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    Ptpn7 protein tyrosine phosphatase, non-receptor type 7 [ Mus musculus (house mouse) ]

    Gene ID: 320139, updated on 12-May-2024

    Summary

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    Official Symbol
    Ptpn7provided by MGI
    Official Full Name
    protein tyrosine phosphatase, non-receptor type 7provided by MGI
    Primary source
    MGI:MGI:2156893
    See related
    Ensembl:ENSMUSG00000031506 AllianceGenome:MGI:2156893
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    LPTP; HEPTP; BPTP-4; LC-PTP; C920001D21Rik
    Summary
    Predicted to enable protein tyrosine phosphatase activity. Acts upstream of or within protein dephosphorylation. Predicted to be located in cytoplasmic side of plasma membrane; cytosol; and mitotic spindle. Is expressed in liver and thymus primordium. Orthologous to human PTPN7 (protein tyrosine phosphatase non-receptor type 7). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in thymus adult (RPKM 47.9), spleen adult (RPKM 10.4) and 4 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ptpn7 in Genome Data Viewer
    Location:
    1 E4; 1 58.24 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (135059577..135073064)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (135131838..135145328)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E1231 Neighboring gene ubiquitin-conjugating enzyme E2T Neighboring gene leucine-rich repeat-containing G protein-coupled receptor 6 Neighboring gene STARR-seq mESC enhancer starr_02346 Neighboring gene STARR-seq mESC enhancer starr_02347 Neighboring gene protein tyrosine phosphatase receptor type V Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:137029652-137029867 Neighboring gene STARR-positive B cell enhancer ABC_E9480 Neighboring gene ADP-ribosylation factor-like 8A Neighboring gene G protein-coupled receptor 37-like 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Liver of MRL/lpr mice contain interleukin-4-producing lymphocytes and accessory cells that support the proliferation of Th2 helper T lymphocyte clones. Magilavy DB, et al. Eur J Immunol, 1992 Sep. PMID 1387611
    2. The protein tyrosine phosphatase PTPN7 is a negative regulator of ERK activation and thromboxane generation in platelets. Inamdar VV, et al. J Biol Chem, 2019 Aug 16. PMID 31266805, Free PMC Article
    3. Role of protein tyrosine phosphatase non-receptor type 7 in the regulation of TNF-α production in RAW 264.7 macrophages. Seo H, et al. PLoS One, 2013. PMID 24265715, Free PMC Article
    4. Hematopoietic protein tyrosine phosphatase suppresses extracellular stimulus-regulated kinase activation. Gronda M, et al. Mol Cell Biol, 2001 Oct. PMID 11564869, Free PMC Article
    5. Hematopoietic protein tyrosine phosphatase mediates beta2-adrenergic receptor-induced regulation of p38 mitogen-activated protein kinase in B lymphocytes. McAlees JW, et al. Mol Cell Biol, 2009 Feb. PMID 19047375, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PTPN7 regulates platelet functional responses downstream of GPCR agonists, but not GPVI agonists, through inhibition of ERK activation and thromboxane generation.
      Title: The protein tyrosine phosphatase PTPN7 is a negative regulator of ERK activation and thromboxane generation in platelets.
    2. PTPN7 as a negative regulator of TNF-alpha expression and the inflammatory response in macrophages
      Title: Role of protein tyrosine phosphatase non-receptor type 7 in the regulation of TNF-α production in RAW 264.7 macrophages.
    3. beta(2)AR stimulation on a B cell phosphorylates and inactivates HePTP in a Gs/cAMP/PKA-dependent manner to release bound p38 MAPK, making more available for phosphorylation and subsequent IgE regulation.
      Title: Hematopoietic protein tyrosine phosphatase mediates beta2-adrenergic receptor-induced regulation of p38 mitogen-activated protein kinase in B lymphocytes.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1)  1 citation

    Pathways from PubChem

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    General gene information

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    Homology

    Clone Names

    • MGC107411

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphoprotein phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein tyrosine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein tyrosine phosphatase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein dephosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein dephosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasmic side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in microtubule cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitotic spindle ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    tyrosine-protein phosphatase non-receptor type 7
    Names
    hematopoietic protein-tyrosine phosphatase
    NP_001343311.1
    NP_796055.1
    XP_006529759.1
    XP_006529761.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001356382.1 → NP_001343311.1  tyrosine-protein phosphatase non-receptor type 7

      Status: VALIDATED

      Source sequence(s)
      AC133097
      Consensus CDS
      CCDS15315.1
      UniProtKB/Swiss-Prot
      Q8BUM3
      UniProtKB/TrEMBL
      B7ZNE1
      Related
      ENSMUSP00000129474.2, ENSMUST00000167080.3
      Conserved Domains (1) summary
      cd14612
      Location:105 → 349
      PTPc-N7; catalytic domain of tyrosine-protein phosphatase non-receptor type 7

    2. NM_177081.4 → NP_796055.1  tyrosine-protein phosphatase non-receptor type 7

      See identical proteins and their annotated locations for NP_796055.1

      Status: VALIDATED

      Source sequence(s)
      AC133097
      Consensus CDS
      CCDS15315.1
      UniProtKB/Swiss-Prot
      Q8BUM3
      UniProtKB/TrEMBL
      B7ZNE1
      Related
      ENSMUSP00000045803.5, ENSMUST00000049449.11
      Conserved Domains (1) summary
      cd14612
      Location:105 → 349
      PTPc-N7; catalytic domain of tyrosine-protein phosphatase non-receptor type 7

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      135059577..135073064
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006529698.5 → XP_006529761.1  tyrosine-protein phosphatase non-receptor type 7 isoform X1

      See identical proteins and their annotated locations for XP_006529761.1

      UniProtKB/Swiss-Prot
      Q8BUM3
      UniProtKB/TrEMBL
      B7ZNE1
      Conserved Domains (1) summary
      cd14612
      Location:105 → 349
      PTPc-N7; catalytic domain of tyrosine-protein phosphatase non-receptor type 7

    2. XM_006529696.5 → XP_006529759.1  tyrosine-protein phosphatase non-receptor type 7 isoform X1

      See identical proteins and their annotated locations for XP_006529759.1

      UniProtKB/Swiss-Prot
      Q8BUM3
      UniProtKB/TrEMBL
      B7ZNE1
      Related
      ENSMUSP00000141133.2, ENSMUST00000187985.7
      Conserved Domains (1) summary
      cd14612
      Location:105 → 349
      PTPc-N7; catalytic domain of tyrosine-protein phosphatase non-receptor type 7
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BUM3.1 GenPept UniProtKB/Swiss-Prot:Q8BUM3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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