FABP7 fatty acid binding protein 7 [Homo sapiens (human)] - Gene

Summary

Official Symbol: FABP7provided by HGNC
Official Full Name: fatty acid binding protein 7provided by HGNC
Primary source: HGNC:HGNC:3562
See related: Ensembl:ENSG00000164434 MIM:602965; AllianceGenome:HGNC:3562
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: MRG; BLBP; FABPB; B-FABP
Summary: The gene encodes a small, highly conserved cytoplasmic protein that bind long-chain fatty acids and other hydrophobic ligands. The encoded protein is important in the establishment of the radial glial fiber in the developing brain. Alternative splicing and promoter usage results in multiple transcript variants encoding different isoforms. Pseudogenes of this gene are found on multiple chromosomes. [provided by RefSeq, Jan 2016]
Expression: Biased expression in brain (RPKM 8.9) and skin (RPKM 0.4) See more
Orthologs: mouse all
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Genomic context

Location:: 6q22.31

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	6	NC_000006.12 (122749201..122784074)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	6	NC_060930.1 (123937487..123972367)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	6	NC_000006.11 (123070346..123105219)

Chromosome 6 - NC_000006.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

FABP7 drives an inflammatory response in human astrocytes and is upregulated in Alzheimer's disease.
Title: FABP7 drives an inflammatory response in human astrocytes and is upregulated in Alzheimer's disease.
Stationary-to-migratory transition in glioblastoma stem-like cells driven by a fatty acid-binding protein 7-RXRalpha neurogenic pathway.
Title: Stationary-to-migratory transition in glioblastoma stem-like cells driven by a fatty acid-binding protein 7-RXRα neurogenic pathway.
The HOPX and BLBP landscape and gliogenic regions in developing human brain.
Title: The HOPX and BLBP landscape and gliogenic regions in developing human brain.
Oleic acid-bound FABP7 drives glioma cell proliferation through regulation of nuclear lipid droplet formation.
Title: Oleic acid-bound FABP7 drives glioma cell proliferation through regulation of nuclear lipid droplet formation.
Metastatic Tumor Cell-Specific FABP7 Promotes NSCLC Metastasis via Inhibiting beta-Catenin Degradation.
Title: Metastatic Tumor Cell-Specific FABP7 Promotes NSCLC Metastasis via Inhibiting β-Catenin Degradation.
Silencing of circular RNA PUM1 inhibits clear cell renal cell carcinoma progression through the miR-340-5p/FABP7 axis.
Title: Silencing of circular RNA PUM1 inhibits clear cell renal cell carcinoma progression through the miR-340-5p/FABP7 axis.
Circ_ZFR affects FABP7 expression to regulate breast cancer progression by acting as a sponge for miR-223-3p.
Title: Circ_ZFR affects FABP7 expression to regulate breast cancer progression by acting as a sponge for miR-223-3p.
Nuclear FABP7 regulates cell proliferation of wild-type IDH1 glioma through caveolae formation.
Title: Nuclear FABP7 regulates cell proliferation of wild-type IDH1 glioma through caveolae formation.
Plasma fatty acid-binding protein 7 concentration correlates with depression/anxiety, cognition, and positive symptom in patients with schizophrenia.
Title: Plasma fatty acid-binding protein 7 concentration correlates with depression/anxiety, cognition, and positive symptom in patients with schizophrenia.
FABP7 Facilitates Uptake of Docosahexaenoic Acid in Glioblastoma Neural Stem-like Cells.
Title: FABP7 Facilitates Uptake of Docosahexaenoic Acid in Glioblastoma Neural Stem-like Cells.

Submit: New GeneRIF Correction See all GeneRIFs (65)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables fatty acid binding	IBA Inferred from Biological aspect of Ancestor more info
enables lipid binding	TAS Traceable Author Statement more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in epithelial cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in fatty acid transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of cell population proliferation	TAS Traceable Author Statement more info	PubMed
involved_in nervous system development	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	TAS Traceable Author Statement more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: fatty acid-binding protein, brain

Names: brain lipid-binding protein; brain-type fatty acid-binding protein; hypothetical protein DKFZp547J2313; mammary-derived growth inhibitor-related

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_050619.1 RefSeqGene

Range

35516..39874

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001319039.2 → NP_001305968.1 fatty acid-binding protein, brain isoform 2

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 3' coding region and 3' UTR compared to variant 1. The encoded isoform (2) has a distinct C-terminus and is longer than isoform 1.

Source sequence(s)

AL512688, AL645811, BI860090

Consensus CDS

CCDS83121.1

UniProtKB/Swiss-Prot

O15540

Related

ENSP00000348931.4, ENST00000356535.4

Conserved Domains (1) summary

pfam00061
Location:8 → 117

Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family
NM_001319041.2 → NP_001305970.1 fatty acid-binding protein, brain isoform 3

Status: REVIEWED

Description

Transcript Variant: This variant (3) retains two alternate segments compared to variant 1, resulting in a distinct 3' coding region and 3' UTR. The encoded isoform (3) has a distinct C-terminus and is shorter than isoform 1.

Source sequence(s)

AB208815, AL645811, BI860090, BU736791, BX461253

UniProtKB/TrEMBL

Q59HE4

Conserved Domains (1) summary

cl10502
Location:2 → 82

lipocalin_FABP; lipocalin/cytosolic fatty acid-binding protein family
NM_001319042.2 → NP_001305971.1 fatty acid-binding protein, brain isoform 4

Status: REVIEWED

Description

Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon compared to variant 1. The encoded isoform (4) has a distinct N-terminus and is shorter than isoform 1. The 5' end of this transcript contains long terminal repeat (LTR) sequence and initiates from an LTR promoter. (PMID: 25114248)

Source sequence(s)

AW156936, KM111186

UniProtKB/TrEMBL

A0A077H155

Conserved Domains (1) summary

pfam00061
Location:21 → 128

Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family
NM_001446.5 → NP_001437.1 fatty acid-binding protein, brain isoform 1

See identical proteins and their annotated locations for NP_001437.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes isoform 1.

Source sequence(s)

AW156936, BC012299

Consensus CDS

CCDS5127.1

UniProtKB/Swiss-Prot

B2R4L1, O14951, O15540, Q6IAU7, Q9H047

Related

ENSP00000357429.3, ENST00000368444.8

Conserved Domains (1) summary

pfam00061
Location:8 → 132

Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family