Baat bile acid CoA:amino acid N-acyltransferase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Baatprovided by RGD
Official Full Name: bile acid CoA:amino acid N-acyltransferaseprovided by RGD
Primary source: RGD:2190
See related: Ensembl:ENSRNOG00000007395 AllianceGenome:RGD:2190
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: kan-1
Summary: Enables glycine N-choloyltransferase activity. Involved in animal organ regeneration; bile acid conjugation; and liver development. Located in cytosol and peroxisome. Human ortholog(s) of this gene implicated in disease of metabolism. Orthologous to human BAAT (bile acid-CoA:amino acid N-acyltransferase). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward (RPKM 4510.7) See more
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Genomic context

Location:: 5q22

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (68647166..68656137, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (63851668..63860641, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (64768397..64777368, complement)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Dex restored the expression of rBAT in septic rats by enhancing RXR[alpha], a process that might explain the mechanism underlying Dex's anticholestatic effect.
Title: Retinoid X receptor alpha participation in dexamethasone-induced rat bile acid coenzyme A-amino acid N-acyltransferase expression in septic liver.
mechanisms of RXR-alpha-mediated BAAT regulation during polymicrobial sepsis
Title: Role of retinoid-X receptor-alpha in the suppression of rat bile acid coenzyme A-amino acid N-acyltransferase in liver during sepsis.
is capable of forming both taurine and glycine bile acid conjugates and the enzyme is localized primarily in peroxisomes in rat liver
Title: Rat liver bile acid CoA:amino acid N-acyltransferase: expression, characterization, and peroxisomal localization.
hBAAT and rBaat are peroxisomal enzymes present in undetectable amounts in the cytosol. Unconjugated or deconjugated bile salts returning to the liver need to shuttle through the peroxisome before reentering the enterohepatic circulation.
Title: Human and rat bile acid-CoA:amino acid N-acyltransferase are liver-specific peroxisomal enzymes: implications for intracellular bile salt transport.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables N-acyltransferase activity	ISO Inferred from Sequence Orthology more info
enables carboxylic ester hydrolase activity	IEA Inferred from Electronic Annotation more info
enables choloyl-CoA hydrolase activity	IEA Inferred from Electronic Annotation more info
enables fatty acyl-CoA hydrolase activity	IBA Inferred from Biological aspect of Ancestor more info
enables glycine N-choloyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables glycine N-choloyltransferase activity	ISO Inferred from Sequence Orthology more info
enables long-chain fatty acyl-CoA hydrolase activity	ISO Inferred from Sequence Orthology more info
enables medium-chain fatty acyl-CoA hydrolase activity	ISO Inferred from Sequence Orthology more info
enables very long-chain fatty acyl-CoA hydrolase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in acyl-CoA metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in acyl-CoA metabolic process	ISO Inferred from Sequence Orthology more info
involved_in animal organ regeneration	IEP Inferred from Expression Pattern more info	PubMed
involved_in bile acid biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in bile acid conjugation	IDA Inferred from Direct Assay more info	PubMed
involved_in bile acid conjugation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within bile acid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in fatty acid metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in glycine metabolic process	ISO Inferred from Sequence Orthology more info
involved_in liver development	IEP Inferred from Expression Pattern more info	PubMed
involved_in taurine metabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
is_active_in peroxisome	IBA Inferred from Biological aspect of Ancestor more info
located_in peroxisome	IDA Inferred from Direct Assay more info	PubMed
located_in peroxisome	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: bile acid-CoA:amino acid N-acyltransferase

Names: BACAT; BAT; bile acid Coenzyme A: amino acid N-acyltransferase (glycine N-choloyltransferase); bile acid-CoA thioesterase; bile acid-Coenzyme A dehydrogenase: amino acid n-acyltransferase; bile acid-Coenzyme A: amino acid N-acyltransferase; choloyl-CoA hydrolase; glycine N-choloyltransferase; long-chain fatty-acyl-CoA hydrolase

NP_058996.2

EC 2.3.1.65

EC 3.1.2.2

EC 3.1.2.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_017300.2 → NP_058996.2 bile acid-CoA:amino acid N-acyltransferase

See identical proteins and their annotated locations for NP_058996.2

Status: PROVISIONAL

Source sequence(s)

BC088153

UniProtKB/Swiss-Prot

Q5M8A2, Q63276

UniProtKB/TrEMBL

A6KJE5

Related

ENSRNOP00000009777.2, ENSRNOT00000009777.6

Conserved Domains (2) summary

pfam04775
Location:14 → 140

Bile_Hydr_Trans; Acyl-CoA thioester hydrolase/BAAT N-terminal region

pfam08840
Location:206 → 414

BAAT_C; BAAT / Acyl-CoA thioester hydrolase C terminal