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    Spring1 SREBF pathway regulator in golgi 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 498188, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Spring1provided by RGD
    Official Full Name
    SREBF pathway regulator in golgi 1provided by RGD
    Primary source
    RGD:1562310
    See related
    Ensembl:ENSRNOG00000001123 AllianceGenome:RGD:1562310
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1562310
    Summary
    Predicted to be involved in positive regulation of SREBP signaling pathway. Predicted to be located in Golgi membrane. Orthologous to human SPRING1 (SREBF pathway regulator in golgi 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Brain (RPKM 59.7), Heart (RPKM 54.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Spring1 in Genome Data Viewer
    Location:
    12q16
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (43967146..43990083, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (38306227..38329175, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (43920564..43940798, complement)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102553129 Neighboring gene uncharacterized LOC134481204 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene ring finger protein, transmembrane 2 Neighboring gene uncharacterized LOC102553921 Neighboring gene harakiri, BCL2 interacting protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in positive regulation of SREBP signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    SREBP regulating gene protein
    Names
    UPF0454 protein C12orf49 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001109066.2 → NP_001102536.1  SREBP regulating gene protein

      See identical proteins and their annotated locations for NP_001102536.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000012
      UniProtKB/TrEMBL
      A0A8I5ZXJ0, A6J1L7, D3ZTN6
      Related
      ENSRNOP00000001485.4, ENSRNOT00000001485.5
      Conserved Domains (1) summary
      pfam10218
      Location:72 → 195
      DUF2054; Uncharacterized conserved protein (DUF2054)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      43967146..43990083 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063271595.1 → XP_063127665.1  SREBP regulating gene protein isoform X1

    2. XM_063271596.1 → XP_063127666.1  SREBP regulating gene protein isoform X1

    3. XM_063271597.1 → XP_063127667.1  SREBP regulating gene protein isoform X2

    4. XM_039089707.2 → XP_038945635.1  SREBP regulating gene protein isoform X3

      Conserved Domains (2) summary
      cl00342
      Location:55 → 115
      Trp-synth-beta_II; Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan ...
      pfam10218
      Location:72 → 91
      DUF2054; Uncharacterized conserved protein (DUF2054)
    Nucleotide Protein Strain
    Heading Accession and Version

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