Fga fibrinogen alpha chain [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Fgaprovided by RGD
Official Full Name: fibrinogen alpha chainprovided by RGD
Primary source: RGD:2603
See related: Ensembl:ENSRNOG00000024848 AllianceGenome:RGD:2603
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Fba5e; Ac1873
Summary: Predicted to enable structural molecule activity. Predicted to contribute to cell adhesion molecule binding activity and signaling receptor binding activity. Involved in several processes, including cellular response to cytokine stimulus; liver regeneration; and response to peptide hormone. Located in blood microparticle and rough endoplasmic reticulum. Used to study asthma; brain ischemia; disseminated intravascular coagulation; and thrombocytopenia. Biomarker of acute kidney failure; disseminated intravascular coagulation; pancreatitis; pulmonary embolism; and pulmonary emphysema. Human ortholog(s) of this gene implicated in brain small vessel disease; congenital afibrinogenemia; familial visceral amyloidosis; and thrombophilia. Orthologous to human FGA (fibrinogen alpha chain). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward (RPKM 13599.1) See more
Orthologs: human mouse all
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Genomic context

Location:: 2q34

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (170672169..170679572)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (168374120..168381523)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (181997562..182013726)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Fibrinopeptide A induces CRP expression in Vascular Smooth Muscle Cells via Reactive Oxygen Species-ERK1/2/p38-NF-kappaB signal pathway.
Title: Fibrinopeptide A Induces Expression of C-Reactive Protein via the ROS-ERK1/2/ P38-NF-κB Signal Pathway in Vascular Smooth Muscle Cells.
Studies suggest fibrin as a homing target molecule in regenerative medicine and the fibrin-targeting therapy may be a generalizable platform technology for tissue injury.
Title: Fibrin-targeting delivery: a novel platform for cardiac regenerative medicine.
These results suggest that immunoreactivity of Fg in the kidney, as well as urinary excretion of Fg, serves as a sensitive and early diagnostic translational biomarker for detection of acute kidney injury.
Title: Fibrinogen excretion in the urine and immunoreactivity in the kidney serves as a translational biomarker for acute kidney injury.

Submit: New GeneRIF Correction

General gene information

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Markers

RH128930 (e-PCR)
- UniSTS:212238

GDB:633003 (e-PCR)
- UniSTS:158506

RH128215 (e-PCR)
- UniSTS:211523

D2Wox16 (e-PCR)
- UniSTS:517815

D2Mit19 (e-PCR), detects polymorphism
- UniSTS:240587

d2arb11 (e-PCR)
- UniSTS:121580

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
contributes_to cell adhesion molecule binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein-macromolecule adaptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables signaling receptor binding	IEA Inferred from Electronic Annotation more info
contributes_to signaling receptor binding	ISO Inferred from Sequence Orthology more info
enables structural molecule activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in acute-phase response	IEP Inferred from Expression Pattern more info	PubMed
involved_in adaptive immune response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within blood coagulation	ISO Inferred from Sequence Orthology more info
involved_in blood coagulation, common pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in blood coagulation, common pathway	ISO Inferred from Sequence Orthology more info
involved_in blood coagulation, fibrin clot formation	ISO Inferred from Sequence Orthology more info
involved_in cell-matrix adhesion	ISO Inferred from Sequence Orthology more info
involved_in cellular response to granulocyte colony-stimulating factor	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to interleukin-6	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to organic cyclic compound	IEP Inferred from Expression Pattern more info	PubMed
involved_in envenomation resulting in modulation of blood coagulation in another organism	IEP Inferred from Expression Pattern more info	PubMed
involved_in fibrinolysis	IBA Inferred from Biological aspect of Ancestor more info
involved_in fibrinolysis	ISO Inferred from Sequence Orthology more info
involved_in induction of bacterial agglutination	ISO Inferred from Sequence Orthology more info
involved_in innate immune response	IEA Inferred from Electronic Annotation more info
involved_in liver regeneration	IEP Inferred from Expression Pattern more info	PubMed
involved_in negative regulation of endothelial cell apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of extrinsic apoptotic signaling pathway via death domain receptors	ISO Inferred from Sequence Orthology more info
involved_in plasminogen activation	ISO Inferred from Sequence Orthology more info
involved_in platelet aggregation	IBA Inferred from Biological aspect of Ancestor more info
involved_in platelet aggregation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of exocytosis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of heterotypic cell-cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of heterotypic cell-cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of peptide hormone secretion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein secretion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of smooth muscle cell migration	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of vasoconstriction	ISO Inferred from Sequence Orthology more info
involved_in protein polymerization	IEA Inferred from Electronic Annotation more info
involved_in protein polymerization	ISO Inferred from Sequence Orthology more info
involved_in protein-containing complex assembly	ISO Inferred from Sequence Orthology more info
involved_in response to X-ray	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to calcium ion	ISO Inferred from Sequence Orthology more info
involved_in response to cycloheximide	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to estradiol	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to genistein	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to growth hormone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to insulin	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to thyroid hormone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to toxic substance	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in blood microparticle	IDA Inferred from Direct Assay more info	PubMed
located_in cell cortex	IEA Inferred from Electronic Annotation more info
located_in cell cortex	ISO Inferred from Sequence Orthology more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in external side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	ISO Inferred from Sequence Orthology more info
part_of fibrinogen complex	IBA Inferred from Biological aspect of Ancestor more info
part_of fibrinogen complex	IEA Inferred from Electronic Annotation more info
part_of fibrinogen complex	ISO Inferred from Sequence Orthology more info
located_in platelet alpha granule	ISO Inferred from Sequence Orthology more info
located_in synapse	IEA Inferred from Electronic Annotation more info
is_active_in synapse	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: fibrinogen alpha chain

Names: fibrinogen, A alpha polypeptide; fibrinogen, alpha polypeptide

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001008724.2 → NP_001008724.1 fibrinogen alpha chain isoform 1 precursor

See identical proteins and their annotated locations for NP_001008724.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000002

UniProtKB/Swiss-Prot

P06399

UniProtKB/TrEMBL

A0A9K3Y6Z7, D3ZJ95, Q7TQ70

Related

ENSRNOP00000060007.2, ENSRNOT00000064091.4

Conserved Domains (3) summary

cd00087
Location:546 → 779

FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...

pfam08702
Location:51 → 189

Fib_alpha; Fibrinogen alpha/beta chain family

pfam12160
Location:388 → 453

Fibrinogen_aC; Fibrinogen alpha C domain
NM_052797.1 → NP_434684.1 fibrinogen alpha chain isoform 2 precursor

See identical proteins and their annotated locations for NP_434684.1

Status: PROVISIONAL

Source sequence(s)

BC127465

UniProtKB/TrEMBL

A1L114

Conserved Domains (2) summary

pfam08702
Location:51 → 189

Fib_alpha; Fibrinogen alpha/beta chain family

pfam12160
Location:388 → 453

Fibrinogen_aC; Fibrinogen alpha C domain