in several processes, including decidualization; negative regulation of collagen biosynthetic process; and positive regulation of insulin secretion involved in cellular response to glucose stimulus. Located in nucleus. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human PPARD (peroxisome proliferator activated receptor delta). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Heart (RPKM 30.7), Adrenal (RPKM 23.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 20p12

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	20	NC_086038.1 (6300527..6365707)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	20	NC_051355.1 (6298785..6363970)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	20	NC_005119.4 (7818289..7883482)

Chromosome 20 - NC_086038.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Effects of Exercise Training on PPARbeta/delta Expression in Skeletal Muscle of Rats with Spontaneous Hypertension.
Title: Effects of Exercise Training on PPARβ/δ Expression in Skeletal Muscle of Rats with Spontaneous Hypertension.
miR-24-3p obstructs the proliferation and migration of human skin fibroblasts after thermal injury by targeting PPAR-beta and positively regulated by NF-kappaB.
Title: miR-24-3p obstructs the proliferation and migration of human skin fibroblasts after thermal injury by targeting PPAR-β and positively regulated by NF-κB.
PPARbeta/delta accelerates bone regeneration in diabetic mellitus by enhancing AMPK/mTOR pathway-mediated autophagy.
Title: PPARβ/δ accelerates bone regeneration in diabetic mellitus by enhancing AMPK/mTOR pathway-mediated autophagy.
Peroxisome proliferatoractivated receptor beta/delta regulates cerebral vasospasm after subarachnoid hemorrhage via modulating vascular smooth muscle cells phenotypic conversion.
Title: Peroxisome proliferator‑activated receptor β/δ regulates cerebral vasospasm after subarachnoid hemorrhage via modulating vascular smooth muscle cells phenotypic conversion.
Cardioprotective Effects of PPARbeta/delta Activation against Ischemia/Reperfusion Injury in Rat Heart Are Associated with ALDH2 Upregulation, Amelioration of Oxidative Stress and Preservation of Mitochondrial Energy Production.
Title: Cardioprotective Effects of PPARβ/δ Activation against Ischemia/Reperfusion Injury in Rat Heart Are Associated with ALDH2 Upregulation, Amelioration of Oxidative Stress and Preservation of Mitochondrial Energy Production.
Pharmacological Blockade of PPAR Isoforms Increases Conditioned Fear Responding in the Presence of Nociceptive Tone.
Title: Pharmacological Blockade of PPAR Isoforms Increases Conditioned Fear Responding in the Presence of Nociceptive Tone.
Under high glucose conditions in NRK-52E cells, PPARbeta expression decreased by 33.72% compared with normal glucose. Bezafibrate treatment significantly elevated its expression by 87.72% which was significantly blocked by HET0016.
Title: Effects of PPARs/20-HETE on the renal impairment under diabetic conditions.
PPARdelta-modulated downregulation of TSP-1 is associated with reduced cellular oxidative stress, thereby inhibiting H2O2-induced pheno-typic changes in vascular cells.
Title: Ligand-Activated Peroxisome Proliferator-Activated Receptor δ Attenuates Vascular Oxidative Stress by Inhibiting Thrombospondin-1 Expression.
In vitro, carbacyclin induced proliferation of neonatal and adult mononuclear rat cardiomyocytes via a peroxisome proliferator-activated receptor delta (PPARdelta)/PDK1/p308Akt/GSK3beta/beta-catenin pathway.
Title: Live cell screening platform identifies PPARδ as a regulator of cardiomyocyte proliferation and cardiac repair.
PPARdelta plays an important role in the regulation of serotonin transporter expression
Title: Changes in PPARδ expression in a rat model of stress-induced depression.

Submit: New GeneRIF Correction See all GeneRIFs (69)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

