Rnase4 ribonuclease A family member 4 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Rnase4provided by RGD
Official Full Name: ribonuclease A family member 4provided by RGD
Primary source: RGD:61823
See related: Ensembl:ENSRNOG00000025625 AllianceGenome:RGD:61823
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Rab1
Summary: Predicted to enable ribonuclease activity. Predicted to be involved in RNA phosphodiester bond hydrolysis. Predicted to act upstream of or within cellular response to starvation. Predicted to be located in extracellular region. Predicted to be part of proton-transporting V-type ATPase, V1 domain. Predicted to be active in extracellular space. Orthologous to human RNASE4 (ribonuclease A family member 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Liver (RPKM 2203.4), Lung (RPKM 126.0) and 1 other tissue See more
Orthologs: human mouse all
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Genomic context

Location:: 15p14

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	15	NC_086033.1 (26786287..26803634)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	15	NC_051350.1 (24312765..24330112)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	15	NC_005114.4 (28018040..28035395)

Chromosome 15 - NC_086033.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables RNA nuclease activity	IBA Inferred from Biological aspect of Ancestor more info
enables RNA nuclease activity	ISO Inferred from Sequence Orthology more info
enables endonuclease activity	IEA Inferred from Electronic Annotation more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables proton-transporting ATPase activity, rotational mechanism	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in antibacterial humoral response	ISO Inferred from Sequence Orthology more info
involved_in antibacterial humoral response	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within cellular response to starvation	ISO Inferred from Sequence Orthology more info
involved_in defense response to Gram-positive bacterium	IBA Inferred from Biological aspect of Ancestor more info
involved_in proton transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular region	ISO Inferred from Sequence Orthology more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in extracellular space	ISS Inferred from Sequence or Structural Similarity more info
part_of proton-transporting V-type ATPase, V1 domain	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ribonuclease 4

Names: RL3; RNase 4; ribonuclease A b1; ribonuclease, RNase A family 4

NP_064467.1

EC 3.1.27.-

XP_063130661.1

EC 3.1.27.-

XP_063130662.1

EC 3.1.27.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_020082.2 → NP_064467.1 ribonuclease 4 precursor

See identical proteins and their annotated locations for NP_064467.1

Status: PROVISIONAL

Source sequence(s)

BC070953

UniProtKB/Swiss-Prot

O55004

UniProtKB/TrEMBL

W0UVG1

Related

ENSRNOP00000043003.2, ENSRNOT00000041495.5

Conserved Domains (1) summary

smart00092
Location:29 → 147

RNAse_Pc; Pancreatic ribonuclease

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086033.1 Reference GRCr8

Range

26786287..26803634

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063274591.1 → XP_063130661.1 ribonuclease 4 isoform X1

UniProtKB/Swiss-Prot

O55004

UniProtKB/TrEMBL

W0UVG1
XM_063274592.1 → XP_063130662.1 ribonuclease 4 isoform X1

UniProtKB/Swiss-Prot

O55004

UniProtKB/TrEMBL

W0UVG1