Plaur plasminogen activator, urokinase receptor [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Plaurprovided by RGD
Official Full Name: plasminogen activator, urokinase receptorprovided by RGD
Primary source: RGD:620597
See related: Ensembl:ENSRNOG00000037931 AllianceGenome:RGD:620597
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Par; uPAR; Plaur3; uPAR-2; uPAR-3
Summary: Predicted to enable enzyme binding activity; protein domain specific binding activity; and signaling receptor binding activity. Involved in several processes, including epithelial cell differentiation involved in prostate gland development; skeletal muscle tissue regeneration; and spermatogenesis. Predicted to be located in cell surface. Predicted to be integral component of plasma membrane. Predicted to be active in plasma membrane. Biomarker of chronic obstructive pulmonary disease; myocardial infarction; and status epilepticus. Human ortholog(s) of this gene implicated in rheumatoid arthritis. Orthologous to human PLAUR (plasminogen activator, urokinase receptor). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Lung (RPKM 29.6), Spleen (RPKM 22.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q21

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (89181363..89196308)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (80053440..80068384)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (81328171..81344954)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

microRNA-143 targets SIRT2 to mediate the histone acetylation of PLAUR and modulates functions of astrocytes in spinal cord injury.
Title: microRNA-143 targets SIRT2 to mediate the histone acetylation of PLAUR and modulates functions of astrocytes in spinal cord injury.
Increased postmortem PLAUR expression could serve as a biomarker to aid diagnosis of early myocardial infarction.
Title: Can early myocardial infarction-related deaths be diagnosed using postmortem urotensin receptor expression levels?
Rapamycin could promote podocyte migration through the up-regulation of uPAR leading to proteinuria.
Title: Rapamycin promotes podocyte migration through the up-regulation of urokinase receptor.
uPA, uPAR, MMP-2 and MMP-9 play an important role in GBM growth. Blockade of uPA and interruption of the proteolytic cascade could become a useful tool in the therapy of GBM
Title: Urokinase plasminogen activator, uPAR, MMP-2, and MMP-9 in the C6-glioblastoma rat model.
uPAR associates with activating enhancer-binding protein 2alpha (AP2a) and mediates beta-catenin gene transcription.
Title: Urokinase-type plasminogen activator receptor (uPAR)-mediated regulation of WNT/β-catenin signaling is enhanced in irradiated medulloblastoma cells.
uPA and uPAR expressions were significantly increased both at transcriptional and protein level during early phase post myocardial infarct period
Title: uPA, uPAR and TGFβ₁ expression during early and late post myocardial infarction period in rat myocardium.
In animals undergoing SE, uPAR expression increased dramatically, peaking at 1 and 4 days after SE. Increased uPAR expression during post-injury phase supports its contribution to tissue remodeling in the brain.
Title: Expression of urokinase-type plasminogen activator receptor is increased during epileptogenesis in the rat hippocampus.
The members of caspases, MEK1/2, PKC, and NF-kappaB are involved in TRAIL-induced expression of uPA, IL-8, MMP-7 and MMP-9.
Title: The potential molecular mechanism of overexpression of uPA, IL-8, MMP-7 and MMP-9 induced by TRAIL in pancreatic cancer cell.
Linked to spermiation and spermatogenesis via regulating germ cell migration and proliferation, as well as promoting the spermiation and detached residual bodies from the mature spermatids.
Title: Gene expression changes of urokinase plasminogen activator and urokinase receptor in rat testes at postnatal stages.
Domain 2 of the urokinase receptor plays a pivotal role in the regulation of uPAR-integrin alphavbeta3 interactions
Title: Domain 2 of the urokinase receptor contains an integrin-interacting epitope with intrinsic signaling activity: generation of a new integrin inhibitor.

Submit: New GeneRIF Correction See all GeneRIFs (16)

General gene information

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Markers

RH141497 (e-PCR)
- UniSTS:223491

D1Bda3 (e-PCR)
- UniSTS:240337

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables enzyme binding	IEA Inferred from Electronic Annotation more info
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables protein domain specific binding	IEA Inferred from Electronic Annotation more info
enables protein domain specific binding	ISO Inferred from Sequence Orthology more info
enables signaling receptor binding	IEA Inferred from Electronic Annotation more info
enables signaling receptor binding	ISO Inferred from Sequence Orthology more info
enables urokinase plasminogen activator receptor activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in epithelial cell differentiation involved in prostate gland development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mesenchymal cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of intrinsic apoptotic signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of intrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of epidermal growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of epidermal growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of homotypic cell-cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of homotypic cell-cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of release of cytochrome c from mitochondria	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of release of cytochrome c from mitochondria	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in skeletal muscle tissue regeneration	IEP Inferred from Expression Pattern more info	PubMed
involved_in spermatogenesis	IEP Inferred from Expression Pattern more info	PubMed
involved_in urokinase plasminogen activator signaling pathway	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cell surface	IEA Inferred from Electronic Annotation more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of protein complex involved in cell-matrix adhesion	IEA Inferred from Electronic Annotation more info
part_of protein complex involved in cell-matrix adhesion	ISO Inferred from Sequence Orthology more info
part_of serine-type endopeptidase complex	IEA Inferred from Electronic Annotation more info
part_of serine-type endopeptidase complex	ISO Inferred from Sequence Orthology more info
located_in side of membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: urokinase plasminogen activator surface receptor

Names: U-PAR; plasminogen activator urokinase receptor 3; urinary plasminogen activator receptor 2; urinary plasminogen activator receptor 3; urokinase plasminogen activator receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_134352.2 → NP_599179.2 urokinase plasminogen activator surface receptor precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/Swiss-Prot

O35771, P49616, P51573, Q7TN35

UniProtKB/TrEMBL

M0R6Z6

Related

ENSRNOP00000063960.3, ENSRNOT00000075167.4

Conserved Domains (2) summary

smart00134
Location:214 → 295

LU; Ly-6 antigen / uPA receptor -like domain

pfam00021
Location:27 → 101

UPAR_LY6; u-PAR/Ly-6 domain