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    hldE fused heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947548, updated on 6-Jun-2024

    Summary

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    Gene symbol
    hldE
    Gene description
    fused heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase
    Primary source
    ASAP:ABE-0010015
    Locus tag
    b3052
    See related
    ECOCYC:G7590
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK3042; gmhC; rfaE; waaE; yqiF
    Summary
    HldE is a bifunctional protein with an N-terminal ribokinase superfamily domain and a C-terminal cytidylyltransferase superfamily domain; the two domains are genetically separable . [More information is available at EcoCyc: G7590].
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    Genomic context

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    Sequence:
    NC_000913.3 (3195320..3196753, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene putative toxic peptide IbsD Neighboring gene ncRNA Neighboring gene toxic peptide IbsE Neighboring gene fused glutamine synthetase deadenylase/glutamine synthetase adenylyltransferase Neighboring gene inorganic triphosphatase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. HldE Is Important for Virulence Phenotypes in Enterotoxigenic Escherichia coli. Maigaard Hermansen GM, et al. Front Cell Infect Microbiol, 2018. PMID 30131942, Free PMC Article
    2. Functional analysis of the glycero-manno-heptose 7-phosphate kinase domain from the bifunctional HldE protein, which is involved in ADP-L-glycero-D-manno-heptose biosynthesis. McArthur F, et al. J Bacteriol, 2005 Aug. PMID 16030223, Free PMC Article
    3. The rfaC gene of Salmonella typhimurium. Cloning, sequencing, and enzymatic function in heptose transfer to lipopolysaccharide. Sirisena DM, et al. J Biol Chem, 1992 Sep 15. PMID 1527014
    4. Activation of the gab operon in an RpoS-dependent manner by mutations that truncate the inner core of lipopolysaccharide in Escherichia coli. Joloba ML, et al. J Bacteriol, 2004 Dec. PMID 15576807, Free PMC Article
    5. Biosynthesis pathway of ADP-L-glycero-beta-D-manno-heptose in Escherichia coli. Kneidinger B, et al. J Bacteriol, 2002 Jan. PMID 11751812, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables heptose 7-phosphate kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables heptose 7-phosphate kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables heptose 7-phosphate kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables heptose-1-phosphate adenylyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables heptose-1-phosphate adenylyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables heptose-1-phosphate adenylyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotidyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphotransferase activity, alcohol group as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in ADP-L-glycero-beta-D-manno-heptose biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within ADP-L-glycero-beta-D-manno-heptose biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in carbohydrate phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lipopolysaccharide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lipopolysaccharide core region biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within lipopolysaccharide core region biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    fused heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase
    NP_417524.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      3195320..3196753 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417524.1 fused heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417524.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A5C9AJI6
      Conserved Domains (1) summary
      PRK11316
      Location:1 → 473
      PRK11316; bifunctional D-glycero-beta-D-manno-heptose-7-phosphate kinase/D-glycero-beta-D-manno-heptose 1-phosphate adenylyltransferase HldE
    Nucleotide Protein
    Heading Accession and Version

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    Other Literature Sources
    Molecular Biology Databases
    Research Materials