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    GLP2R glucagon like peptide 2 receptor [ Homo sapiens (human) ]

    Gene ID: 9340, updated on 3-Apr-2024

    Summary

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    Official Symbol
    GLP2Rprovided by HGNC
    Official Full Name
    glucagon like peptide 2 receptorprovided by HGNC
    Primary source
    HGNC:HGNC:4325
    See related
    Ensembl:ENSG00000065325 MIM:603659; AllianceGenome:HGNC:4325
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    This gene encodes a G protein-coupled receptor that is closely related to the glucagon receptor and binds to glucagon-like peptide-2 (GLP2). Signalling through GLP2 stimulates intestinal growth and increases villus height in the small intestine, concomitant with increased crypt cell proliferation and decreased enterocyte apoptosis. [provided by RefSeq, Dec 2014]
    Expression
    Biased expression in gall bladder (RPKM 4.7), small intestine (RPKM 2.6) and 8 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    17p13.1
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (9825924..9892099)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (9733669..9799834)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (9729241..9795416)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr17:9680825-9681382 Neighboring gene DHRS7C intron CAGE-defined high expression enhancer Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_47652 Neighboring gene dehydrogenase/reductase 7C Neighboring gene uncharacterized LOC124903925 Neighboring gene GSG1 like 2 Neighboring gene nucleophosmin 1 pseudogene 45 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:9802365-9802866 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_47676 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:9828374-9829300 Neighboring gene recoverin Neighboring gene growth arrest specific 7 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:9862137-9862330 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:9884467-9884968 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:9929360-9929865 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:9929866-9930370 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:9937053-9937552 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:9936551-9937052 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11728 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_47688 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11729 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:9964299-9964800 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:9971697-9972196 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:10010547-10011088 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8199 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:10021115-10021644 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:10020585-10021114 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:10022175-10022702 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:10022877-10023835 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:10030567-10031284 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11730 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:10074140-10074966 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:10074967-10075792 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:10076620-10077445 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr17:10083873-10084415

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Expression, purification and molecular dynamics simulation of extracellular domain of glucagon-like peptide-2 receptor linked to teduglutide. Jamshidi Kandjani O, et al. Int J Biol Macromol, 2021 Aug 1. PMID 34174312
    2. A unique hormonal recognition feature of the human glucagon-like peptide-2 receptor. Sun W, et al. Cell Res, 2020 Dec. PMID 33239759, Free PMC Article
    3. Increased GLP2R expression in gastric chief cells of patients with severe obesity regardless of diabetes status. Li F, et al. Int J Obes (Lond), 2017 Aug. PMID 28337026
    4. The CNS glucagon-like peptide-2 receptor in the control of energy balance and glucose homeostasis. Guan X. Am J Physiol Regul Integr Comp Physiol, 2014 Sep 15. PMID 24990862, Free PMC Article
    5. GLP-2 receptors in human disease: high expression in gastrointestinal stromal tumors and Crohn's disease. Körner M, et al. Mol Cell Endocrinol, 2012 Nov 25. PMID 22951144

