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    Paqr5 progestin and adipoQ receptor family member V [ Mus musculus (house mouse) ]

    Gene ID: 74090, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Paqr5provided by MGI
    Official Full Name
    progestin and adipoQ receptor family member Vprovided by MGI
    Primary source
    MGI:MGI:1921340
    See related
    Ensembl:ENSMUSG00000032278 AllianceGenome:MGI:1921340
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mPRg; 0610010I15Rik
    Summary
    Predicted to enable signaling receptor activity. Predicted to act upstream of or within oogenesis. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Is expressed in late tubule. Orthologous to human PAQR5 (progestin and adipoQ receptor family member 5). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in testis adult (RPKM 97.4), kidney adult (RPKM 47.4) and 3 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    9 B; 9 33.52 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (61861020..61934085, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (61953738..62026852, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E6748 Neighboring gene ribosomal protein lateral stalk subunit P1 Neighboring gene kinesin family member 23 Neighboring gene STARR-positive B cell enhancer mm9_chr9:61794519-61794820 Neighboring gene STARR-positive B cell enhancer mm9_chr9:61795876-61796177 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:61808677-61808878 Neighboring gene STARR-positive B cell enhancer ABC_E5075 Neighboring gene predicted gene, 35152 Neighboring gene glucuronyl C5-epimerase Neighboring gene STARR-positive B cell enhancer ABC_E570 Neighboring gene STARR-seq mESC enhancer starr_24364 Neighboring gene microRNA 5133 Neighboring gene predicted gene, 39351

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Membrane progestin receptors alpha and gamma in renal epithelium. Lemale J, et al. Biochim Biophys Acta, 2008 Dec. PMID 18722485
    2. Activation of enteroendocrine membrane progesterone receptors promotes incretin secretion and improves glucose tolerance in mice. Flock GB, et al. Diabetes, 2013 Jan. PMID 22933106, Free PMC Article
    3. PAQR proteins: a novel membrane receptor family defined by an ancient 7-transmembrane pass motif. Tang YT, et al. J Mol Evol, 2005 Sep. PMID 16044242
    4. GUDMAP: the genitourinary developmental molecular anatomy project. McMahon AP, et al. J Am Soc Nephrol, 2008 Apr. PMID 18287559
    5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC118370

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables signaling receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables steroid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within oogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    membrane progestin receptor gamma
    Names
    mPR gamma
    membrane progesterone P4 receptor gamma
    membrane progesterone receptor gamma
    progesterone and adipoQ receptor family member 5
    progestin and adipoQ receptor family member 5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001417861.1 → NP_001404790.1  membrane progestin receptor gamma isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC151969
      UniProtKB/TrEMBL
      Q497J6
      Related
      ENSMUSP00000109623.2, ENSMUST00000113990.2

    2. NM_001417862.1 → NP_001404791.1  membrane progestin receptor gamma isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC151969

    3. NM_001417863.1 → NP_001404792.1  membrane progestin receptor gamma isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC151969

    4. NM_028748.3 → NP_083024.1  membrane progestin receptor gamma isoform 1

      See identical proteins and their annotated locations for NP_083024.1

      Status: VALIDATED

      Source sequence(s)
      AC151969
      Consensus CDS
      CCDS23261.1
      UniProtKB/Swiss-Prot
      Q7TPQ5, Q8C6Z8, Q9DCU0
      Related
      ENSMUSP00000034817.5, ENSMUST00000034817.11
      Conserved Domains (1) summary
      pfam03006
      Location:43 → 269
      HlyIII; Haemolysin-III related

    RNA

    1. NR_184645.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC151969

    2. NR_184646.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC151969

    3. NR_184647.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC151969
      Related
      ENSMUST00000135050.2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      61861020..61934085 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9DCU0.1 GenPept UniProtKB/Swiss-Prot:Q9DCU0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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