Kap kidney androgen regulated protein [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Kapprovided by MGI
Official Full Name: kidney androgen regulated proteinprovided by MGI
Primary source: MGI:MGI:96653
See related: Ensembl:ENSMUSG00000032758 AllianceGenome:MGI:96653
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: FKSG22
Summary: Predicted to be located in extracellular region. Is expressed in several structures, including adrenal gland; genitourinary system; incisor; lung; and midbrain. [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward kidney adult (RPKM 2492.7) See more
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Genomic context

Location:: 6 G1; 6 64.03 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (133826818..133830630, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (133849855..133853667, complement)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

transgenic mice overexpressing protein specifically in kidney show hypertension associated with oxidative stress
Title: Increased oxidative stress, the renin-angiotensin system, and sympathetic overactivation induce hypertension in kidney androgen-regulated protein transgenic mice.
Overexpression of this gene induces hypertension and chronic renal disease.
Title: Kidney androgen-regulated protein transgenic mice show hypertension and renal alterations mediated by oxidative stress.
defined the minimal Kap147 promoter that may be a good model for the study of kidney PTC-specific expression and molecular mechanisms that lead to an androgen-specific responsiveness in vivo
Title: Identification and characterization of the minimal androgen-regulated kidney-specific kidney androgen-regulated protein gene promoter.
Thyroid hormone modulates CCAAT/enhancer binding protein alpha and beta levels that, in turn, control KAP expression in proximal convoluted tubules cells in developmentally dependent manner.
Title: CCAAT/enhancer binding protein-mediated role of thyroid hormone in the developmental expression of the kidney androgen-regulated protein gene in proximal convoluted tubules.
regulation of KAP promoter in kidney tubules
Title: Hormone-specific regulation of the kidney androgen-regulated gene promoter in cultured mouse renal proximal-tubule cells.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1)
Endonuclease-mediated (2)

General gene information

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Markers

NoName (e-PCR)
- UniSTS:224265

Kap (e-PCR), detects polymorphism
- UniSTS:143649

AW146435 (e-PCR)
- UniSTS:179502

D6Uwa8 (e-PCR), detects polymorphism
- UniSTS:142644

D6Mit111 (e-PCR), detects polymorphism
- UniSTS:116329

Gene Ontology Provided by MGI

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: kidney androgen-regulated protein

Names: ARP

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.