Neurog3 neurogenin 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Neurog3provided by MGI
Official Full Name: neurogenin 3provided by MGI
Primary source: MGI:MGI:893591
See related: Ensembl:ENSMUSG00000044312 AllianceGenome:MGI:893591
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: ngn3; Atoh5; Math4B; bHLHa7
Summary: Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin DNA binding activity. Involved in positive regulation of transcription, DNA-templated and transdifferentiation. Acts upstream of or within epithelial cell differentiation; positive regulation of transcription by RNA polymerase II; and regulation of dendrite morphogenesis. Located in nucleus. Is expressed in several structures, including early conceptus; eye; genitourinary system; gut; and nervous system. Human ortholog(s) of this gene implicated in congenital malabsorptive diarrhea 4; glucose intolerance; and type 2 diabetes mellitus. Orthologous to human NEUROG3 (neurogenin 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in duodenum adult (RPKM 2.0), large intestine adult (RPKM 1.3) and 5 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 B4; 10 32.35 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (61968869..61970542)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (62133090..62134763)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

USP7 controls NGN3 stability and pancreatic endocrine lineage development.
Title: USP7 controls NGN3 stability and pancreatic endocrine lineage development.
H3K4 Trimethylation Is Required for Postnatal Pancreatic Endocrine Cell Functional Maturation.
Title: H3K4 Trimethylation Is Required for Postnatal Pancreatic Endocrine Cell Functional Maturation.
Reduced Neurog3 Gene Dosage Shifts Enteroendocrine Progenitor Towards Goblet Cell Lineage in the Mouse Intestine.
Title: Reduced Neurog3 Gene Dosage Shifts Enteroendocrine Progenitor Towards Goblet Cell Lineage in the Mouse Intestine.
Ngn3-Positive Cells Arise from Pancreatic Duct Cells.
Title: Ngn3-Positive Cells Arise from Pancreatic Duct Cells.
Null mutations of NEUROG3 are associated with delayed-onset diabetes mellitus.
Title: Null mutations of NEUROG3 are associated with delayed-onset diabetes mellitus.
Silk Fibroin Promotes the Regeneration of Pancreatic beta-Cells in the C57BL/KsJ-Lepr(db/db) Mouse.
Title: Silk Fibroin Promotes the Regeneration of Pancreatic β-Cells in the C57BL/KsJ-Lepr(db/db) Mouse.
Estradiol-dependent axogenesis and Ngn3 expression are determined by XY sex chromosome complement in hypothalamic neurons.
Title: Estradiol-dependent axogenesis and Ngn3 expression are determined by XY sex chromosome complement in hypothalamic neurons.
SOX3 promotes generation of committed spermatogonia in postnatal mouse testes.
Title: SOX3 promotes generation of committed spermatogonia in postnatal mouse testes.
Here, we observed that treatment with Ad-FIGF was found to enhance MafA and Ngn3-induced reprogramming of BNL CL.2 cells to beta-like cells with the ability of secreting insulin.
Title: Effect of FIGF overexpression on liver cells transforming to insulin-producing cells.
Neurogenin3 phosphorylation controls reprogramming efficiency of pancreatic ductal organoids into endocrine cells.
Title: Neurogenin3 phosphorylation controls reprogramming efficiency of pancreatic ductal organoids into endocrine cells.

Submit: New GeneRIF Correction See all GeneRIFs (96)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (11) 1 citation
Endonuclease-mediated (2)

General gene information

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Markers

PMC85623P2 (e-PCR)
- UniSTS:273479

PMC85812P4 (e-PCR)
- UniSTS:273497

UniSTS:462689 (e-PCR)
- UniSTS:462689

Neurog3 (e-PCR), detects polymorphism
- UniSTS:462689

Neurog3 (e-PCR), detects polymorphism
- UniSTS:525715

NoName (e-PCR)
- UniSTS:489116

Neurog3 (e-PCR), detects polymorphism
- UniSTS:496541

Neurog3 (e-PCR), detects polymorphism
- UniSTS:516528

PMC26482P1 (e-PCR)
- UniSTS:272337

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription activator activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables E-box binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables chromatin DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables double-stranded DNA binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in axon development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within epithelial cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in forebrain development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within multicellular organism development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within nervous system development	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of neuron differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of dendrite morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in sensory organ development	IBA Inferred from Biological aspect of Ancestor more info
involved_in transdifferentiation	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cytosol	TAS Traceable Author Statement more info
located_in intracellular anatomical structure	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: neurogenin-3

Names: Neurogenin 3 (Atonal protein homolog 5) (Helix-loop-helix protein mATH-4B) (MATH4B); atonal homolog 5; helix-loop-helix protein mATH-4B; protein atonal homolog 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_009719.6 → NP_033849.3 neurogenin-3

See identical proteins and their annotated locations for NP_033849.3

Status: VALIDATED

Source sequence(s)

AC127417

Consensus CDS

CCDS23887.1

UniProtKB/Swiss-Prot

P70661

UniProtKB/TrEMBL

Q548G3, Q9D8I0

Related

ENSMUSP00000054054.2, ENSMUST00000050103.2

Conserved Domains (1) summary

cd00083
Location:81 → 140

HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...