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A unique hormonal recognition feature of the human glucagon-like peptide-2 receptor.
      Title: A unique hormonal recognition feature of the human glucagon-like peptide-2 receptor.
    2. Expression, purification and molecular dynamics simulation of extracellular domain of glucagon-like peptide-2 receptor linked to teduglutide.
      Title: Expression, purification and molecular dynamics simulation of extracellular domain of glucagon-like peptide-2 receptor linked to teduglutide.
    3. Epicardial, pericardial fat and glucagon-like peptide-1 and -2 receptors expression in stable patients with multivessel coronary artery disease: an association with the renin-angiotensin-aldosterone system.
      Title: Epicardial, pericardial fat and glucagon-like peptide-1 and -2 receptors expression in stable patients with multivessel coronary artery disease: an association with the renin-angiotensin-aldosterone system.
    4. Loss of Glp2r signaling activates hepatic stellate cells and exacerbates diet-induced steatohepatitis in mice.
      Title: Loss of Glp2r signaling activates hepatic stellate cells and exacerbates diet-induced steatohepatitis in mice.
    5. This is the first evidence of abnormal gene expression of GLP-1R and GLP-2R in postmortem brain of individuals with Mood Disorder.
      Title: The effect of body mass index on glucagon-like peptide receptor gene expression in the post mortem brain from individuals with mood and psychotic disorders.
    6. GLP2R expression was significantly increased in gastric chief cells in OB and OWD patients. PKCzeta expression was also significantly increased. This is the first evidence of increased GLP2R expression in chief cells of patients with severe obesity regardless of diabetes status.
      Title: Increased GLP2R expression in gastric chief cells of patients with severe obesity regardless of diabetes status.
    7. GLP-2 augmented BRIN BD11 beta-cell proliferation, but was less efficacious in 1.1B4 cells. These data highlight the involvement of GLP-2 receptor signalling in the adaptations to pancreatic islet cell stress.
      Title: Differential expression of glucagon-like peptide-2 (GLP-2) is involved in pancreatic islet cell adaptations to stress and beta-cell survival.
    8. This is the first time that human Epicardial adipose tissue is found to express both GLP-1R and GLP-2R genes.
      Title: Human Epicardial Fat Expresses Glucagon-Like Peptide 1 and 2 Receptors Genes.
    9. Report gastrointestinal GLP-2 receptor and limited utility of GLP-2 in the management of inflammatory intestinal disorders.
      Title: Glugacon-like peptide-2: broad receptor expression, limited therapeutic effect on intestinal inflammation and novel role in liver regeneration.
    10. GLP-2 receptors are highly expressed in gastrointestinal stromal tumors and Crohn's disease.
      Title: GLP-2 receptors in human disease: high expression in gastrointestinal stromal tumors and Crohn's disease.
    Submit: New GeneRIF Correction See all GeneRIFs (21)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables glucagon receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables peptide hormone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell surface receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to glucagon stimulus IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of cell population proliferation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane TAS
    Traceable Author Statement
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    glucagon-like peptide 2 receptor
    Names
    GLP-2 receptor
    epididymis secretory sperm binding protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_004246.3 → NP_004237.1  glucagon-like peptide 2 receptor

      See identical proteins and their annotated locations for NP_004237.1

      Status: REVIEWED

      Source sequence(s)
      AC026591, AK314269, BC096262
      Consensus CDS
      CCDS11150.1
      UniProtKB/Swiss-Prot
      O95838, Q4VAT3
      UniProtKB/TrEMBL
      A0A384MTS7, B2RAN4
      Related
      ENSP00000262441.5, ENST00000262441.10
      Conserved Domains (2) summary
      pfam02793
      Location:93 → 162
      HRM; Hormone receptor domain
      cd15266
      Location:175 → 453
      7tmB1_GLP2R; glucagon-like peptide-2 receptor, member of the class B family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      9825924..9892099
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011524077.4 → XP_011522379.1  glucagon-like peptide 2 receptor isoform X1

      UniProtKB/TrEMBL
      B2RAN4
      Conserved Domains (2) summary
      pfam00002
      Location:200 → 457
      7tm_2; 7 transmembrane receptor (Secretin family)
      pfam02793
      Location:93 → 187
      HRM; Hormone receptor domain

    2. XM_017025339.2 → XP_016880828.1  glucagon-like peptide 2 receptor isoform X2

      UniProtKB/TrEMBL
      B2RAN4

    3. XM_017025340.2 → XP_016880829.1  glucagon-like peptide 2 receptor isoform X3

      UniProtKB/TrEMBL
      B2RAN4

    4. XM_017025341.2 → XP_016880830.1  glucagon-like peptide 2 receptor isoform X4

      UniProtKB/TrEMBL
      I3L0P5
      Related
      ENSP00000458242.1, ENST00000574745.5

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      9733669..9799834
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054317814.1 → XP_054173789.1  glucagon-like peptide 2 receptor isoform X1

    2. XM_054317815.1 → XP_054173790.1  glucagon-like peptide 2 receptor isoform X2

    3. XM_054317816.1 → XP_054173791.1  glucagon-like peptide 2 receptor isoform X3

    4. XM_054317817.1 → XP_054173792.1  glucagon-like peptide 2 receptor isoform X4

    5. XM_054317818.1 → XP_054173793.1  glucagon-like peptide 2 receptor isoform X5

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O95838.1 GenPept UniProtKB/Swiss-Prot:O95838

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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