MIOX myo-inositol oxygenase [Homo sapiens (human)] - Gene

Summary

Official Symbol: MIOXprovided by HGNC
Official Full Name: myo-inositol oxygenaseprovided by HGNC
Primary source: HGNC:HGNC:14522
See related: Ensembl:ENSG00000100253 MIM:606774; AllianceGenome:HGNC:14522
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: ALDRL6
Summary: Enables ferric iron binding activity and inositol oxygenase activity. Involved in inositol catabolic process. Predicted to be located in cytoplasm and inclusion body. [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward kidney (RPKM 162.3) See more
Orthologs: mouse all
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Genomic context

Location:: 22q13.33

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	22	NC_000022.11 (50486859..50490648)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	22	NC_060946.1 (50996041..50999830)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	22	NC_000022.10 (50925288..50929077)

Chromosome 22 - NC_000022.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MIOX inhibits autophagy to regulate the ROS -driven inhibition of STAT3/c-Myc-mediated epithelial-mesenchymal transition in clear cell renal cell carcinoma.
Title: MIOX inhibits autophagy to regulate the ROS -driven inhibition of STAT3/c-Myc-mediated epithelial-mesenchymal transition in clear cell renal cell carcinoma.
Myo-inositol oxygenase (MIOX) accelerated inflammation in the model of infection-induced cardiac dysfunction by NLRP3 inflammasome.
Title: Myo-inositol oxygenase (MIOX) accelerated inflammation in the model of infection-induced cardiac dysfunction by NLRP3 inflammasome.
Long noncoding RNA NEAT1 promotes ferroptosis by modulating the miR-362-3p/MIOX axis as a ceRNA.
Title: Long noncoding RNA NEAT1 promotes ferroptosis by modulating the miR-362-3p/MIOX axis as a ceRNA.
Myo-inositol Oxygenase (MIOX) Overexpression Drives the Progression of Renal Tubulointerstitial Injury in Diabetes.
Title: Myo-inositol Oxygenase (MIOX) Overexpression Drives the Progression of Renal Tubulointerstitial Injury in Diabetes.
MIOX-induced oxidant stress and tunicamycin-induced endoplasmic reticulum stress are interlinked, and both of the events may feed into each other to amplify the tubulointerstitial injury.
Title: Myo-inositol oxygenase accentuates renal tubular injury initiated by endoplasmic reticulum stress.
increased MIOX expression in the kidney contributes to tubular damage in DN (Diabetic Nephropathy). The concentration of MIOX in the serum and urine may serve as a new biomarker for the early diagnosis of DN.
Title: The Kidney Specific Protein myo-Inositol Oxygenase, a Potential Biomarker for Diabetic Nephropathy.
Our results suggest that serum MIOX levels do not change in polycystic ovary syndrome. It was, therefore, concluded that myoinositol deficiency observed in PCOS was not related to the level of MIOX enzyme which cleaves myoinositol.
Title: Does myo-inositol oxygenase, the only enzyme to catalyze myo-inositol in vivo, play a role in the etiology of polycystic ovarian syndrome?
these findings highlight the epigenetic regulation of MIOX in the pathogenesis of diabetic tubulopathy.
Title: High Glucose-Induced Hypomethylation Promotes Binding of Sp-1 to Myo-Inositol Oxygenase: Implication in the Pathobiology of Diabetic Tubulopathy.
Data suggest that MIOX expression/activity is up-regulated in kidneys tubules during oxidative stress (as in obesity and diabetic nephropathy); up-regulation of MIOX activity is related to phosphorylation of serine/threonine residues.
Title: Transcriptional and Translational Modulation of myo-Inositol Oxygenase (Miox) by Fatty Acids: IMPLICATIONS IN RENAL TUBULAR INJURY INDUCED IN OBESITY AND DIABETES.
results demonstrated that the polymorphism (rs761745) in the promoter region of myo-inositol oxygenase(MIOX) gene may be associated with the development of type 1 diabetes mellitus in our studied population
Title: Polymorphisms of myo-inositol oxygenase gene are associated with Type 1 diabetes mellitus.

Submit: New GeneRIF Correction See all GeneRIFs (14)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH48341 (e-PCR)
- UniSTS:46358

D8S2279 (e-PCR)
- UniSTS:473907

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables aldo-keto reductase (NADPH) activity	ISS Inferred from Sequence or Structural Similarity more info
enables ferric iron binding	IDA Inferred from Direct Assay more info	PubMed
enables inositol oxygenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables inositol oxygenase activity	IDA Inferred from Direct Assay more info	PubMed
enables inositol oxygenase activity	ISS Inferred from Sequence or Structural Similarity more info
enables oxidoreductase activity, acting on NAD(P)H	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in inositol catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in inositol catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in inositol catabolic process	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	TAS Traceable Author Statement more info
located_in inclusion body	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: inositol oxygenase

Names: MI oxygenase; aldehyde reductase (aldose reductase) like 6; aldehyde reductase-like 6; kidney-specific protein 32; renal-specific oxidoreductase

NP_060054.4

EC 1.13.99.1

XP_005261982.1

EC 1.13.99.1

XP_011529007.1

EC 1.13.99.1

XP_047297399.1

EC 1.13.99.1

XP_054181762.1

EC 1.13.99.1

XP_054181763.1

EC 1.13.99.1

XP_054181764.1

EC 1.13.99.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_017584.6 → NP_060054.4 inositol oxygenase

See identical proteins and their annotated locations for NP_060054.4

Status: VALIDATED

Source sequence(s)

AF197129, AL096767, BC012025, BC064395

Consensus CDS

CCDS14092.1

UniProtKB/Swiss-Prot

Q05DJ6, Q5S8C9, Q9BZZ1, Q9UGB7, Q9UHB8

UniProtKB/TrEMBL

A6PVH4

Related

ENSP00000216075.6, ENST00000216075.11

Conserved Domains (1) summary

pfam05153
Location:37 → 285

MIOX; Myo-inositol oxygenase

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000022.11 Reference GRCh38.p14 Primary Assembly

Range

50486859..50490648

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047441443.1 → XP_047297399.1 inositol oxygenase isoform X3

Related

ENSP00000379082.3, ENST00000395733.7
XM_011530705.3 → XP_011529007.1 inositol oxygenase isoform X2

Conserved Domains (1) summary

pfam05153
Location:37 → 113

MIOX; Myo-inositol oxygenase
XM_005261925.5 → XP_005261982.1 inositol oxygenase isoform X1

UniProtKB/TrEMBL

A6PVH4

Conserved Domains (1) summary

pfam05153
Location:1 → 239

MIOX; Myo-inositol oxygenase