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    Procr protein C receptor, endothelial [ Mus musculus (house mouse) ]

    Gene ID: 19124, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Procrprovided by MGI
    Official Full Name
    protein C receptor, endothelialprovided by MGI
    Primary source
    MGI:MGI:104596
    See related
    Ensembl:ENSMUSG00000027611 AllianceGenome:MGI:104596
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ccca; Epcr; Ccd41
    Summary
    Predicted to enable protein C-terminus binding activity. Predicted to be involved in negative regulation of coagulation. Predicted to act upstream of or within blood coagulation. Located in centrosome. Is expressed in several structures, including blastocyst; endocardial tissue; female reproductive system; liver; and vascular element. Orthologous to human PROCR (protein C receptor). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in placenta adult (RPKM 44.4), bladder adult (RPKM 5.1) and 8 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    2 H1; 2 77.26 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (155592159..155597391)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (155751125..155755478)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene transient receptor potential cation channel, subfamily C, member 4 associated protein Neighboring gene predicted gene, 22334 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:155505379-155505532 Neighboring gene ER degradation enhancer, mannosidase alpha-like 2 Neighboring gene STARR-positive B cell enhancer ABC_E10157 Neighboring gene STARR-seq mESC enhancer starr_06149 Neighboring gene matrix metallopeptidase 24 Neighboring gene predicted gene, 46772 Neighboring gene STARR-positive B cell enhancer ABC_E4512 Neighboring gene matrix metallopeptidase 24 opposite strand transcript 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Differential expression of endothelial protein C receptor (EPCR) in hematopoietic stem and multipotent progenitor cells in young and old mice. Lin DS, et al. Cells Dev, 2023 Jun. PMID 37080459
    2. Endothelial cell protein C receptor regulates neutrophil extracellular trap-mediated rheumatoid arthritis disease progression. Liu X, et al. Int Immunopharmacol, 2022 Nov. PMID 36152537
    3. Endothelial Cell Protein C Receptor Deficiency Attenuates Streptococcus pneumoniae-induced Pleural Fibrosis. Keshava S, et al. Am J Respir Cell Mol Biol, 2021 Apr. PMID 33600743, Free PMC Article
    4. Chromatin regulatory dynamics of early human small intestinal development using a directed differentiation model. Hung YH, et al. Nucleic Acids Res, 2021 Jan 25. PMID 33406262, Free PMC Article
    5. A critical role of endothelial cell protein C receptor in the intestinal homeostasis in experimental colitis. Kondreddy V, et al. Sci Rep, 2020 Nov 25. PMID 33239717, Free PMC Article

    See all (90) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. EPCR deficiency ameliorates inflammatory arthritis in mice by suppressing the activation and migration of T cells and dendritic cells.
      Title: EPCR deficiency ameliorates inflammatory arthritis in mice by suppressing the activation and migration of T cells and dendritic cells.
    2. Endothelial Protein C Receptor and 3K3A-Activated Protein C Protect Mice from Allergic Contact Dermatitis in a Contact Hypersensitivity Model.
      Title: Endothelial Protein C Receptor and 3K3A-Activated Protein C Protect Mice from Allergic Contact Dermatitis in a Contact Hypersensitivity Model.
    3. Differential expression of endothelial protein C receptor (EPCR) in hematopoietic stem and multipotent progenitor cells in young and old mice.
      Title: Differential expression of endothelial protein C receptor (EPCR) in hematopoietic stem and multipotent progenitor cells in young and old mice.
    4. Endothelial cell protein C receptor regulates neutrophil extracellular trap-mediated rheumatoid arthritis disease progression.
      Title: Endothelial cell protein C receptor regulates neutrophil extracellular trap-mediated rheumatoid arthritis disease progression.
    5. The endothelial protein C receptor plays an essential role in the maintenance of pregnancy.
      Title: The endothelial protein C receptor plays an essential role in the maintenance of pregnancy.
    6. Activated Protein C Strengthens Cardiac Tolerance to Ischemic Insults in Aging.
      Title: Activated Protein C Strengthens Cardiac Tolerance to Ischemic Insults in Aging.
    7. Endothelial Cell Protein C Receptor Deficiency Attenuates Streptococcus pneumoniae-induced Pleural Fibrosis.
      Title: Endothelial Cell Protein C Receptor Deficiency Attenuates Streptococcus pneumoniae-induced Pleural Fibrosis.
    8. Lipid presentation by the protein C receptor links coagulation with autoimmunity.
      Title: Lipid presentation by the protein C receptor links coagulation with autoimmunity.
    9. EPCR deficiency or function-blocking antibody protects against joint bleeding-induced pathology in hemophilia mice.
      Title: EPCR deficiency or function-blocking antibody protects against joint bleeding-induced pathology in hemophilia mice.
    10. Elevated levels of soluble Endothelial protein C receptor in rheumatoid arthritis and block the therapeutic effect of protein C in collagen-induced arthritis.
      Title: Elevated levels of soluble Endothelial protein C receptor in rheumatoid arthritis and block the therapeutic effect of protein C in collagen-induced arthritis.
    Submit: New GeneRIF Correction See all GeneRIFs (47)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (11)  1 citation
    • Endonuclease-mediated (7) 

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within blood coagulation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within hemostasis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of coagulation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of coagulation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of coagulation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    endothelial protein C receptor
    Names
    APC receptor
    CD antigen CD201
    activated protein C receptor
    centrocyclin
    centrosomal protein CCD41
    endothelial cell protein C receptor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001420719.1 → NP_001407648.1  endothelial protein C receptor isoform b

      Status: VALIDATED

      Source sequence(s)
      AL929233

    2. NM_001420720.1 → NP_001407649.1  endothelial protein C receptor isoform b

      Status: VALIDATED

      Source sequence(s)
      AL929233

    3. NM_011171.3 → NP_035301.2  endothelial protein C receptor isoform a precursor

      See identical proteins and their annotated locations for NP_035301.2

      Status: VALIDATED

      Source sequence(s)
      AL929233
      Consensus CDS
      CCDS16954.1
      UniProtKB/Swiss-Prot
      Q4FK76, Q64695, Q9WV33
      Related
      ENSMUSP00000029140.6, ENSMUST00000029140.12
      Conserved Domains (1) summary
      cl08246
      Location:21 → 194
      MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      155592159..155597391
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006498955.3 → XP_006499018.1  endothelial protein C receptor isoform X1

      See identical proteins and their annotated locations for XP_006499018.1

      UniProtKB/TrEMBL
      Q8K357
      Conserved Domains (1) summary
      cl08246
      Location:20 → 194
      MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q64695.3 GenPept UniProtKB/Swiss-Prot:Q64695

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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