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    MTR 5-methyltetrahydrofolate-homocysteine methyltransferase [ Bos taurus (cattle) ]

    Gene ID: 280869, updated on 6-Jun-2024

    Summary

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    Official Symbol
    MTRprovided by VGNC
    Official Full Name
    5-methyltetrahydrofolate-homocysteine methyltransferaseprovided by VGNC
    Primary source
    VGNC:VGNC:31749
    See related
    BGD:BT23506; Ensembl:ENSBTAG00000012251
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See MTR in Genome Data Viewer
    Location:
    chromosome: 28
    Exon count:
    34
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 28 NC_037355.1 (9420582..9552895)

    Chromosome 28 - NC_037355.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101908221 Neighboring gene U6 spliceosomal RNA Neighboring gene actinin alpha 2 Neighboring gene transfer RNA glutamic acid (anticodon UUC) Neighboring gene uncharacterized LOC132344162 Neighboring gene ryanodine receptor 2 Neighboring gene microRNA mir-2285ag

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037355.1 Chromosome 28 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Effects of dietary supplements of folic acid and vitamin B12 on metabolism of dairy cows in early lactation. Graulet B, et al. J Dairy Sci, 2007 Jul. PMID 17582128
    2. Hepatic Activity and Transcription of Betaine-Homocysteine Methyltransferase, Methionine Synthase, and Cystathionine Synthase in Periparturient Dairy Cows Are Altered to Different Extents by Supply of Methionine and Choline. Zhou Z, et al. J Nutr, 2017 Jan. PMID 27881594

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These findings indicate that greater synthesis of phosphatidylcholine and antioxidants contribute to the better performance and immuno-metabolic status in methionine-supplemented cows.
      Title: Hepatic Activity and Transcription of Betaine-Homocysteine Methyltransferase, Methionine Synthase, and Cystathionine Synthase in Periparturient Dairy Cows Are Altered to Different Extents by Supply of Methionine and Choline.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables cobalamin binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables methionine synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in methionine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in pteridine-containing compound metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    methionine synthase
    Names
    MS
    cobalamin-dependent methionine synthase
    vitamin-B12 dependent methionine synthase
    NP_001025469.1
    XP_010818713.1
    XP_024842271.1
    XP_059738391.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001030298.1 → NP_001025469.1  methionine synthase

      See identical proteins and their annotated locations for NP_001025469.1

      Status: PROVISIONAL

      Source sequence(s)
      DQ084519
      UniProtKB/Swiss-Prot
      Q4JIJ3
      UniProtKB/TrEMBL
      F1N0S3
      Related
      ENSBTAP00000067894.2, ENSBTAT00000082214.2
      Conserved Domains (5) summary
      COG0646
      Location:21 → 340
      MetH1; Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]
      PRK09490
      Location:14 → 1261
      metH; B12-dependent methionine synthase; Provisional
      cd00740
      Location:371 → 627
      MeTr; MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent ...
      cd02069
      Location:671 → 897
      methionine_synthase_B12_BD; B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy).
      pfam02965
      Location:965 → 1246
      Met_synt_B12; Vitamin B12 dependent methionine synthase, activation domain

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037355.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      9420582..9552895
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_010820411.4 → XP_010818713.1  methionine synthase isoform X1

      UniProtKB/TrEMBL
      A0A3Q1MEQ8, F1N0S3
      Related
      ENSBTAP00000069537.2, ENSBTAT00000080747.2
      Conserved Domains (5) summary
      COG0646
      Location:20 → 339
      MetH1; Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]
      PRK09490
      Location:13 → 1260
      metH; B12-dependent methionine synthase; Provisional
      cd00740
      Location:370 → 626
      MeTr; MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent ...
      cd02069
      Location:670 → 896
      methionine_synthase_B12_BD; B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy).
      pfam02965
      Location:964 → 1245
      Met_synt_B12; Vitamin B12 dependent methionine synthase, activation domain

    2. XM_024986503.2 → XP_024842271.1  methionine synthase isoform X2

      UniProtKB/TrEMBL
      F1N0S3
      Conserved Domains (1) summary
      cl22882
      Location:1 → 995
      S-methyl_trans; Homocysteine S-methyltransferase

    3. XM_059882408.1 → XP_059738391.1  methionine synthase isoform X3

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q4JIJ3.1 GenPept UniProtKB/Swiss-Prot:Q4JIJ3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials