CIAPIN1 cytokine induced apoptosis inhibitor 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: CIAPIN1provided by HGNC
Official Full Name: cytokine induced apoptosis inhibitor 1provided by HGNC
Primary source: HGNC:HGNC:28050
See related: Ensembl:ENSG00000005194 MIM:608943; AllianceGenome:HGNC:28050
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: DRE2; CIAE2; PRO0915; Anamorsin
Summary: CIAPIN1 is a cytokine-induced inhibitor of apoptosis with no relation to apoptosis regulatory molecules of the BCL2 (MIM 151430) or CASP (see MIM 147678) families. Expression of CIAPIN1 is dependent on growth factor stimulation (Shibayama et al., 2004 [PubMed 14970183]).[supplied by OMIM, Mar 2008]
Expression: Broad expression in testis (RPKM 38.4), placenta (RPKM 14.2) and 24 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 16q21

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	16	NC_000016.10 (57428187..57447385, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	16	NC_060940.1 (63223362..63242561, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	16	NC_000016.9 (57462099..57481297, complement)

Chromosome 16 - NC_000016.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

High CIAPIN1 expression is correlated with Non-small Cell Lung Cancer.
Title: MiRNA-195-5p Functions as a Tumor Suppressor and a Predictive of Poor Prognosis in Non-small Cell Lung Cancer by Directly Targeting CIAPIN1.
NHE1 (Na+/H+ exchanger 1) expression and ERK1/2 phosphorylation decreased along with CIAPIN1 upregulation.
Title: CIAPIN1 Targeted NHE1 and ERK1/2 to Suppress NSCLC Cells' Metastasis and Predicted Good Prognosis in NSCLC Patients Receiving Pulmonectomy.
The [2Fe-2S] clusters of mitoNEET are reduced via the formation of a transient complex that brings the [2Fe-2S] clusters of mitoNEET close to the redox-active [2Fe-2S] cluster of anamorsin.
Title: Anamorsin/Ndor1 Complex Reduces [2Fe-2S]-MitoNEET via a Transient Protein-Protein Interaction.
the effects of CIAPIN-1 in chondrocytes, focusing on extracellular signal-regulated kinase (ERK)-1/2 and p38 kinase signaling
Title: Cytokine-induced apoptosis inhibitor-1 causes dedifferentiation of rabbit articular chondrocytes via the ERK-1/2 and p38 kinase pathways.
results of the present study suggest that downregulation of the CIAPIN1 gene in multiple myeloma cells may be associated with the development of this disease.
Title: Cytokine-induced apoptosis inhibitor 1 inhibits the growth and proliferation of multiple myeloma.
CIAPIN1 and ABCA13 may be novel markers of poor outcome in pre-chemotherapy serous carcinoma effusions.
Title: CIAPIN1 and ABCA13 are markers of poor survival in metastatic ovarian serous carcinoma.
CIAPIN1 over-expression decreases NHE1 expression and ERK1/2 phosphorylation.
Title: CIAPIN1 targets Na⁺/H⁺ exchanger 1 to mediate MDA-MB-231 cells' metastasis through regulation of MMPs via ERK1/2 signaling pathway.
lentivirus-vector-mediated RNAi targeting of CIAPIN1 is a potential approach to reverse MDR of breast cancer and CIAPIN1 may participate in MDR of breast cancer by regulating P-glycoprotein and P53 expression.
Title: CIAPIN1 gene silencing enhances chemosensitivity in a drug-resistant animal model in vivo.
the 25-kDa cleaved fragment of anamorsin was detected in post-mortem brains of Alzheimer and Parkinson disease patients
Title: Anamorsin, a novel caspase-3 substrate in neurodegeneration.
The N-terminal methyltransferase-like domain of anamorsin probably functions as a structural scaffold to inhibit methyl transfers.
Title: Crystal structure of the N-terminal methyltransferase-like domain of anamorsin.

Submit: New GeneRIF Correction See all GeneRIFs (29)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

ha3079 (e-PCR)
- UniSTS:515639

RH11736 (e-PCR)
- UniSTS:84285

A007G23 (e-PCR)
- UniSTS:7263

SHGC-61194 (e-PCR)
- UniSTS:21097

IB525 (e-PCR)
- UniSTS:25848

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables 2 iron, 2 sulfur cluster binding	IDA Inferred from Direct Assay more info	PubMed
enables 4 iron, 4 sulfur cluster binding	IEA Inferred from Electronic Annotation more info
enables electron transfer activity	IEA Inferred from Electronic Annotation more info
enables iron ion binding	EXP Inferred from Experiment more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in hemopoiesis	IEA Inferred from Electronic Annotation more info
involved_in iron-sulfur cluster assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of apoptotic process	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in mitochondrial intermembrane space	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	IDA Inferred from Direct Assay more info
located_in nucleolus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	IDA Inferred from Direct Assay more info

General protein information

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Preferred Names: anamorsin

Names: fe-S cluster assembly protein DRE2 homolog; predicted protein of HQ0915

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001308347.2 → NP_001295276.1 anamorsin isoform 2

See identical proteins and their annotated locations for NP_001295276.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 2.

Source sequence(s)

AC009052, AL136613

Consensus CDS

CCDS76876.1

UniProtKB/Swiss-Prot

Q6FI81

Related

ENSP00000456114.1, ENST00000567518.5

Conserved Domains (1) summary

pfam05093
Location:227 → 291

CIAPIN1; Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis
NM_001308358.2 → NP_001295287.1 anamorsin isoform 3

Status: VALIDATED

Description

Transcript Variant: This variant (3) lacks an in-frame exon compared to variant 1. The encoded isoform (3)

Source sequence(s)

AF248964, BC067303, BG746807, BJ991015

Consensus CDS

CCDS76877.1

UniProtKB/TrEMBL

H3BPG7, H3BT65

Related

ENSP00000457042.1, ENST00000569370.5

Conserved Domains (1) summary

cl17173
Location:3 → 95

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
NM_020313.4 → NP_064709.2 anamorsin isoform 1

See identical proteins and their annotated locations for NP_064709.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AF248964, BC024196, BC067303

Consensus CDS

CCDS10781.2

UniProtKB/Swiss-Prot

A8K8B6, O75206, O75207, Q6FI81, Q9H0W1, Q9P1L7

Related

ENSP00000377914.4, ENST00000394391.9

Conserved Domains (2) summary

pfam05093
Location:240 → 304

CIAPIN1; Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis

cl17173
Location:3 → 95

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...