MARC_45796-45797:1102976080:1 (e-PCR)
- UniSTS:471629

MARC_45800-45801:1102973340:2 (e-PCR)
- UniSTS:471631

BE119633 (e-PCR)
- UniSTS:249234

RH134478 (e-PCR)
- UniSTS:217758

UniSTS:496033 (e-PCR)
- UniSTS:496033

Ppard (e-PCR), detects polymorphism
- UniSTS:496033

PMC137182P9 (e-PCR)
- UniSTS:270830

RH94815 (e-PCR)
- UniSTS:120061

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA binding	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity	TAS Traceable Author Statement more info	PubMed
enables DNA-binding transcription factor binding	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables NF-kappaB binding	IPI Inferred from Physical Interaction more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables fatty acid binding	IDA Inferred from Direct Assay more info	PubMed
enables linoleic acid binding	ISO Inferred from Sequence Orthology more info
enables lipid binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nuclear receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables nuclear receptor activity	ISO Inferred from Sequence Orthology more info
enables nuclear receptor activity	TAS Traceable Author Statement more info	PubMed
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info
enables transcription coactivator binding	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within adipose tissue development	ISO Inferred from Sequence Orthology more info
involved_in apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within axon ensheathment	ISO Inferred from Sequence Orthology more info
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of cell population proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell-substrate adhesion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular response to hypoxia	ISO Inferred from Sequence Orthology more info
involved_in cellular response to lipopolysaccharide	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to nutrient levels	ISO Inferred from Sequence Orthology more info
involved_in decidualization	IEP Inferred from Expression Pattern more info	PubMed
involved_in embryo implantation	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within embryo implantation	ISO Inferred from Sequence Orthology more info
involved_in energy homeostasis	ISO Inferred from Sequence Orthology more info
acts_upstream_of epithelial cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of fat cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in fatty acid beta-oxidation	ISO Inferred from Sequence Orthology more info
involved_in fatty acid metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in fatty acid oxidation	IDA Inferred from Direct Assay more info	PubMed
involved_in fatty acid transport	ISO Inferred from Sequence Orthology more info
involved_in heart development	IEP Inferred from Expression Pattern more info	PubMed
involved_in hormone-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within keratinocyte migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within keratinocyte proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lipid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of cell growth	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of cholesterol storage	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of collagen biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
NOT acts_upstream_of_or_within negative regulation of epithelial cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of epithelial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of inflammatory response	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of miRNA transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of myoblast differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of smooth muscle cell migration	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of smooth muscle cell proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
involved_in phospholipid biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within placenta development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of epidermis development	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of fat cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of fatty acid metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of fatty acid oxidation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of insulin secretion involved in cellular response to glucose stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of myoblast proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of skeletal muscle tissue regeneration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteoglycan metabolic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of epithelial cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of fat cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in regulation of skeletal muscle satellite cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in response to activity	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to glucose	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to organic substance	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to vitamin A	IEP Inferred from Expression Pattern more info	PubMed
involved_in vasodilation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within wound healing	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of chromatin	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: peroxisome proliferator-activated receptor delta

Names: peroxisome proliferator activator receptor beta; peroxisome proliferator activator receptor, delta

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_013141.2 → NP_037273.2 peroxisome proliferator-activated receptor delta

See identical proteins and their annotated locations for NP_037273.2

Status: VALIDATED

Source sequence(s)

AJ306400, AW143792, CB326159, CK356918, CO560438, FM033221

UniProtKB/TrEMBL

A6JJP8, F7FM43, Q62879, Q99ND3

Related

ENSRNOP00000045974.3, ENSRNOT00000042539.6

Conserved Domains (2) summary

cd06932
Location:172 → 439

NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors

cd06965
Location:72 → 155

NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086038.1 Reference GRCr8

Range

6300527..6365707

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006256166.5 → XP_006256228.1 peroxisome proliferator-activated receptor delta isoform X1

See identical proteins and their annotated locations for XP_006256228.1

UniProtKB/TrEMBL

A6JJP8, F7FM43, Q62879, Q99ND3

Conserved Domains (2) summary

cd06932
Location:172 → 439

NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors

cd06965
Location:72 → 155

NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
XM_006256167.5 → XP_006256229.1 peroxisome proliferator-activated receptor delta isoform X1

See identical proteins and their annotated locations for XP_006256229.1

UniProtKB/TrEMBL

A6JJP8, F7FM43, Q62879, Q99ND3

Conserved Domains (2) summary

cd06932
Location:172 → 439

NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors

cd06965
Location:72 → 155

NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
XM_006256168.5 → XP_006256230.1 peroxisome proliferator-activated receptor delta isoform X1

See identical proteins and their annotated locations for XP_006256230.1

UniProtKB/TrEMBL

A6JJP8, F7FM43, Q62879, Q99ND3

Conserved Domains (2) summary

cd06932
Location:172 → 439

NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors

cd06965
Location:72 → 155

NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers